A Convenient Synthesis of Novel Isoxazolidine and Isoxazole Isoquinolinones Fused Hybrids [PDF]
Molecules, 2023 Isoxazolidine, isoxazole, and isoquinolinone rings are present in the structure of several natural products and/or pharmaceutically interesting compounds.
Konstantinos A. Ouzounthanasis +2 more
doaj +2 more sources
Phosphorylated Nitrones-Synthesis and Applications. [PDF]
MoleculesPhosphorylated nitrones belong to an important class of compounds with several applications, such as their therapeutic potency to reduce oxidative stress or as spin-trapping agents. This review covers available synthetic methods for the preparation of both non-cyclic and cyclic phosphorylated nitrones, including the possibilities of the modification of
Rozpara I +3 more
europepmc +5 more sources
Preparation of spirocyclic oxindoles by cyclisation of an oxime to a nitrone and dipolar cycloaddition [PDF]
Beilstein Journal of Organic ChemistryOxindoles are an important class of compounds with significant biological activities. Spirocyclic derivatives are present in a variety of natural products.
Beth L. Ritchie +2 more
doaj +2 more sources
Crystal and Molecular Structures of N-benzyl-C-(2-pyridyl) nitrone and its ZnBr2 Complex. A Study of Their Reactivity [PDF]
Molecules, 2001 The ZnBr2 complex of the title compound has been studied by both structural and theoretical methods. Similar reactivities have been observed for the nitrone alone and the complex in 1,3-dipolar cycloadditions and nucleophilic additions.
Tomas Tejero +5 more
doaj +2 more sources
Dialkylzinc-Assisted Alkynylation of Nitrones [PDF]
Organic Letters, 2002 AbstractFor Abstract see ChemInform Abstract in Full Text.
Chavant, Pierre Yves +4 more
openaire +6 more sources
Catalytic enantioselective nitrone cycloadditions enabling collective syntheses of indole alkaloids [PDF]
Nature CommunicationsTetrahydro-β-carboline skeletons are prominent and ubiquitous in an extraordinary range of indole alkaloid natural products and pharmaceutical compounds. Powerful synthetic approaches for stereoselective synthesis of tetrahydro-β-carboline skeletons have
Xiaochen Tian +9 more
doaj +2 more sources
Electron paramagnetic resonance spectroscopy for analysis of free radicals in zebrafish. [PDF]
PLoS ONEElectron paramagnetic resonance (EPR) is an excellent choice for detecting free radicals in biological samples. Biologically relevant radicals are extremely short-lived and cannot be detected directly, emphasizing the need for an appropriate compound to ...
Mitra Sabetghadam Moghadam +4 more
doaj +2 more sources
Reactions of a-Ketosulfenes with Nitrones
HETEROCYCLES, 1976 AbstractDie Sulfene (I), (II) und (III) ergeben mit den Nitronen (IV) unter Umlagerung siebengliedrige, cyclische Azasultone.
Michihiko Noguchi, Otohiko Tsuge
openaire +3 more sources
A practical synthesis of nitrone-derived C5a-functionalized isofagomines as protein stabilizers to treat Gaucher disease [PDF]
Communications ChemistryIsofagomine (IFG) and its analogues possess promising glycosidase inhibitory activities. However, a flexible synthetic strategy toward both C5a-functionalized IFGs remains to be explored.
Huang-Yi Li +9 more
doaj +2 more sources
Nitrones as therapeutics [PDF]
Free Radical Biology and Medicine, 2008 Nitrones have the general chemical formula X-CH=NO-Y. They were first used to trap free radicals in chemical systems and then subsequently in biochemical systems. More recently several nitrones, including alpha-phenyl-tert-butylnitrone (PBN), have been shown to have potent biological activity in many experimental animal models.
Sabrina Doblas +6 more
openaire +3 more sources