Nitrones: Comprehensive Review on Synthesis and Applications [PDF]
MoleculesNitrones are a significant class of compounds highly useful in organic synthesis; in particular, they are key intermediates for the synthesis of new biologically active nitrogen compounds.
Ricardo A. L. S. Santos +2 more
doaj +2 more sources
Preparation of spirocyclic oxindoles by cyclisation of an oxime to a nitrone and dipolar cycloaddition [PDF]
Beilstein Journal of Organic ChemistryOxindoles are an important class of compounds with significant biological activities. Spirocyclic derivatives are present in a variety of natural products.
Beth L. Ritchie +2 more
doaj +2 more sources
Electrochemistry and Antioxidant Activities of Substituted Furanyl Nitrone: The Role of the Nitro Group [PDF]
ChemElectroChemThis work compares electrochemical and antioxidant data for synthetic furfural‐derived nitrone (LQB‐109), the novel N‐methyl‐nitroaryl‐furanyl‐nitrone (LQB‐569), and the parent aldehyde (5NBFAL). Cyclic voltammograms (CVs) are obtained on a glassy carbon
Danyelle Cândido Santos +9 more
doaj +2 more sources
Catalytic enantioselective nitrone cycloadditions enabling collective syntheses of indole alkaloids [PDF]
Nature CommunicationsTetrahydro-β-carboline skeletons are prominent and ubiquitous in an extraordinary range of indole alkaloid natural products and pharmaceutical compounds. Powerful synthetic approaches for stereoselective synthesis of tetrahydro-β-carboline skeletons have
Xiaochen Tian +9 more
doaj +2 more sources
Electron paramagnetic resonance spectroscopy for analysis of free radicals in zebrafish. [PDF]
PLoS ONEElectron paramagnetic resonance (EPR) is an excellent choice for detecting free radicals in biological samples. Biologically relevant radicals are extremely short-lived and cannot be detected directly, emphasizing the need for an appropriate compound to ...
Mitra Sabetghadam Moghadam +4 more
doaj +2 more sources
A practical synthesis of nitrone-derived C5a-functionalized isofagomines as protein stabilizers to treat Gaucher disease [PDF]
Communications ChemistryIsofagomine (IFG) and its analogues possess promising glycosidase inhibitory activities. However, a flexible synthetic strategy toward both C5a-functionalized IFGs remains to be explored.
Huang-Yi Li +9 more
doaj +2 more sources
Kinetics and mechanism of the oxidation of some substituted aldonitrones by quinolinium chlorochromate in aqueous DMF medium in the absence and presence of oxalic acid [PDF]
Journal of the Serbian Chemical Society, 2009 The kinetics of the oxidation of aldonitrones (nitrone) by quinolinium chlorochromate (QCC) was determined in 50 % DMF-water in the absence and presence of oxalic acid in order to study the effect of oxalic acid.
Rajarajan Govindasamy +4 more
doaj +3 more sources
Iron-Catalyzed Alkylation-Reduction of <i>N</i>-Methyl Nitrones via LMCT Activation. [PDF]
Org LettGonçalves RO +6 more
europepmc +2 more sources
Antioxidants, 2021 Synthetic nitrone spin-traps are being explored as therapeutic agents for the treatment of a wide range of oxidative stress-related pathologies, including but not limited to stroke, cancer, cardiovascular, and neurodegenerative diseases. In this context,
Stefania Marano +8 more
doaj +1 more source
A Convenient Synthesis of Novel Isoxazolidine and Isoxazole Isoquinolinones Fused Hybrids
Molecules, 2023 Isoxazolidine, isoxazole, and isoquinolinone rings are present in the structure of several natural products and/or pharmaceutically interesting compounds.
Konstantinos A. Ouzounthanasis +2 more
doaj +1 more source