Results 41 to 50 of about 7,972 (156)

Simultaneous Grafting of 3,4,5‐Trihydroxypiperidine Iminosugars Onto Multivalent Scaffolds via Double Reductive Amination Provides New GCase Inhibitors

Chemistry – A European Journal, Volume 32, Issue 2, 9 January 2026.
A small set of low‐valency multivalent 3,4,5‐trihydroxypiperidines was prepared through double reductive amination (DRA) of a sugar‐derived dialdehyde. Among them, trivalent derivative 37 emerged as a potent β‐glucocerebrosidase (GCase) inhibitor displaying an unexpected mixed‐type kinetic profile. The integration of kinetic analysis, NMR, docking, and
Maria Giulia Davighi, Francesca Clemente, Alessio Morano, Francesca Mangiavacchi, Francesca Cardona, Andrea Goti, Paolo Paoli, Amelia Morrone, Ferran Nieto‐Fabregat, Roberta Marchetti, Camilla Matassini   +10 more
wiley   +1 more source

Skeletal Editing of Alkenes with Nitroarenes via Photoinduced Rearrangement of N─O═C Dipoles Forms Lactams and Amides

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Skeletal editing of alkenes via the cascade cleavage of C(sp2)═C(sp2) and C(sp3)─C(sp3) bonds, enabling the insertion of the nitrogen atom and thereby the synthesis of lactam and amide derivatives using nitroarenes as nitrogen atom insertion reagents under light irradiation.
Hongyun Qin, Zemin Wang, Cong Shi, Jiashu Chen, Chao Liu, Xiangqian Li, Ruihua Liu, Dayong Shi   +7 more
wiley   +1 more source

SYNTHESES AND ANTIFUNGAL ACTIVITY OF 3-ARYLMETHYL-5-ARYLOXY METHYL-2- METHY LISOXAZOLIDINES [PDF]

Journal of Sciences, Islamic Republic of Iran, 1998
Reaction of sodium salt of allyl alcohol with 2-chloro-5-phenyl- l,3,4-thiadiazole gave 2-allyloxy-5-phenyl-1,3,4-thiadiazole 2. Compounds 4a and 4b could be obtained through the reaction of nitrone 3 with 2.
doaj  

From Molecule to Meaning: Click and Bioorthogonal Chemical Reporters for Plant Systems, Biological Imaging, and Artistic Expression

ChemBioChem, Volume 27, Issue 1, January 2026.
At the intersection of chemical biology, plant imaging, and contemporary art, this review introduces the concept of chembioart. By tracing how chemical reporters illuminate plant biomolecules in vivo, their role not only in advancing scientific understanding but also in inspiring transdisciplinary collaborations and visual expression is highlighted ...
Marie Hinnebo, Clémence Simon, Adèle Tilouine, Corentin Spriet, Christophe Biot   +4 more
wiley   +1 more source

Bismuth Compounds React With a Nitrone: Lewis Pair Formation and Quantification of Radical Trapping

Helvetica Chimica Acta, Volume 109, Issue 1, January 2026.
The spin trap Simple Lewis adducts of the spin trap α‐phenyl‐N‐tertbutyl‐nitrone (PBN) are reported for the first time, using the dimethyl bismuth cation [BiMe2(SbF6)] as a Lewis‐acidic bonding partner. The ability of [BiMe2(SbF6)] and a range of neutral organobismuth compounds to transfer organic radicals to PBN is demonstrated qualitatively and ...
Andreas Stoy, Johannes Schwarzmann, Felix Geist, Ahmed Fetoh, Malte Jürgensen, Jordi Poater, Istemi Kuzu, Crispin Lichtenberg   +7 more
wiley   +1 more source

Improvement of pharmacokinetics behavior of apocynin by nitrone derivatization: comparative pharmacokinetics of nitrone-apocynin and its parent apocynin in rats. [PDF]

PLoS ONE, 2013
Apocynin, a potent inhibitor of NADPH-oxidase, was widely studied for activities in diseases such as inflammation-mediated disorders, asthma and cardiovascular diseases.
Kaiyu Wang, Linlin Li, Yan Song, Xiaocui Ye, Shaolian Fu, Jie Jiang, Sha Li   +6 more
doaj   +1 more source

Cooperative Photocatalysis of 9,10‐Phenanthrenequinone and Sn(OTf)2 for Direct Mannich Reaction of Ethers via Hydrogen Atom Transfer Pathway

Advanced Synthesis &Catalysis, Volume 367, Issue 23, December 11, 2025.
A dual photocatalytic system of o‐PQ and Sn(OTf)2 enables visible light‐induced Mannich‐type addition of ethers to nitrones via Csp³–H activation. This oxidant‐free method offers broad scope and good yields. Mechanistic studies suggest that a photoexcited o‐PQ–Sn(II) complex mediates hydrogen atom transfer to form α‐oxy radicals for nitrone addition. A
Pradip Ramdas Thorve, Hun Young Kim, Kyungsoo Oh   +2 more
wiley   +1 more source

Crystal and Molecular Structures of N-benzyl-C-(2-pyridyl) nitrone and its ZnBr2 Complex. A Study of Their Reactivity

Molecules, 2001
The ZnBr2 complex of the title compound has been studied by both structural and theoretical methods. Similar reactivities have been observed for the nitrone alone and the complex in 1,3-dipolar cycloadditions and nucleophilic additions.
Tomas Tejero, Ana Moreno, Mariano Laguna, Elena Cerrada, Sonia Anoro, Pedro Merino   +5 more
doaj   +1 more source

Engineering exosomes for Alzheimer's disease: Multi‐target therapeutic strategies from pathogenesis to clinical translation

Clinical and Translational Medicine, Volume 15, Issue 12, December 2025.
Exosomes, modified through multidimensional approaches including physical, chemical and genetic means, and equipped with brain‐targeted peptides and therapeutic agents, are capable of crossing the blood‒brain barrier for precise delivery. They can simultaneously remove amyloid‐beta plaques and neurofibrillary tangle, inhibit neuroinflammation, and pave
Yuehan Zhang, Zhenyang Li, Haien Guan, Zhenhua Qiu, Chunlin Zou   +4 more
wiley   +1 more source

Recent Advances in Ene Reactions with Carbon Enophiles

Advanced Synthesis &Catalysis, Volume 367, Issue 22, November 28, 2025.
Recent advances in the classical intra‐ and intermolecular ene nexus with carbon enophiles (alkenes, alkynes, arynes, and allenes) show a considerable increase in structural complexity and an enormous potential for functional applications in polymer science.
Thomas J. J. Müller
wiley   +1 more source