Results 51 to 60 of about 7,868 (205)

Reaction of Nitrones with Phosphinylallenes: DFT Mechanistic Investigations

European Journal of Organic Chemistry, Volume 28, Issue 28, July 29, 2025.
The mechanism of the reaction between phosphinylallenes and nitrones is investigated by DFT calculations to elucidate the overall pathway and the stereochemical outcome. The initial (3+2) cycloaddition delivers an unstable isoxazolidine ylidene intermediate, spontaneously rearranging to the 4‐phosphinylpyrrolidin‐3‐one via a radical pathway. This study
Rayhane Hammami, Pascale Maldivi, Sébastien Carret, Soufiane Touil, Jean‐François Poisson, Benjamin Darses   +5 more
wiley   +1 more source

Synthesis of Pyrrolidin‐3‐Ones and Spiropyrrolidinones by 1,3‐Dipolar Cycloadditions of Nitrones with Allenylphosphonates

European Journal of Organic Chemistry, Volume 28, Issue 27, July 25, 2025.
This work introduces an efficient and gram‐scale microwave‐assisted (3+2) cycloaddition of nitrones with fluorinated allenylphosphonates, yielding diverse 4‐phosphinyl‐pyrrolidin‐3‐ones with exclusive 4,5‐trans diastereoselectivity in moderate to good yields.
Rayhane Hammami, Lucas Mele, Soufiane Touil, David Virieux, Jean‐François Poisson, Tahar Ayad, Benjamin Darses   +6 more
wiley   +1 more source

Improvement of pharmacokinetics behavior of apocynin by nitrone derivatization: comparative pharmacokinetics of nitrone-apocynin and its parent apocynin in rats. [PDF]

PLoS ONE, 2013
Apocynin, a potent inhibitor of NADPH-oxidase, was widely studied for activities in diseases such as inflammation-mediated disorders, asthma and cardiovascular diseases.
Kaiyu Wang, Linlin Li, Yan Song, Xiaocui Ye, Shaolian Fu, Jie Jiang, Sha Li   +6 more
doaj   +1 more source

Polymergebundene Nitrone

, 2002
In den letzten Jahren ist die Nachfrage nach Datenspeichern und ihrer Speicherkapazität immer größer geworden. Dazu sind neue Speichermaterialien notwendig sind, wofür sich in vielen Fällen polymere schaltbare Materialien eignen.Aus diesem Grunde wurden in der vorliegenden Arbeit polymergebundene Nitrone hergestellt, um diese als photoreaktives ...
openaire   +3 more sources

Emerging Therapeutic Strategies for Hearing Loss

Advanced Therapeutics, Volume 8, Issue 7, July 2025.
Challenges still exist in treating hearing loss in cases of severe damage to hair cells or spiral ganglion neurons. Here, a schematic diagram of cochlear sensory hair cells and auditory nerves is presented. It is found that in normal Corti organs, hair cells have upright stereocilia at the top and auditory neurons at the base. Ototoxic drugs, noise, or
Shanying Han, Tian Shen, Weiwei He, Hao Wei, Xiaolong Zhao, Wen Yang, Chuan Bu, Xinghua Tang, Yu Zhao, Jiangang Fan   +9 more
wiley   +1 more source

Nitrone spin trap lipophilicity as a determinant for inhibition of low density lipoprotein oxidation and activation of interleukin-1 beta release from human monocytes.

Journal of Lipid Research, 1994
One means by which oxidation of low density lipoproteins (LDL) may contribute to atherogenesis is by their ability to induce the release of interleukin-1 beta from monocytes.
C E Thomas, G Ku, B Kalyanaraman
doaj   +1 more source

Fluorescent Antibiotics: Bridging Diagnostic and Therapy in the Fight against Bacterial Infections

Small Science, Volume 5, Issue 7, July 2025.
This review critically evaluates fluorescent antibiotics as promising agents combining diagnostic precision with therapeutic efficacy. It highlights advances in probe design, chemical conjugation strategies, real‐time imaging applications, selective pathogen detection, and targeted therapy. The potential to combat antimicrobial resistance is discussed,
Tan Phuoc Ton, Richard Bright, Vi Khanh Truong, Krasimir Vasilev   +3 more
wiley   +1 more source

Valdiazen Derivatives for Chemoproteomic Studies in Burkholderia cenocepacia H111

ChemBioChem, Volume 26, Issue 11, June 3, 2025.
Valdiazen is a quorum‐sensing signal isolated from B. c. H111. Using diazeniumdiolate chemical probes, several valdiazen‐binding proteins are identified, many of which are involved in structural and metabolic processes. This study offers valuable chemical tools and advances our understanding of the interactome associated with diazeniumdiolate signaling
Jiajun Ren, Anugraha Mathew, María Rodríguez‐García, Colin C. Regli, Olivier Blacque, Bernhard Spingler, Simon Sieber, Leo Eberl, Karl Gademann   +8 more
wiley   +1 more source

Imaging free radicals in organelles, cells, tissue, and in vivo with immuno-spin trapping

Redox Biology, 2016
The accurate and sensitive detection of biological free radicals in a reliable manner is required to define the mechanistic roles of such species in biochemistry, medicine and toxicology.
Ronald Paul Mason
doaj   +1 more source

Mechanochemistry: Fundamental Principles and Applications

Advanced Science, Volume 12, Issue 24, June 26, 2025.
In this review, the physicochemical principles of mechanochemistry are first clarified. Based on this foundation, the research basis and cutting‐edge scientific achievements in four areas are introduced: solid‐state organic chemistry, polymers, interface science, and biomechanochemistry.
Liang Dong, Luofei Li, Huiyan Chen, Yi Cao, Hai Lei   +4 more
wiley   +1 more source