Results 21 to 30 of about 1,746 (206)

The In Vitro Transgenic Rodent Assay in Primary MutaMouse Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the HPRT Gene

Environmental and Molecular Mutagenesis, EarlyView.
ABSTRACT Gene mutations can be detected in mammalian cells in vitro using indicator genes such as the hypoxanthine‐guanine‐phosphoribosyltransferase (HPRT) gene. These assays have been adopted as OECD test guidelines (TG, e.g., OECD TG no. 476) and are used for regulatory purposes.
Alina Göpfert, Kylee Kendra Marie Ronnenberg, Claudia Ruelker, Silke Spang, Naveed Honarvar, Robert Landsiedel   +5 more
wiley   +1 more source

Structure-Activity Relationships of Nitroarenes: Mutagenicity, Oxygen Consumption, Toxicity, and Xenobiotic Radical Production. [PDF]

, 1997
The nitroreduction of 4NQO and five structural analogs were studied with respect to radical production and mutagenicity. In the umu assay, 4NQO was the most mutagenic analog.
Metosh-dickey, Caroline Ann
core   +2 more sources

An In Vitro and In Vivo Assessment of the Genotoxic Potential of Maizinol (UP165), a Zea mays Leaf Extract

Journal of Applied Toxicology, EarlyView.
ABSTRACT Benzoxazinoids are secondary metabolites produced in monocotyledons and some dicotyledons from the Acanthaceae, Ranunculaceae, Scrophulariaceae, Plantaginaceae, and Lamiaceae families. Benzoxazinoids are commonly consumed in bread and cereal products that have been ingested for decades, which supports the safe use of benzoxazinoids as food ...
J. Kyle Weston, Barry S. Lynch, James A. Akingbasote   +2 more
wiley   +1 more source

FB23‐2 and Cisplatin Synergize to Inhibit Head and Neck Squamous Cell Carcinoma by Targeting the XPF/ERCC1 Complex

Cancer Science, EarlyView.
FB23‐2 potentiates cisplatin's antitumor efficacy in head and neck squamous cell carcinoma by disrupting XPF/ERCC1 complex assembly and nuclear translocation, thereby suppressing DNA damage repair machinery and amplifying platinum‐induced tumor cell death.
Yaoqi Jiang, Hongshi Cai, Yue Zhu, Jianfeng Liang, Hongyu Li, Fan Song, Ziyi Wang, Jinsong Hou   +7 more
wiley   +1 more source

Optimized Lanthanide(III) Tags for Rapid and Efficient Protein Labeling in Electron Paramagnetic Resonance and Luminescence Applications

ChemistryEurope, Volume 4, Issue 1, January 2026.
Three novel Ln(III) complexes for efficient, site‐specific cysteine labeling under mild aqueous conditions are reported. A kinetic study reveals how subtle changes to the reactive pendant arm tune tagging rates, with Tb.QuNO achieving >95% cysteine labeling in 10 min.
Lydia Topping, Elena M. Mocanu, S. Ronan Fisher, Robert I. Hunter, Yasmin Ben‐Ishay, Daniella Goldfarb, Graham M. Smith, Janet E. Lovett, Stephen J. Butler   +8 more
wiley   +1 more source

Toxic Evaluations of Calea phyllolepis Extracts Standardized on 6‐epi‐β‐Verbesinol Coumarate and Its In Silico Prediction of the Toxicity

Chemistry &Biodiversity, Volume 22, Issue 12, December 2025.
In vivo and in silico toxicological effects of Calea phyllolepis extracts Standardized on 6‐epi‐β‐Verbesinol Coumarate. ABSTRACT Medicinal plants are traditionally used in folk medicine. Still, there is a misconception about the safety/efficacy of natural treatments, which results in few studies on the toxic, genotoxic, and mutagenic potential of ...
Suele Bierhals Vencato, Guilherme Borsoi, Cleverson Feistel, Mariele Feiffer Charão, Angélica Rocha Joaquim, Jaqueline Nascimento Picada, Alexandre de Barros Falcão Ferraz   +6 more
wiley   +1 more source

Single‐Cell RNA‐Seq Reveals the Effect of Commensal Bacteria on the Multistep Development of Esophageal Cancer

Cancer Science, Volume 116, Issue 12, Page 3337-3351, December 2025.
These results shed light on the impact of commensal microbiome on phenotypes and transition fates of different cell types across the tumorigenic processes of ESCC and may have implications for ESCC prevention and treatment. ABSTRACT Microbiomes within the tumor microenvironment (TME) are intricately linked to the modulation of cancer cell properties ...
Xuan Xie, Shuyue Zhang, Zihang Mai, Jing Zhan, Sheng Lei, Zhiqiang Ouyang, Zelin Weng, Xiuying Xie, Jingjing Han, Jing Wen   +9 more
wiley   +1 more source

Safety evaluation of jagua (genipin‐glycine) blue as a food additive

EFSA Journal, Volume 23, Issue 12, December 2025.
Abstract The EFSA Panel on Food Additives and Flavourings (FAF Panel) provides a scientific opinion on the safety of jagua (genipin‐glycine) blue as a new food additive. Jagua (genipin‐glycine) blue is obtained by water extraction of the ground pulp of the peeled, unripe fruits of Genipa americana L.
EFSA Panel on Food Additives and Flavourings (FAF), Laurence Castle, Monica Andreassen, Gabriele Aquilina, Maria Lourdes Bastos, Polly Boon, Biagio Fallico, Reginald FitzGerald, Maria Jose Frutos Fernandez, Bettina Grasl‐Kraupp, Ursula Gundert‐Remy, Rainer Gürtler, Eric Houdeau, Marcin Kurek, Henriqueta Louro, Patricia Morales, Sabina Passamonti, José Manuel Barat Baviera, Gisela Degen, David Gott, Jean‐Charles Leblanc, Peter Moldeus, Ine Waalkens‐Berendsen, Detlef Wölfle, Consuelo Civitella, Agnieszka Mech, Concepción Medrano‐Padial, Alexandra Tard, Panagiota Zakidou, Laura Ruggeri   +29 more
wiley   +1 more source

Copper‐Catalyzed Hydrosilylation of Nitroarenes: Chemoselective Reduction to Aromatic Amines

ChemCatChem, Volume 17, Issue 22, November 24, 2025.
A commercially available copper‐hydride complex was utilized as an effective catalyst for the hydrosilylation of nitroarenes to aromatic amines. Nitroarenes with diverse functionalities were efficiently reduced to anilines with good chemoselectivity. The practicality of this reduction protocol was demonstrated through the synthesis of pharmaceuticals ...
Pritirekha Mallick, Ratiraman Swain, Swetarani Meher, Subrat Sethi, Bidraha Bagh   +4 more
wiley   +1 more source

Synthesis of heterocyclic bases derived from m-phenanthroline of possible antimalarial activity [PDF]

, 1941
#I. A survey of the literature dealing with antimalarial compounds is given, with special reference to the relationship between chemotherapeutic activity and chemical constitution. #II.
Webster, William
core