Results 181 to 190 of about 26,472 (210)

Enzymatic Reduction of 3-Nitrotyrosine Generates Superoxide

Chemical Research in Toxicology, 1998
Spin-trapping with 5,5-dimethyl-1-pyrroline 1-oxide (DMPO) was used to demonstrate that 3-nitrotyrosine (nitrotyrosine) promotes the formation of substantial amounts of reactive oxygen species (O2.- and *OH), when incubated with NAD(H)-cytochrome c reductase and a corresponding electron donor. Spin adduct formation is strongly inhibited by the presence
A G, Krainev, T D, Williams, D J, Bigelow   +2 more
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Plasma nitrotyrosine levels, antioxidant vitamins and hyperglycaemia

Diabetic Medicine, 2005
AbstractAims  Studies on plasma nitrotyrosine (NT) levels, a measure of oxidative injury, in diabetes are limited and discordant; the amount of antioxidants might represent a possible explanation for the discordant results. The aim of this paper is to evaluate the association between plasma NT levels and glucose tolerance status, according to ...
BO, Simona, GAMBINO, Roberto, S. GUIDI, B. SILLI, L. GENTILE, CASSADER, Maurizio, PAGANO, Gian Franco   +6 more
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Nitrotyrosine formation in splenic toxicity of aniline

Toxicology, 2003
Splenic toxicity of aniline is characterized by vascular congestion, hyperplasia, fibrosis and development of a variety of sarcomas in rats. However, the mechanisms of this selective splenic toxicity are not well understood. Previously we showed that aniline exposure causes oxidative damage to spleen.
M Firoze, Khan, Xiaohong, Wu, Bhupendra S, Kaphalia, Paul J, Boor, G A S, Ansari   +4 more
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Effects of diabetes on plasma nitrotyrosine levels

Diabetic Medicine, 2004
AbstractBackground  Oxidative stress plays a major role in disease processes such as atherosclerosis and diabetes. Peroxynitrite is a reaction product of nitric oxide (NO) and superoxide and a potent oxidant. The peroxynitrite‐mediated tyrosine nitration, which forms nitrotyrosine (NT), is associated with several pathological conditions.Methods  We ...
X L, Wang, D L, Rainwater, A, Leone, M C, Mahaney   +3 more
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Circulating free nitrotyrosine in obstructive sleep apnea

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2004
Obstructive sleep apnea (OSA) has been increasingly linked to cardiovascular disease, endothelial dysfunction, and oxidative stress, generated by repetitive nocturnal hypoxemia and reperfusion. Circulating free nitrotyrosine has been reported as a novel biomarker of nitric oxide (NO)-induced oxidative/nitrosative stress.
Anna, Svatikova, Robert, Wolk, Hui H, Wang, Maria E, Otto, Kevin A, Bybee, Ravinder J, Singh, Virend K, Somers   +6 more
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Sulfation of nitrotyrosine: Biochemistry and functional implications

IUBMB Life, 2007
AbstractNitration of tyrosine, in both protein‐bound form and free amino acid form, can readily occur in cells under oxidative/nitrative stress. In addition to serving as a biomarker of oxidative/nitrative stress, elevated levels of nitrotyrosine have been shown to cause DNA damage or trigger apoptosis.
Ming-Cheh, Liu, Shin, Yasuda, Steven, Idell   +2 more
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Nitrotyrosine Residues in Placenta

Hypertension, 1996
The interaction of nitric oxide and superoxide produces peroxynitrite anion, a strong, long-lived oxidant with pronounced deleterious effects that may cause vascular damage. The formation and action of peroxynitrite can be detected by immunohistochemical localization of nitrotyrosine residues.
L, Myatt, R B, Rosenfield, A L, Eis, D E, Brockman, I, Greer, F, Lyall   +5 more
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Nitrotyrosine internal standard for amino acid analysis

Analytical Biochemistry, 1975
Abstract 3-Nitrotyrosine is shown to be suitable as an internal standard for amino acid analysis. It is stable to acid hydrolysis, gives a color yield of 1.01 with ninhydrin which obeys Beer's Law, elutes in a position which is resolved from other amino acids on both Spinco and Durrum amino acid analyzers, and is commercially available.
R W, Giese, J F, Riordan
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Nitrotyrosine localization to dermal nerves in borderline leprosy

British Journal of Dermatology, 2004
Nerve damage is a common and disabling feature of leprosy, with unclear aetiology. It has been reported that the peroxidizing agents of myelin lipids-nitric oxide (NO) and peroxynitrite-are produced in leprosy skin lesions.To investigate the localization of nitrotyrosine (NT)-a local end-product of peroxynitrite-in leprosy lesions where dermal nerves ...
T, Schön, R, Hernández-Pando, J, Baquera-Heredia, Y, Negesse, L E, Becerril-Villanueva, J C L, Eon-Contreras, T, Sundqvist, S, Britton   +7 more
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Immunohistochemical methods to detect nitrotyrosine.

Methods in enzymology, 1999
The immunohistochemical detection of nitrotyrosine is a robust method for detecting peroxynitrite and other reactive nitrogen species. Success depends on optimizing conditions for the particular tissue and experimental design under investigation and the use of positive and negative controls to verify specificity.
L, Viera, Y Z, Ye, A G, Estévez, J S, Beckman   +3 more
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