Results 181 to 190 of about 18,603 (231)

Lipopolysaccharide-induced increase in plasma nitrotyrosine concentrations in rats [PDF]

Biochimica Et Biophysica Acta - Molecular Basis of Disease, 1997
Since the production of peroxynitrite may contribute to the pathophysiology of endotoxemia or sepsis, the quantities of the produced peroxynitrite were evaluated in rats after lipopolysaccharide (LPS) treatment by measuring plasma nitrotyrosine ...
Kumiyo Ashida, Kentaro Nakamoto, Yoshinori Kamisaki   +2 more
exaly   +2 more sources

Characterization of nitrotyrosine as a biomarker for arthritis and joint injury [PDF]

Osteoarthritis and Cartilage, 2013
To characterize the utility of nitrotyrosine (NT) as a biomarker for arthritis and joint injury.Synovial fluid, plasma, and urine from patients diagnosed with osteoarthritis (OA), rheumatoid arthritis (RA), anterior cruciate ligament (ACL) injury, meniscus injury and pseudogout, and knee-healthy volunteers were analyzed for concentrations of NT ...
Thomas Miško, M P Hellio le Graverand, C Bramson   +2 more
exaly   +4 more sources

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Nitrotyrosine in Otitis Media with Effusion

Annals of Otology, Rhinology & Laryngology, 2005
Objectives: Our purpose was to investigate mucosal cell injury due to the nitric oxide (NO)-superoxide system in otitis media with effusion. Methods: We determined the levels of nitrotyrosine (NT) and NO and the activities of ...
Ken-ichi, Hisamatsu, Hajime, Inoue, Kiyoshi, Makiyama, Masami, Homma   +3 more
openaire   +2 more sources

Plasma 3-Nitrotyrosine in Cigarette Smokers

American Journal of Respiratory and Critical Care Medicine, 1997
Abstract Peroxynitrite has been associated with increased oxidative reactions and DNA damage in inflamed tissues as it may cause a reduction of plasma antioxidants as well. Nitration of tyrosine residues of proteins leads to the production of 3-nitrotyrosine (NTYR), which may be considered as a marker of NO · -dependent oxidative ...
PETRUZZELLI S, PUNTONI R, MIMOTTI P, PULERA N, BALIVA F, FORNAI E, GIUNTINI, CARLO   +6 more
openaire   +3 more sources

3-Nitrotyrosine in Atherosclerotic Blood Vessels

Clinical Chemistry and Laboratory Medicine, 2003
The effect of peroxynitrite on the development of atherosclerosis is one of the major foci of recent studies. Here, the cytotoxic effect of peroxynitrite was investigated by quantitatively measuring nitrated tyrosine, 3-nitrotyrosine (3-NT) levels in atherosclerotic blood vessels.
Nehir, Sucu, Ali, Unlü, Lülüfer, Tamer, Barlas, Aytacoglu, Bahadir, Ercan, Murat, Dikmengil, Ugur, Atik   +6 more
openaire   +2 more sources

Effects of diabetes on plasma nitrotyrosine levels

Diabetic Medicine, 2004
AbstractBackground  Oxidative stress plays a major role in disease processes such as atherosclerosis and diabetes. Peroxynitrite is a reaction product of nitric oxide (NO) and superoxide and a potent oxidant. The peroxynitrite‐mediated tyrosine nitration, which forms nitrotyrosine (NT), is associated with several pathological conditions.Methods  We ...
X L, Wang, D L, Rainwater, A, Leone, M C, Mahaney   +3 more
openaire   +2 more sources

Nitrotyrosine formation in splenic toxicity of aniline

Toxicology, 2003
Splenic toxicity of aniline is characterized by vascular congestion, hyperplasia, fibrosis and development of a variety of sarcomas in rats. However, the mechanisms of this selective splenic toxicity are not well understood. Previously we showed that aniline exposure causes oxidative damage to spleen.
M Firoze, Khan, Xiaohong, Wu, Bhupendra S, Kaphalia, Paul J, Boor, G A S, Ansari   +4 more
openaire   +2 more sources

Anti-Nitrotyrosine Antibodies for Immunohistochemistry

2003
Nitrotyrosine is an important marker for the formation of peroxynitrite and possibly other reactive nitrogen species derived from nitric oxide in vivo (1). Pathological conditions can substantially increase the production of nitric oxide, yet this molecule itself does not generally yield nitration of tyrosine residues in proteins when added to ...
L, Viera, Y Z, Ye, J S, Beckman
openaire   +2 more sources

Sulfation of nitrotyrosine: Biochemistry and functional implications

IUBMB Life, 2007
AbstractNitration of tyrosine, in both protein‐bound form and free amino acid form, can readily occur in cells under oxidative/nitrative stress. In addition to serving as a biomarker of oxidative/nitrative stress, elevated levels of nitrotyrosine have been shown to cause DNA damage or trigger apoptosis.
Ming-Cheh, Liu, Shin, Yasuda, Steven, Idell   +2 more
openaire   +2 more sources

Quantitative Proteome Mapping of Nitrotyrosines

2008
An essential first step in the understanding disease and environmental perturbations is the early and quantitative detection of the increased levels of the inflammatory marker nitrotyrosine, as compared with its endogenous levels within the tissue or cellular proteome.
Diana J, Bigelow, Wei-Jun, Qian
openaire   +2 more sources