A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury [PDF]
, 2014 Background Many diseases and pathological conditions are characterized by transient or constitutive overproduction of reactive oxygen species (ROS).
Ashraf, Muhammad Imtiaz +17 more
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In Vitro Induction and Characterization of Polyploid Hydrangea macrophylla and H. serrata
HortScience, 2021 Hydrangea macrophylla (Thunb.) Ser. and H. serrata (Thunb.) Ser. are popular and commercially important landscape and floriculture crops. Although both species are typically diploid, induced polyploids often exhibit horticulturally valuable traits ...
Lauren E. Deans +3 more
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Crucial role of local peroxynitrite formation in neutrophil-induced endothelial cell activation [PDF]
, 2003 Introduction and methods: The reaction of superoxide anions and NO not only results in a decreased availability of NO, but also leads to the formation of peroxynitrite, the role of which in the cardiovascular system is still discussed controversially. In
Gloe, Torsten +8 more
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Mass spectrometry analysis of nitrotyrosine‐containing proteins [PDF]
Mass Spectrometry Reviews, 2013 AbstractOxidative stress plays important roles in a wide range of diseases such as cancer, inflammatory disease, neurodegenerative disorders, etc. Tyrosine nitration in a protein is a chemically stable oxidative modification, and a marker of oxidative injuries.
Xianquan, Zhan +2 more
openaire +2 more sources
A modern view on potential biomarkers of Parkinson’s disease (review)
Patologìâ, 2020 Parkinson’s disease (PD) is one of the most widespread neurodegenerative diseases. In spite of the large number of researches, the problem of earlier diagnosis and targeted pathogenetic therapy remains relevant.
A. V. Demchenko , V. V. Biriuk
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Superoxide dismutase analog (Tempol: 4-hydroxy-2, 2, 6, 6-tetramethylpiperidine 1-oxyl) treatment restores erectile function in diabetes-induced impotence. [PDF]
, 2009 We hypothesized that the administration of the superoxide dismutase (SOD) mimetic Tempol (4-hydroxy-2, 2, 6, 6-tetramethylpiperidine 1-oxyl) may reverse diabetes-induced erectile dysfunction. To test this hypothesis, reactive oxygen species-related genes
Dahiya, R +12 more
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Pros and cons of current approaches for detecting peroxynitrite and their applications
Biomedical Journal, 2014 Peroxynitrite, a representative of reactive nitrogen species, plays important roles in the physiological and pathological processes of many oxidative stress-related diseases.
Xingmiao Chen +3 more
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The Induction of Oxidative/Nitrosative Stress, Inflammation, and Apoptosis by a Ferric Carboxymaltose Copy Compared to Iron Sucrose in a Non-Clinical Model [PDF]
, 2015 Introduction: Ferric carboxymaltose is a next-generation polynuclear iron(III)-hydroxide carbohydrate complex for intravenous iron therapy belonging to the class of so-called non-biological complex drugs.
Angerosa, Margarita +2 more
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Uric acid enhances longevity and endurance and protects the brain against ischemia [PDF]
, 2020 Among mammals, there is a positive correlation between serum uric acid (UA) levels and life span. Humans have high levels of UA because they lack a functional urate oxidase (UOX) enzyme that is present in shorter lived mammals.
Argüelles Castilla, Sandro +6 more
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Frontiers in Chemistry, 2016 Nitration of tyrosine and other aromatic amino acid residues in proteins occurs in the setting of inflammatory, neurodegenerative and cardiovascular diseases – importantly, this modification has been implicated in the pathogenesis of diverse diseases and
Tal eNuriel +7 more
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