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Nitroxolin – mikrobiologische und pharmakokinetische Aspekte
2015Akute Harnwegsinfektionen (HWI) gehören zu den häufigen Infektionskrankheiten. Die Behandlung mit Standardantibiotika ist aufgrund steigender Resistenzen bei Escherichia coli (ECO) und anderen uropathogenen Bakterien in den letzten 10–15 Jahren zunehmend schwieriger geworden [ref:1].[for full text, please go to the a.m. URL]
Kresken, M, Körber-Irrgang, B
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Use of galvanostatic coulometry for determining nitroxoline
Journal of Analytical Chemistry, 2007It was found that nitroxoline rapidly and quantitatively reacts with electrogenerated chlorine or bromine. The stoichiometric coefficients of these reactions are 1: 1.5 and 1: 1, respectively. The mechanism of the reaction of nitroxoline with electrogenerated bromine was proposed.
Shlyamina O. +3 more
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[Present status of nitroxoline].
Pathologie-biologie, 1987Nitroxoline (8-hydroxy-5-nitroquinoline) has been used since 1962 in the treatment of urinary tract infections especially those due to gram negative bacilli (E. coli). The current renewal of the drug is in relation to the recently shown activity of nitroxoline against fungi (Candida, Torulopsis), Mycoplasma and U.
E, Bergogne-Berezin +2 more
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Clinical pharmacokinetics of nitroxoline.
International journal of clinical pharmacology and biopharmacy, 198014C-Nitroxoline was given orally to the rats, and its distribution as well as plasma and bile levels were determined autoradiographically and by the aid of radioactivity measurements, respectively. Nitroxoline was also given to the human volunteers orally and intravenously in three various doses and the corresponding urine concentrations of ...
A, Mrhar +4 more
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Production control of nitroxoline by spectrophotometric method
Pharmaceutical Chemistry Journal, 1978Data of the spectrophotometric determination of 8-hydroxyquinoline are given in Table i. Determination Procedure. Approximately 0.2 g of the 8-hydroxyquinoline paste (accurately weighed) is placed in a i00 ml volumetric flask and dissolved in I0 ml of alcohol and the water is added up to the mark.
L. I. Koloskova +2 more
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Cathepsin B inhibitors: Further exploration of the nitroxoline core
Bioorganic & Medicinal Chemistry Letters, 2018Human cathepsin B is a cysteine protease with many house-keeping functions, such as intracellular proteolysis within lysosomes. Its increased activity and expression have been strongly associated with many pathological processes, including cancers. We present here the design and synthesis of novel derivatives of nitroxoline as inhibitors of cathepsin B.
Izidor Sosič +7 more
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Rediscovering nitroxoline: a metal-chelating agent bridging infection and cancer
Drug Discovery TodayNitroxoline, a legacy antimicrobial agent, is gaining attention for its potential repurposing in infectious diseases and oncology. Its broad-spectrum activity, including biofilm disruption and metal-chelating properties, supports diverse therapeutic applications.
Praveen Papareddy +2 more
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Nitroxoline shows antimyeloma activity by targeting the TRIM25/p53 axle
Anti-Cancer Drugs, 2017The aim of this study was to identify the most potent quinoline-based anti-infectives for the treatment of multiple myeloma (MM) and to understand the molecular mechanisms. A small-scale screen against a panel of marketed quinoline-based drugs was performed in MM cell lines. Cell apoptosis was examined by flow cytometry.
Hongwu, Mao +6 more
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High-performance liquid chromatographic analysis of nitroxoline in plasma and urine
Journal of Chromatography B: Biomedical Sciences and Applications, 1981A high-performance liquid chromatographic method has been developed for the determination of nitroxoline in 50-microliter plasma and urine samples. A structural analogue of nitroxoline, 8-hydroxyquinoline, was added to the eluent in order to suppress peak asymmetry.
R H, Sorel, C, Snelleman, A, Hulshoff
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Effects of subinhibitory concentrations of nitroxoline on the surface properties ofEscherichia coli
Folia Microbiologica, 2000Nitroxoline (5-nitro-8-quinolinol; NIQ) at subinhibitory concentrations (sub-MIC) decreased the adherence of uropathogenic Escherichia coli to catheter surface and significantly enhanced cell surface hydrophobicity. The surface hydrophobicity increased in the presence of sub-MIC of NIQ and also in an excess of Mg2+.
H, Latrache +4 more
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