Results 41 to 50 of about 645 (152)

Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen Balamuthia mandrillaris

mBio, 2018
Balamuthia mandrillaris is a pathogenic free-living amoeba that causes a rare but almost always fatal infection of the central nervous system called granulomatous amoebic encephalitis (GAE). Two distinct forms of B.
Matthew T. Laurie, Corin V. White, Hanna Retallack, Wesley Wu, Matthew S. Moser, Judy A. Sakanari, Kenny Ang, Christopher Wilson, Michelle R. Arkin, Joseph L. DeRisi   +9 more
doaj   +1 more source

BRD4 inhibitor nitroxoline enhances the sensitivity of multiple myeloma cells to bortezomib and by promoting mitochondrial pathway-mediated cell apoptosis

Therapeutic Advances in Hematology, 2020
Background: Multiple myeloma (MM) is the second most common hematological neoplasm. Wide administration of bortezomib significantly improves the survival of MM patients compared with conventional chemotherapy.
Guang Li, Yan-Hua Zheng, Li Xu, Juan Feng, Hai-Long Tang, Cheng Luo, Yan-Ping Song, Xie-Qun Chen   +7 more
doaj   +1 more source

The anti‐infection drug furazolidone inhibits NF‐κB signaling and induces cell apoptosis in small cell lung cancer

The Kaohsiung Journal of Medical Sciences, Volume 36, Issue 12, Page 998-1003, December 2020., 2020
Abstract Targeting nuclear factor kappa B (NF‐κB) signaling pathway has become a promising strategy for the development of new antitumor drugs. In this paper, we found that anti‐infection drug furazolidone (FZD) could significantly inhibit NF‐κB‐driven luciferase activity, and FZD could markedly inhibit both of the constitutive and tumor necrosis ...
Jin‐Guo Yu, Cheng‐Hong Ji, Min‐Hua Shi   +2 more
wiley   +1 more source

Nitroxoline

, 2019
Antimicrobial resistance has become a prime global concern. An ability of the microbes to produce enzymes to destroy antimicrobial drugs is one of the well-known mechanisms underlying the resistance. 8-Hydroxyquinoline (8HQ) and derivatives were reported to exert diverse biological effects such as antimicrobial, antioxidant and an- tineurodegenerative ...
Cherdtrakulkiat, Rungrot, Lawung, Ratana, Nabu, Sunanta, Tantimavanich, Srisurang, Sinthupoom, Nujarin, Prachayasittikul, Supaluk, Prachayasittikul, Virapong   +6 more
openaire   +2 more sources

Effect of Nitroxoline on Angiogenesis and Growth of Human Bladder Cancer [PDF]

JNCI: Journal of the National Cancer Institute, 2010
Angiogenesis plays an important role in tumor growth and metastasis; therefore, inhibition of angiogenesis is a promising strategy for developing new anticancer drugs. Type 2 methionine aminopeptidase (MetAP2) protein is likely a molecular target of angiogenesis inhibitors.Nitroxoline, an antibiotic used to treat urinary tract infections, was ...
Joong Sup, Shim, Yoshiyuki, Matsui, Shridhar, Bhat, Benjamin A, Nacev, Jing, Xu, Hyo-eun C, Bhang, Surajit, Dhara, Kee Chung, Han, Curtis R, Chong, Martin G, Pomper, Alan, So, Jun O, Liu   +11 more
openaire   +2 more sources

Susceptibility of carbapenemase-producing Enterobacterales (CPE) to nitroxoline

Journal of Antimicrobial Chemotherapy, 2019
AbstractBackgroundInfections caused by carbapenemase-producing Enterobacterales (CPE) constitute a major global health concern and are associated with increased morbidity and mortality. Nitroxoline is an old antibiotic, which has recently been re-launched for the treatment of uncomplicated urinary tract infection.
Frieder Fuchs, Axel Hamprecht
openaire   +2 more sources

In Vitro Selective Combinatory Effect of Ciprofloxacin with Nitroxoline, Sanguinarine, and Zinc Pyrithione against Diarrhea-Causing and Gut Beneficial Bacteria

Microbiology Spectrum, 2022
Antibiotic resistance in diarrhea-causing bacteria and its disruption of gut microbiota composition are health problems worldwide. The development of combinatory agents that increase the selective inhibitory effect (synergism) against diarrheagenic ...
Hayford Osei-Owusu, Tomas Kudera, Marie Strakova, Johana Rondevaldova, Eva Skrivanova, Pavel Novy, Ladislav Kokoska   +6 more
doaj   +1 more source

Nitroxoline induces apoptosis and slows glioma growth in vivo [PDF]

Neuro-Oncology, 2014
Nitroxoline is an FDA-approved antibiotic with potential antitumor activity. Here we evaluated whether nitroxoline has antiproliferative properties on glioma cell growth in vitro and in vivo using glioma cell lines and a genetically engineered PTEN/KRAS mouse glioma model.The effect of nitroxoline treatment on U87 and/or U251 glioma cell proliferation,
Lazovic, Jelena, Guo, Lea, Nakashima, Jonathan, Mirsadraei, Leili, Yong, William, Kim, Hyun J, Ellingson, Benjamin, Wu, Hong, Pope, Whitney B   +8 more
openaire   +4 more sources

In Vitro Selective Growth-Inhibitory Activities of Phytochemicals, Synthetic Phytochemical Analogs, and Antibiotics against Diarrheagenic/Probiotic Bacteria and Cancer/Normal Intestinal Cells

Pharmaceuticals, 2020
A desirable attribute of novel antimicrobial agents for bacterial diarrhea is decreased toxicity toward host intestinal microbiota. In addition, gut dysbiosis is associated with an increased risk of developing intestinal cancer.
Tomas Kudera, Ivo Doskocil, Hana Salmonova, Miloslav Petrtyl, Eva Skrivanova, Ladislav Kokoska   +5 more
doaj   +1 more source

Susceptibility of Aerococcus urinae and Aerococcus sanguinicola to Standard Antibiotics and to Nitroxoline

Microbiology Spectrum, 2023
A. urinae and A. sanguinicola have been increasingly recognized as causative agents in urinary tract infections. Currently, there are few data available on the activity of different antibiotics against these species and no data on nitroxoline.
Aysel Ahmadzada, Frieder Fuchs, Axel Hamprecht   +2 more
openaire   +2 more sources