Results 21 to 30 of about 645 (152)

Prescription of antibiotics for urinary tract infections in outpatient care in Bavaria: An analysis of routine data. [PDF]

PLoS ONE
BackgroundPatients with urinary tract infection (UTI) in German outpatient care are usually treated by general practitioners (GPs), as well as by other specialties.
Thomas Hanslmeier, Sahera Alsaiad, Susann Hueber, Peter K Kurotschka, Roman Gerlach, Ildikó Gágyor, Yvonne Kaußner   +6 more
doaj   +2 more sources

Synthesis, characterization and theoretical studies of nitroxoline azo dye metal complexes and their role in mitigation of rheumatoid arthritis [PDF]

Scientific Reports
In this work, an azo dye ligand of 2,6-dichloroaniline with nitroxoline (CPAQ), and its Zn(II), Cu(II), Cd(II), Ni(II) and Co(II) complexes have been synthesized.
Hoda A. El-Ghamry, Mohamed Gaber, Mariam S. Napolion, Amira Atta, Tarek M. Mohamed, Nadia A. El‐Wakiel   +5 more
doaj   +2 more sources

Challenges and advances in the medical treatment of granulomatous amebic encephalitis [PDF]

Therapeutic Advances in Infectious Disease
Granulomatous amebic encephalitis, caused by the free-living amebae Balamuthia mandrillaris or Acanthamoeba species, is a rare and deadly infectious syndrome with a current mortality rate of >90%.
Natasha Spottiswoode, Julia C. Haston, Natasha W. Hanners, Katherine Gruenberg, Annie Kim, Joseph L. DeRisi, Michael R. Wilson   +6 more
doaj   +2 more sources

Modelling amoebic brain infection caused by Balamuthia mandrillaris using a human cerebral organoid. [PDF]

PLoS Neglected Tropical Diseases
The lack of disease models adequately resembling human tissue has hindered our understanding of amoebic brain infection. Three-dimensional structured organoids provide a microenvironment similar to human tissue.
Nongnat Tongkrajang, Porntida Kobpornchai, Pratima Dubey, Urai Chaisri, Kasem Kulkeaw   +4 more
doaj   +2 more sources

In Vitro Activity of Nitroxoline (5-Nitro-8-Hydroxyquinoline) Against Aspergillus Species. [PDF]

Mycoses
ABSTRACT Background Nitroxoline is an old antibiotic currently approved for the treatment of uncomplicated urinary tract infections. Its mode of action is based on the chelation of bivalent cations, such as zinc. Objectives As zinc plays a central role in the metabolism of Aspergillus spp., we performed antifungal susceptibility testing against ...
Hoffmann A, Cornely OA, Vonhoegen J, Sprute R, Reinhold I, Walther G, Fuchs F, Simon M.   +7 more
europepmc   +2 more sources

Multipotential use of an old drug, as a new solution for anticancer therapy and multidrug-resistant urinary tract infections

Journal of Education, Health and Sport, 2023
Introduction        Nitroxoline (NTX) is a well-known chemotherapeutic agent that has been used to treat urinary tract infections since the 1960s. Today, the incidence of multidrug-resistant (MDR) bacterial strains is on the rise worldwide.
Patryk Banaś, Kamila Abram, Justyna Adamus, Jakub Rafał Pierzchała, Katarzyna Bednarz, Natalia Sobańska, Aleksandra Paulina Banasiak, Rafał Teichman, Jakub Kasprowicz, Michał Hyjek   +9 more
doaj   +1 more source

In vitro Activity of Repurposed Nitroxoline Against Clinically Isolated Mycobacteria Including Multidrug-Resistant Mycobacterium tuberculosis

Frontiers in Pharmacology, 2022
Antimicrobial treatment options for mycobacterial infections are limited due to intrinsic resistance and the emergence of acquired resistance in Mycobacterium tuberculosis.
Ada Marie Hoffmann, Martina Wolke, Jan Rybniker, Jan Rybniker, Georg Plum, Frieder Fuchs, Frieder Fuchs   +6 more
doaj   +1 more source

Nitroxoline Drug Combinations Are More Active Than Lyme Antibiotic Combination and Can Eradicate Stationary-Phase Borrelia burgdorferi

Infectious Microbes & Diseases, 2022
. Lyme disease (LD), caused by Borrelia burgdorferi, is the most common vector-borne disease in the United States and Europe. Despite the standard 2–4 weeks' antibiotic treatment, approximately 10%–20% of patients will develop posttreatment LD syndrome ...
Hector S. Alvarez-Manzo, Yumin Zhang, Ying Zhang   +2 more
doaj   +1 more source

Compared with Cotrimoxazole Nitroxoline Seems to Be a Better Option for the Treatment and Prophylaxis of Urinary Tract Infections Caused by Multidrug-Resistant Uropathogens: An In Vitro Study

Antibiotics, 2021
The resistance of uropathogens to various antibiotics is increasing, but nitroxoline remains active in vitro against some relevant multidrug resistant uropathogenic bacteria. E.
Ulrich Dobrindt, Haleluya T. Wami, Torsten Schmidt-Wieland, Daniela Bertsch, Klaus Oberdorfer, Herbert Hof   +5 more
doaj   +1 more source

Spectrophotometric Determination of Nitroxoline in Medicines Using the Response Surface Methodology

Учёные записки Казанского университета: Серия Естественные науки, 2023
It was shown by the conductometric study that the formation of micelles in the cetyltrimethylammonium bromide (CTAB) – dimethylsulfoxide (DMSO) – water system occurs at higher critical micelle concentrations (CMC) than in the CTAB – water system.
R. F. Bakeeva, S. Yu. Garmonov, V. D. Osipova, K. V. Chernyj, S. Yu. Mamykina, V. F. Sopin   +5 more
doaj   +1 more source