Repurposing of Nitroxoline as an Alternative Primary Amoebic Meningoencephalitis Treatment [PDF]
Antibiotics, 2023 Among the pathogenic free-living amoebae (FLA), Naegleria fowleri is the etiological agent of a fatal disease known as primary amoebic meningoencephalitis (PAM).
JOSÉ E Piñero +2 more
exaly +6 more sources
Nitroxoline is a novel inhibitor of NLRP3-dependent pyroptosis [PDF]
Cell Death DiscoveryAberrant activity of the NLR family pyrin domain containing 3 (NLRP3) inflammasome contributes to a wide range of diseases associated with acute inflammatory responses and chronic sterile inflammation.
Christina Maeder +7 more
doaj +4 more sources
Chelation in Antibacterial Drugs: From Nitroxoline to Cefiderocol and Beyond
Antibiotics, 2022 In the era of escalating antimicrobial resistance, the need for antibacterial drugs with novel or improved modes of action (MOAs) is a health concern of utmost importance.
Mirna Petković Didović +2 more
exaly +7 more sources
Contrasting In Vitro Activity of Nitroxoline Against Multidrug-Resistant Escherichia coli and Klebsiella pneumoniae Isolates from Outpatients [PDF]
AntibioticsBackground/Objectives: Antimicrobial resistance is a major public health concern, particularly among multidrug-resistant (MDR) Enterobacterales. Nitroxoline is an older antibiotic with a unique mechanism of action that has not been widely used in recent ...
Dominik Maleš +3 more
doaj +2 more sources
Synergistic Antimicrobial and Antibiofilm Activity of Nitroxoline in Combination with Hydroquinone Against Uropathogenic Enterococcus faecalis [PDF]
AntibioticsBackground: Enterococcus faecalis is a major cause of complicated urinary tract infections (UTIs), characterized by intrinsic resistance and pronounced biofilm formation.
Davorka Repac Antić +4 more
doaj +2 more sources
Nitroxoline evidence amoebicidal activity against Acanthamoeba castellanii through DNA damage and the stress response pathways [PDF]
International Journal for Parasitology: Drugs and Drug ResistanceAcanthamoeba castellanii is a widespread unicellular eukaryote found in diverse environments, including tap water, soil, and swimming pools. It is responsible for severe infections, such as Acanthamoeba keratitis and granulomatous amebic encephalitis ...
Lijun Chen +5 more
doaj +2 more sources
Induction of Programmed Cell Death in Acanthamoeba culbertsoni by the Repurposed Compound Nitroxoline [PDF]
Antioxidants, 2023 Acanthamoeba is a ubiquitous genus of amoebae that can act as opportunistic parasites in both humans and animals, causing a variety of ocular, nervous and dermal pathologies.
Rubén L. Rodríguez-Expósito +7 more
doaj +2 more sources
Repurposing Analysis of Nitroxoline (8-Hydroxy-5-nitroquinoline) as an Antichagasic Compound [PDF]
PharmaceuticalsBackground/Objectives: Chagas disease, caused by the protozoan parasite Trypanosoma cruzi, remains a major neglected tropical disease, with over six million cases concentrated, primarily in Latin America.
Carlos J. Bethencourt-Estrella +6 more
doaj +2 more sources
Disseminated Acanthamoeba Infection with Necrotic Skin Lesions and Granulomatous Vasculitis, United States [PDF]
Emerging Infectious DiseasesAn elderly man, on dupilumab therapy for asthma and sinus polyposis, sought care for necrotic skin lesions. Biopsy revealed granulomatous vasculitis and he received immunosuppressive therapy but worsened.
Maria Koshy +5 more
doaj +2 more sources
Uncovering nitroxoline activity spectrum, mode of action and resistance across Gram-negative bacteria [PDF]
Nature CommunicationsNitroxoline is a bacteriostatic quinoline antibiotic, known to form complexes with metals. Its clinical indications are limited to uncomplicated urinary tract infections, with a susceptibility breakpoint only available for Escherichia coli. Here, we test
Elisabetta Cacace +20 more
doaj +2 more sources