Unmasking Balamuthia mandrillaris Through PCR in a Case of Multifocal Brain Lesions [PDF]
Case Reports in Infectious DiseasesBalamuthia mandrillaris is a rare free-living amoeba that causes granulomatous amoebic encephalitis (GAE), a frequently fatal central nervous system infection.
Moamen Al Zoubi +8 more
doaj +3 more sources
Application of nitroxoline in urologic oncology – a review of evidence [PDF]
Contemporary OncologyThe persistence of high incidence and mortality rates associated with urologic cancers underscores the urgent need for effective and safe treatments.
Wojciech Tomczak +9 more
doaj +4 more sources
Repurposing of the antibiotic nitroxoline for the treatment of mpox
Journal of Medical Virology, 2022 Abstract The antiviral drugs tecovirimat, brincidofovir, and cidofovir are considered for mpox (monkeypox) treatment despite a lack of clinical evidence. Moreover, their use is affected by toxic side‐effects (brincidofovir, cidofovir), limited availability (tecovirimat), and potentially by resistance formation.
Denisa Bojkova +15 more
openaire +4 more sources
Primary toxicological evaluation of nitroxoline on laboratory animals. [PDF]
Medičnì Perspektivi, 2017 Nitroxoline is an effective antibacterial agent that is industrially produced by chemical and pharmaceutical enterprises in Ukraine. Parameters of its toxicity are determined under conditions of acute and subchronic toxicological experiments on 3 kinds ...
G. I. Yaskiv
doaj +7 more sources
Urosepsis by multidrug-resistant Nakaseomyces glabratus with non-functional Erg3 and Erg11—do collateral sensitivity and a unique mode of action make nitroxoline a viable UTI antifungal? [PDF]
mBioThe emergence of multidrug-resistant fungal pathogens from urinary tract infections (UTIs) poses a growing challenge in clinical settings. Here, we report a case of a complicated UTI caused by Nakaseomyces glabratus (Candida glabrata) that progressed to ...
Hans Carolus +14 more
doaj +2 more sources
Journal of Enzyme Inhibition and Medicinal Chemistry, 2020 Pancreatic cancer (PC) is one of the deadliest carcinomas and in most cases, which are diagnosed with locally advanced or metastatic disease, current therapeutic options are highly unsatisfactory.
Mattia Spanò +2 more
exaly +2 more sources
In Vitro and In Vivo Evaluation of Nitroxoline as an Effective Antimicrobial Alternative to Poultry Production [PDF]
AntibioticsBackground: Antimicrobial resistance is a major global challenge that is exacerbated by extensive antibiotic use in livestock farming. Identifying effective alternatives to widely used human antibiotics in animal production is vital to safeguard vital ...
Yuqing Zhou +18 more
doaj +2 more sources
Nitroxoline as an antimicrobial synergist reverses colistin resistance in multidrug-resistant Escherichia coli [PDF]
iScienceSummary: Colistin is a crucial drug for treating multidrug-resistant (MDR) Escherichia coli infections. The emergence and bacterial transmission of the colistin-resistant gene mcr-1 have substantially diminished its therapeutic efficacy.
Hao Wang +13 more
doaj +2 more sources
Nitroxoline mitigates hepatic steatosis by enhancing cholesterol efflux and promoting bile acid synthesis through LRH-1 signaling [PDF]
Lipids in Health and DiseaseBackground Metabolic associated fatty liver disease (MAFLD) has emerged as the most common chronic liver disease worldwide. However, effective pharmacological treatments remain limited.
Wen-Cheng Liu +7 more
doaj +2 more sources
Novel nitroxoline derivative combating resistant bacterial infections through outer membrane disruption and competitive NDM-1 inhibition [PDF]
Emerging Microbes and InfectionsNew Delhi metallo-β-lactamase-1 (NDM-1) has rapidly disseminated worldwide, leading to multidrug resistance and worse clinical prognosis. Designing and developing effective NDM-1 inhibitors is a critical and urgent challenge.
Peng He +10 more
doaj +2 more sources