Results 31 to 40 of about 645 (152)

Activity of the old antimicrobial nitroxoline against Mycobacterium abscessus complex isolates

Journal of Global Antimicrobial Resistance, 2023
: Objectives: The old antimicrobial nitroxoline is approved to treat urinary tract infection (UTI) and is currently rediscovered for treatment of drug resistant pathogens.
Ada Marie Hoffmann, Martina Wolke, Jan Rybniker, Georg Plum, Frieder Fuchs   +4 more
doaj   +1 more source

Successful Treatment of Balamuthia mandrillaris Granulomatous Amebic Encephalitis with Nitroxoline

Emerging Infectious Diseases, 2023
A patient in California, USA, with rare and usually fatal Balamuthia mandrillaris granulomatous amebic encephalitis survived after receiving treatment with a regimen that included the repurposed drug nitroxoline.
Natasha Spottiswoode, Douglas Pet, Annie Kim, Katherine Gruenberg, Maulik Shah, Amrutha Ramachandran, Matthew T. Laurie, Maham Zia, Camille Fouassier, Christine L. Boutros, Rufei Lu, Yueyuan Zhang, Venice Servellita, Andrew Bollen, Charles Y. Chiu, Michael R. Wilson, Liza Valdivia, Joseph L. DeRisi   +17 more
doaj   +1 more source

Review of the pharmacokinetic properties of nitrofurantoin and nitroxoline [PDF]

Journal of Antimicrobial Chemotherapy, 2018
Nitrofurantoin and nitroxoline are oral antibiotics for the treatment or prophylaxis of acute urinary tract infections. New interest in both these drugs is increasing because of the emergence of resistance to other antibiotics, but knowledge of their pharmacokinetics (PK) is lacking since they were developed before the advent of standardized research ...
Wijma RA, Huttner A, Koch BCP, Mouton JW, Muller AE   +4 more
openaire   +4 more sources

Whole genome sequencing analysis demonstrates therapy‐induced echinocandin resistance in Candida auris isolates

Mycoses, Volume 66, Issue 12, Page 1079-1086, December 2023., 2023
Abstract Candida auris is an emerging, multidrug‐resistant yeast, causing outbreaks in healthcare facilities. Echinocandins are the antifungal drugs of choice to treat candidiasis, as they cause few side effects and resistance is rarely found. Previously, immunocompromised patients from Kuwait with C.
Bram Spruijtenburg, Suhail Ahmad, Mohammad Asadzadeh, Wadha Alfouzan, Inaam Al‐Obaid, Eiman Mokaddas, Eelco F. J. Meijer, Jacques F. Meis, Theun de Groot   +8 more
wiley   +1 more source

Expert recommendations for prevention and management of Candida auris transmission

Mycoses, Volume 65, Issue 6, Page 590-598, June 2022., 2022
Abstract Candida auris was first described as a yeast pathogen in 2009. Since then, the species has emerged worldwide. In contrast to most other Candida spp., C. auris frequently exhibits multi‐drug resistance and is readily transmitted in hospital settings. While most detections so far are from colonised patients, C.
Alexander Maximilian Aldejohann, Miriam Wiese‐Posselt, Petra Gastmeier, Oliver Kurzai   +3 more
wiley   +1 more source

Targeting TRIM Proteins: A Quest towards Drugging an Emerging Protein Class

ChemBioChem, Volume 22, Issue 12, Page 2011-2031, June 15, 2021., 2021
It can be hard to get TRIM: TRIM proteins, the largest subfamily of single polypeptide RING E3 ligases, are currently gaining attention as targets for drug development. However, developing effective targeting options for TRIMs is challenged by their multidomain scaffolding nature correlating with multifunctional biological roles.
Francesca D'Amico, Rishov Mukhopadhyay, Huib Ovaa, Monique P. C. Mulder   +3 more
wiley   +1 more source

Au–Ag Bimetallic Catalysis: 3‐Alkynyl Benzofurans from Phenols via Tandem C−H Alkynylation/Oxy‐Alkynylation

Angewandte Chemie International Edition, Volume 60, Issue 19, Page 10637-10642, May 3, 2021., 2021
A mild and general synthesis of 3‐alkynylbenzofurans from readily available phenols by Au–Ag bimetallic catalysis has been developed. Importantly, this also advances our mechanistic understanding of the “silver effect” in gold redox chemistry. Abstract The development of new methodologies enabling a facile access to valuable heterocyclic frameworks ...
Long Hu, Martin C. Dietl, Chunyu Han, Matthias Rudolph, Frank Rominger, A. Stephen K. Hashmi   +5 more
wiley   +1 more source

INTERACTION OF PECTIN WITH THE ANTIBACTERIAL DRUG NITROXOLINE

chemistry of plant raw material, 2023
The process of macromolecular complexation of natural polymer pectin with nitroxoline, which has antibacterial activity, was studied in order to increase the solubility of the drug and, consequently, its therapeutic efficiency. By potentiometric titration it has been shown that in dilute aqueous solutions in a wide range of slightly acidic, neutral ...
Alla Mikhaylovna Khvan, Askar Sheralievich Abdurazakov   +1 more
openaire   +2 more sources

Raoultella terrigena: Current state of knowledge, after two recently identified clinical cases in Eastern Europe

Clinical Case Reports, Volume 9, Issue 5, May 2021., 2021
Raoultella terrigena is a rarely found opportunistic pathogen that can cause healthcare‐associated infections with high mortality. It is important to differentiate it from Klebsiella species. Abstract Raoultella terrigena is a rarely found opportunistic pathogen that can cause healthcare‐associated infections with high mortality.
Nadiia Lekhniuk, Ulbolgan Fesenko, Yaroslav Pidhirnyi, Alicja Sękowska, Olena Korniychuk, Yulian Konechnyi   +5 more
wiley   +1 more source

Evaluation of Disulfiram Drug Combinations and Identification of Other More Effective Combinations against Stationary Phase Borrelia burgdorferi

Antibiotics, 2020
Lyme disease, caused by Borrelia burgdorferi, is the most common vector-borne disease in USA, and 10–20% of patients will develop persistent symptoms despite treatment (“post-treatment Lyme disease syndrome”). B.
Hector S. Alvarez-Manzo, Yumin Zhang, Wanliang Shi, Ying Zhang   +3 more
doaj   +1 more source