Results 171 to 180 of about 15,525 (208)

A human NK cell progenitor that originates in the thymus and generates KIR⁺NKG2A^- NK cells. [PDF]

Sci Adv
Reiß J, Ghosh S, Scheid M, Graafen L, Scherenschlich N, Weinhold S, Raba K, Paulusch S, De Dominico E, Pham TXU, Beyer M, Laws HJ, Niehues T, Borkhardt A, Uhrberg M, Bennstein SB.   +15 more
europepmc   +1 more source

Selective elimination of circulating effector CD8 T cells via LTβR blockade separates anti-CD137 efficacy from toxicity. [PDF]

Sci Adv
Shein SA, Korchagina AA, Wang LJ, Lai Z, Chen Y, Fisher JS, Ludewig B, Lancaster JN, Fu YX, Koroleva E, Tumanov AV.   +10 more
europepmc   +1 more source

Dynamics of NK cell subsets following autologous hematopoietic stem cell transplantation in adult oncologic patients. [PDF]

Front Immunol
Astarloa-Pando G, Sandá V, Amarilla-Irusta A, Lopez-Pardo A, San Juan I, Iturbe-Larrondo A, Pérez-Garay R, Pérez-Fernández S, Santos-Zorrozúa B, Manzanares-Martín B, Bernardo R, González C, Uranga A, Rey M, Alonso M, Amutio E, Mateos-Mazón JJ, García-Ruiz JC, Zenarruzabeitia O, Amo L, Borrego F.   +20 more
europepmc   +1 more source

Molecular Interactions Between NK Cells and Acute Leukemic Cells: KIR2DL5 Drastically Limits NK Cell Responses. [PDF]

J Clin Immunol
Ferron E, Jullien M, Braud M, David G, Fourgeux C, Bastien M, Salameh P, Willem C, Legrand N, Walencik A, Guillaume T, Peterlin P, Garnier A, Lebourgeois A, Gagne K, Poschmann J, Chevallier P, Retière C.   +17 more
europepmc   +1 more source

Alterations in peripheral blood NK cell subsets and function in patients with HBeAg-positive chronic hepatitis B during pregnancy. [PDF]

Front Cell Infect Microbiol
Shen X, Zhang X, Cao Y, Zhang L, Yuan H, Wang H, Zhou Y, Diao S, Qi X, Li F, Fan Q, Li S.   +11 more
europepmc   +1 more source

Structural basis for NKG2A/CD94 recognition of HLA-E [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 2008
The NKG2x/CD94 (x = A, C, E) natural killer-cell receptors perform an important role in immunosurveillance by binding to HLA-E complexes that exclusively present peptides derived from MHC class I leader sequences, thereby monitoring MHC class I expression.
Roland K Strong
exaly   +3 more sources

NKG2A genetic deletion promotes human primary NK cell anti-tumor responses better than an anti-NKG2A monoclonal antibody

Molecular Therapy
Natural killer (NK) cells eliminate infected or cancer cells via their cytotoxic capacity. NKG2A is an inhibitory receptor on NK cells and cancer cells often overexpress its ligand HLA-E to evade NK cell surveillance. Given the successes of immune checkpoint blockade in cancer therapy, NKG2A is an interesting novel target.
Ying Gong, Roel G J Klein Wolterink, Timo   +2 more
exaly   +3 more sources

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NKG2A blocks the anti-metastatic functions of natural killer cells

Cancer Cell, 2023
Pancreatic ductal adenocarcinoma (PDAC)-derived liver metastasis represents a major unmet medical need. Liu et al. show that circulating tumor cells (CTCs) from the hepatic portal vein (HPV), and not from primary or metastatic sites, are protected from natural killer (NK) cells through the NKG2A/HLA-E axis.
Florent, Carrette, Eric, Vivier
openaire   +2 more sources

NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines [PDF]

Cell, 2018
Tumor-infiltrating CD8 T cells were found to frequently express the inhibitory receptor NKG2A, particularly in immune-reactive environments and after therapeutic cancer vaccination. High-dimensional cluster analysis demonstrated that NKG2A marks a unique immune effector subset preferentially co-expressing the tissue-resident CD103 molecule, but not ...
Nadine van Montfoort, Linda Borst, Michael J Korrer   +2 more
exaly   +3 more sources