Results 121 to 130 of about 90,508 (248)

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

Cancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang, Changyi Fan, Shiheng Chen, Tianyue Lu, Yuanyuan Li, Feng Du, Shanshan Wang   +6 more
wiley   +1 more source

An NLR paralog Pit2 generated from tandem duplication of Pit1 fine-tunes Pit1 localization and function

Nature Communications
NLR family proteins act as intracellular receptors. Gene duplication amplifies the number of NLR genes, and subsequent mutations occasionally provide modifications to the second gene that benefits immunity.
Yuying Li, Qiong Wang, Huimin Jia, Kazuya Ishikawa, Ken-ichi Kosami, Takahiro Ueba, Atsumi Tsujimoto, Miki Yamanaka, Yasuyuki Yabumoto, Daisuke Miki, Eriko Sasaki, Yoichiro Fukao, Masayuki Fujiwara, Takako Kaneko-Kawano, Li Tan, Chojiro Kojima, Rod A. Wing, Alfino Sebastian, Hideki Nishimura, Fumi Fukada, Qingfeng Niu, Motoki Shimizu, Kentaro Yoshida, Ryohei Terauchi, Ko Shimamoto, Yoji Kawano   +25 more
doaj   +1 more source

Correlation of neutrophil/lymphocyte, monocyte/lymphocyte, and CRP/ALB ratios with the extent of coronary artery lesions and their predictive value

Frontiers in Cardiovascular Medicine
ObjectiveThe aim of this paper was to investigate the correlation between neutrophil/lymphocyte (NLR), monocyte/lymphocyte (MLR), and CRP/ALB ratios with the degree of coronary artery disease and their predictive value.MethodsThis study retrospectively ...
Mingming Zhao, Jixian Rao, Shan Zhang, Zengfeng Su   +3 more
doaj   +1 more source

The changes of NLRs family members in the brain of AD mouse model and AD patients

Frontiers in Immunology
IntroductionAlzheimer’s disease (AD), a prevalent neurodegenerative disease, is primarily characterized by progressive neuron loss and memory impairment. NOD-like receptors (NLRs) are crucial for immune regulation and maintaining cellular homeostasis. Recently, NLRs have been identified as important contributors to neuroinflammation, thus presenting a ...
Zehan Li, Yanling He, Yanling He, Jingdan Zhang, Jing Yang, Jinbo Cheng, Jinbo Cheng, Jinbo Cheng, Xuewu Zhang   +8 more
openaire   +3 more sources

Long Non‐Coding RNA, Like NEAT1 and MALAT1, in Asthma: Mechanisms and Therapeutic Potential

Clinical &Experimental Allergy, EarlyView.
Long non‐coding RNA, like NEAT1 and MALAT1, is emerging as a regulator of asthma‐related inflammation, airway remodelling, viral responses and cell death pathways, and are promising targets for future therapeutics. ABSTRACT Asthma affects millions worldwide. Long non‐coding RNA (lncRNA) are emerging as important factors in the pathophysiology of asthma
Ashlyn Poole, Ingrid Laing, Ryan Mead‐Hunter, Peter Le Souef, Guicheng Zhang   +4 more
wiley   +1 more source

Long noncoding RNA X-inactive specific transcript regulates NLR family pyrin domain containing 3/caspase-1-mediated pyroptosis in diabetic nephropathy. [PDF]

World J Diabetes, 2022
Xu J, Wang Q, Song YF, Xu XH, Zhu H, Chen PD, Ren YP.   +6 more
europepmc   +1 more source

Diagnostic Options in Graves' or Non‐Graves' Thyrotoxicosis: A Review for Clinical Practice

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Distinguishing Graves' disease (GD) from the other causes of thyrotoxicosis is essential for appropriate management. The clinical phenotype of GD has evolved over time and is currently more heterogenous and milder than in the past. Consequently, the differential diagnosis of thyrotoxicosis is often challenging.
Lorenzo Scappaticcio, Pierpaolo Trimboli, Paola Caruso, Chiara Porcellini, Daniela Forestiere, Maria Ida Maiorino, Katherine Esposito, Giuseppe Bellastella   +7 more
wiley   +1 more source

Herpes Simplex Virus 1 Induces Microglia Gasdermin D-Dependent Pyroptosis Through Activating the NLR Family Pyrin Domain Containing 3 Inflammasome. [PDF]

Front Microbiol, 2022
Hu X, Zeng Q, Xiao J, Qin S, Wang Y, Shan T, Hu D, Zhu Y, Liu K, Zheng K, Wang Y, Ren Z.   +11 more
europepmc   +1 more source

Reduced Circulating Regulatory T Cells in Autoimmune and Chronic Idiopathic Neutropenia of Childhood: An Observational Study of Clinical and Laboratory Associations

European Journal of Haematology, EarlyView.
ABSTRACT Objectives To investigate circulating regulatory T cells (Tregs) in children with autoimmune neutropenia (AIN) and chronic idiopathic neutropenia (CIN) and evaluate their associations with clinical and laboratory features of neutropenia. Methods Plasma and Peripheral Blood Mononuclear Cells (PBMCs) were collected from 69 participants.
Konstantina Toutoudaki, Elena E. Solomou, Marianna Tzanoudaki, Stavros Glentis, Panagiota Perari, Panagiota Davoulou, Eftichia Theodoropoulou, Polyxeni Delaporta, Eleni Stamou, Irene Mavroudi, Charalambos Pontikoglou, Helen Papadaki, Antonis Kattamis   +12 more
wiley   +1 more source

Circular RNA circ_0090231 promotes atherosclerosis in vitro by enhancing NLR family pyrin domain containing 3-mediated pyroptosis of endothelial cells. [PDF]

Bioengineered, 2021
Ge Y, Liu W, Yin W, Wang X, Wang J, Zhu X, Xu S.   +6 more
europepmc   +1 more source