Results 121 to 130 of about 87,795 (274)

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Comparative analysis of machine learning based methods for the prediction of NLR protein

, 2022
In intestinal tissue repair and innate immunity, the nucleotide-binding domain leucine-rich repeat-containing (NLR) proteins play a fundamental role. The NLR protein family is a recent addition to the members of innate immunity effector molecules.
Gandotra, Ekta, Kumar, Narendra, Nadia, Nadia   +2 more
core  

The association between inflammatory markers in routine blood counts at 1 year and attention‐deficit/hyperactivity disorder (ADHD): A case–control study

Journal of Child Psychology and Psychiatry, EarlyView.
Background Attention‐deficit/hyperactivity disorder (ADHD) is a chronic neurodevelopmental disorder marked by persistent patterns of inattention, disorganization, hyperactivity, and impulsivity. Increasing evidence implicates immune‐inflammatory processes in its etiology, with observed associations between ADHD and infectious diseases, allergic ...
Eugene Merzon, Ariel Israel, Shelly Salminis‐Linzen, Eli Magen, Akim Geishin, Shlomo Vinker, Ilan Green, Avivit Golan‐Cohen, Shai Ashkenazi, Stephen V. Faraone, Abraham Weizman, Iris Manor   +11 more
wiley   +1 more source

Didymin, a natural flavonoid, relieves the progression of myocardial infarction via inhibiting the NLR family pyrin domain containing 3 inflammasome. [PDF]

Pharm Biol, 2022
Zhang Y, RuXian G.
europepmc   +1 more source

Analyses of novel molecular mechanism for regulating gene expression of anti-inflammatory NLR family member PYNOD

, 2015
細胞膜のTLR蛋白群および細胞質のNLR蛋白群は、病原微生物センサーである。申請者らは、自ら同定したNLR蛋白、PYNODが炎症抑制活性を持つことを見出した。さらに胃がんマウスモデルの病変部でPYNODの発現が、著明に上昇していることを発見した。炎症～発がん過程でPYNODの発現が上昇し、抗炎症作用の一端を担っているものと推測される。しかし他のマウス疾患モデルの腸炎や大腸がんではPYNODの発現増強が認められなかった。一方ヒト胃がん患者サンプルで、papillary type ...
今村, 龍, 71981, 10311680
core   +1 more source

Decoding stress resilience in soybean: Regulatory networks and precision breeding under climate change

Journal of Integrative Plant Biology, EarlyView.
This review covers recent progress in the understanding of stress‐responsive regulatory networks in soybean and highlights emerging genomic and breeding strategies. Integrating molecular insights and precision breeding will help to accelerate the development of climate‐resilient soybean cultivars.
Ali Shahzad, Monan Sun, Shuangkang Pei, Xiaoyu Liu, Yinhe Zhang, Keheng Xu, Hongtao Gao, Yonggang Zhou, Haiyan Li   +8 more
wiley   +1 more source

RefPlantNLR is a comprehensive collection of experimentally validated plant disease resistance proteins from the NLR family. [PDF]

PLoS Biol, 2021
Kourelis J, Sakai T, Adachi H, Kamoun S.
europepmc   +1 more source

Decoding MAPK cascades in plant immunity: Activation, regulation, integration, and pathogen manipulation

Journal of Integrative Plant Biology, EarlyView.
This review focuses on mitogen‐activated protein kinase (MAPK) activation and summarizes how plants regulate and integrate MAPK signaling in modulating plant immune responses. It also examines the effectors pathogens have evolved to manipulate MAPK activation and thereby inhibit plant immunity.
Guitao Zhong, Zhanchun Wang, Dingzhong Tang, Wei Wang   +3 more
wiley   +1 more source

Effects of early pregnancy on NOD-like receptor expression in the ovine endometrium

Frontiers in Veterinary Science
IntroductionNucleotide-binding domain (NOD)-like receptors (NLRs) are expressed in the endometrium, and involved in modulating the female innate immune responses.
Leying Zhang, Jiabao Cai, Xinxin Wang, Zhen Yang, Haiquan Ding, Ling Yang   +5 more
doaj   +1 more source

Genetic Susceptibility to Periodontitis

Journal of Periodontal Research, EarlyView.
Aim: The aim of this narrative review was to identify genes carrying risk alleles associated with an increased risk of periodontitis and to place them in a biological context. Methods: The literature was reviewed based on predefined criteria. Results: The identified genes largely fall into functions linking immune response with tissue repair. The genes
Gesa M. Richter, Arne S. Schaefer
wiley   +1 more source