Results 131 to 140 of about 4,243,571 (286)

White Adipose Tissue Browning and Cross Talk With Metabolic Diseases and Tumors: From Molecular Mechanisms to Clinical Translation

Med Research, EarlyView.
White adipose tissue undergoes browning under endogenous and exogenous stimuli, primarily regulated by core molecules such as PRDM16 and UCP1. It exhibits a double‐edged sword effect in metabolic diseases and tumors: while mitigating metabolic disease impacts and suppressing early‐stage tumors through nutritional competition, it may accelerate cachexia
Yingjiao Wang, Diyuan Zhang, Yuqin Zhou, Ling Qian, Yan Wang, Lei Peng, Min Zhao, Hao Tian, Zhenyu Wu, Aiqi Tang, Minghao Sun, Yi Zhang, Xiaowei Qi   +12 more
wiley   +1 more source

NOD2 Deficiency Protects against Cardiac Remodeling after Myocardial Infarction in Mice

Cellular Physiology and Biochemistry, 2013
Background/Aims: Although the pathogenesis of myocardial infarction (MI) is multifactorial, activation of innate immune system to induce inflammation has emerged as a key pathophysiological process in MI.
Xiang Li, Fengli Li, Yongli Chu, Xiaojie Wang, Hongyu Zhang, Yanyan Hu, Yan Zhang, Ziying Wang, Xinbing Wei, Wencheng Jian, Xiumei Zhang, Fan Yi   +11 more
doaj   +1 more source

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source

NRG1 functions downstream of EDS1 to regulate TIR-NLR-mediated plant immunity in Nicotiana benthamiana. [PDF]

, 2018
Effector-triggered immunity (ETI) in plants involves a large family of nucleotide-binding leucine-rich repeat (NLR) immune receptors, including Toll/IL-1 receptor-NLRs (TNLs) and coiled-coil NLRs (CNLs). Although various NLR immune receptors are known, a
Cho, Myeong-Je, Kim, Joonyoung Ryan, Pham, Julie, Qi, Tiancong, Schultink, Alex, Seo, Eunyoung, Seong, Kyungyong, Staskawicz, Brian J, Thomazella, Daniela PT   +8 more
core  

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Genome-wide identification of NOD-like receptor genes in redclaw crayfish (Cherax quadricarinatus) and their responses to DIV1 infection

Aquaculture Reports
Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs), classified as pattern recognition receptors (PRRs), play crucial roles in innate immune responses. However, research on this topic in crustaceans remains limited.
He Chang-Xi, Zheng Jian-Bo, Yucheng Zhang, Liu Shi-Li, Jiang Wen-Ping, Chi Mei-Li, Cheng Shun, Li Fei, Jia Yong-Yi   +8 more
doaj   +1 more source

Plasma Proteomics Analysis Identifying IGFBP2 as a Potential Diagnostic Biomarker for Laryngeal Squamous Cell Carcinoma

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Objective Currently, there are no blood biomarkers available for the early diagnosis of laryngeal squamous cell carcinoma (LSCC). The objective of this study was to search for potential plasma biomarkers for the diagnosis of LSCC. Methods Plasma samples were taken from patients with LSCC and healthy controls for proteomic analysis.
Shuang Teng, Ling‐Mei Qu, Jun‐Jie Liu, Yu‐Shan Li, Zi‐Qi Chen, Shuo Liu, Zhao‐Nan Xu, Meng Jin, Qiu‐Ying Li, Qin Wu, Hong‐Tian Yi, Xian‐Ji Shen, Bing‐Rui Yan, Ya‐Nan Sun   +13 more
wiley   +1 more source

Negative spatial regulation of the lineage specific CyIIIa actin gene in the sea urchin embryo [PDF]

, 1990
The CyIIIa·CAT fusion gene was injected into Strongylocentrotus purpuratus eggs, together with excess ligated competitor sequences representing subregions of the CyIIIa regulatory domain.
Britten, Roy J., Davidson, Eric H., Franks, Roberta R., Hough-Evans, Barbara R., Zeller, Robert W.   +4 more
core  

Spitzer-IRS high resolution spectroscopic survey of the 12 micron Seyfert galaxies: II. Results for the Complete Dataset

, 2009
We present the Spitzer 10-37um IRS high resolution (R~600) spectroscopic survey of the Seyfert galaxies of the 12 micron Galaxy Sample. The new spectra of 61 galaxies, with those already published, gives us a total of 91 12micron Seyfert galaxies ...
Antonucci, Armus, Bernard-Salas, Bird, Buchanan, Cardamone, Coziol, Dale, Dasyra, de Grijp, Deo, Dudik, Dudik, Durret, Genzel, Giovanni Fazio, Gorjian, Greene, Higdon, Houck, Hunt, Kollatschny, Krongold, Levenson, Luigi Spinoglio, Lutz, Malizia, Malkan, Matthew A. Malkan, Meléndez, Meléndez, Moran, Nelson, Osterbrock, Pence, Schulz, Shu, Silvia Tommasin, Spinoglio, Storchi-Bergmann, Terashima, Thornley, Tommasin, Tran, Tran, Veilleux, Weedman, Werner, Wu, Zhang   +49 more
core   +1 more source

Russian wheat aphid: a model for genomic plasticity and a challenge to breeders

Insect Science, EarlyView.
Invasive foundress finds suitable habitat and reproduces through pathogenesis. Wingless females produce life offspring quickly, which leads to high population densities. High population densities result in competition, which may induce epigenetic changes and wing development for dispersal.
Astrid Jankielsohn, Vicky L. Tolmay, Marlon‐Schylor Luke le Roux, Lintle Mohase, Mpho S. Mafa, Vittorio F. Nicolis, Eduard Venter, Nicolaas Francois Visser Burger, Anna‐Maria Botha   +8 more
wiley   +1 more source