Results 111 to 120 of about 4,243,571 (286)

All in the Family: The First Whole-Genome Survey of NLR Genes [PDF]

The Plant Cell, 2019
When The Plant Cell sent an invitation for me to write about an article that had a significant impact on my research, two articles came to mind immediately. One relates to our earlier work on flowering: the 2001 article by Lilac Pnueli and colleagues ([Pnueli et al., 2001][1]), which identified ...
openaire   +3 more sources

Vorinostat Potentiates Chemoimmunotherapy in Immune‐Enriched Pancreatic Cancer

Advanced Science, EarlyView.
Immune‐enriched pancreatic cancer does not confer a significant survival advantage. SAHA sensitizes these “hot” tumors to chemoimmunotherapy by disrupting a FASN/PARP9‐driven “metabolic trap” and enhancing CD8+ T cell function. A CD8high/FASNhigh/PARP9high signature identifies patients who are most likely to benefit from the “gemcitabine‐nivolumab‐SAHA”
Chen Chen, Dingru Li, Yingna Liao, Zehua Wang, Chunbin Zhu, Zifeng Zhang, Liquan Jin, Yueyue Chen, Jiaoshun Chen, Junyi Xu, Miaoyan Wei, Rong Tang, Xianjun Yu, Si Shi   +13 more
wiley   +1 more source

Alcohol-Induced Liver Injury Is Modulated by Nlrp3 and Nlrc4 Inflammasomes in Mice

Mediators of Inflammation, 2013
Alcoholic liver disease (ALD) is characterized by increased hepatic lipid accumulation (steatosis) and inflammation with increased expression of proinflammatory cytokines.
David A. DeSantis, Chih-wei Ko, Yang Liu, Xiuli Liu, Amy G. Hise, Gabriel Nunez, Colleen M. Croniger   +6 more
doaj   +1 more source

Brain and Liver Dual‐Targeting Oridonin Nanoparticles to Enhance Aβ Clearance for Alzheimer's Disease Therapy

Advanced Science, EarlyView.
We developed a nanoparticle named OAF, which simultaneously targeted to both the brain and liver via the transferrin receptor 1 (TfR1) receptor, promoting lipoprotein receptor‐related protein 1 (LRP1) expression to enhance amyloid‐beta (Aβ) clearance. In AD mice model, OAF significantly reduced Aβ deposition and cognitive impairment, while a mitigating
Wenshuai Gong, Wenting Hui, Sai Qiao, Qifeng Ji, Miao Liu, Bangle Zhang, Daozhou Liu, Yumei Wu, Siyuan Zhou   +8 more
wiley   +1 more source

NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens [PDF]

, 2012
Members of the intracellular nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family contribute to immune responses through activation of nuclear factor-kappa B (NF-kappa B), type I interferon and inflammasome signalling(1).
C van Ooij, DA Portnoy, E Elinav, E Scallan, EM Creagh, GY Chen, J Henao-Mejia, JM Grenier, John Bertin, John R. Lukens, K Hybiske, K Meixenberger, KS Kobayashi, L Franchi, M Lara-Tejero, MH Zaki, MM Stevenson, Mohamed Lamkanfi, MR Waterfield, NV Serbina, P Broz, Paras K. Anand, Peter Vogel, PK Anand, R. K. Subbarao Malireddi, S Normand, SC Corr, SE Girardin, TD Kanneganti, TD Kanneganti, Thirumala-Devi Kanneganti, V Pétrilli   +31 more
core   +1 more source

Advances in Gastric Cancer Research: Insights Into Carcinogenesis, the Tumor Microenvironment, Metastasis, and Factors Influencing Prognosis

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background The Department of Gastroenterological Surgery at Kumamoto University has maintained a commitment to integrating cutting‐edge clinical practice with fundamental research, particularly concerning malignant diseases of the digestive tract.
Hideo Baba, Takatsugu Ishimoto, Yoshifumi Baba, Hiromitsu Hayashi, Masaaki Iwatsuki   +4 more
wiley   +1 more source

The Role of NOD-like Receptors in Recognition of Pathogen-associated Molecular Patterns of Infectious Pathogens and in Development of Inflammation. Part 4. NLR Family Proteins are Involved in the Regulation of Process of Inflammation and Immune Respo

Zdorovʹe Rebenka, 2013
The survey described mechanisms for participation of NLR family proteins in the regulation of process of inflammation and immune response.
A.Ye. Abaturov, A.P. Volosovets, Ye.I. Yulish   +2 more
doaj   +1 more source

Modulation of plant autophagy during pathogen attack [PDF]

, 2017
In plants, the highly conserved catabolic process of autophagy has long been known as a means of maintaining cellular homeostasis and coping with abiotic stress conditions. Accumulating evidence has linked autophagy to immunity against invading pathogens,
Bozkurt, Tolga O., Duggan, Cian, Leary, Alexandre Y, Pandey, Pooja, Salguero Linares, Jose, Sanguankiattichai, Nattapong, Savage, Zachary D, Segretin, Maria Eugenia, Tumtas, Yasin, Yow, Rui Jin   +9 more
core   +1 more source

Pathogenic PF4/Polyanion ELISA‐Negative Antibodies in HIT

American Journal of Hematology, EarlyView.
ABSTRACT Background Platelet factor 4‐polyanion enzyme‐linked immunosorbent assays (ELISAs) are considered highly sensitive for diagnosing heparin‐induced thrombocytopenia (HIT), such that current practice guidelines recommend use of ELISA‐negative results to exclude HIT.
Adam J. Kanack, Noah P. Splinter, Emily E. Mauch, Leben Tefera, Morayma Reyes Gil, Sakshi Jasra, Andrew Goodwin, Kristi J. Smock, Hadiyah Ahmad, Aneel Ashrani, Nathaniel L. Robinson, Ana I. Casanegra, Curtis G. Jones, Shannon M. Pechauer, Erin Yttre, Richard H. Aster, Mindy C. Kohlhagen, Rachel R. Leger, Gretchen Johns, David L. Murray, Lu Zhou, Demin Wang, Renren Wen, Dong Chen, Rajiv K. Pruthi, Anand Padmanabhan   +25 more
wiley   +1 more source

Dusty, Radiation Pressure Dominated Photoionization. II. Multi-Wavelength Emission Line Diagnostics for Narrow Line Regions

, 2004
Seyfert narrow line region (NLR) emission line ratios are remarkably uniform, displaying only ~0.5 dex variation between galaxies, and even less within an individual object.
Binette L., Binette L., Brent A. Groves, Komossa S., Michael A. Dopita, Ralph S. Sutherland, Villar-Martin M.   +6 more
core   +2 more sources