The NLR family controls and interacts with specific CARDs.
CARD domain family control by NLR receptors included functional interaction between CARD11 and NLRP7.
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A complex NLR signalling network mediates immunity to diverse plant pathogens [PDF]
, 2016 Both plants and animals rely on nucleotide-binding domain leucine-rich repeat-containing (NLR) proteins to respond to invading pathogens and activate immune responses.
Wu, Chih-Hang
core
Molecular Oral Microbiology, EarlyView.Abstract Infection is a known cause of abdominal aortic aneurysm (AAA), and matrix metalloproteases‐2 (MMP‐2) secreted by vascular smooth muscle cells (SMCs) plays a key role in the structural disruption of the middle layer of the arteries during AAA progression.
Yi‐Wen Lin +6 more
wiley +1 more source
The changes of NLRs family members in the brain of AD mouse model and AD patients
Frontiers in ImmunologyIntroductionAlzheimer’s disease (AD), a prevalent neurodegenerative disease, is primarily characterized by progressive neuron loss and memory impairment. NOD-like receptors (NLRs) are crucial for immune regulation and maintaining cellular homeostasis. Recently, NLRs have been identified as important contributors to neuroinflammation, thus presenting a ...
Zehan Li +8 more
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Unfolding Plant Defence: Endoplasmic Reticulum Stress Signalling at the Plant‐Pathogen Interface
Plant Biotechnology Journal, EarlyView.ABSTRACT The endoplasmic reticulum (ER) stress response, a conserved proteostasis network, has emerged as a central hub that reprograms plant immunity during pathogen attack. This review synthesises how plants harness ER‐stress signalling to mount multilayered defences and how pathogens have evolved counterstrategies to subvert these pathways.
Zhe Meng +8 more
wiley +1 more source
AR-A014418, a glycogen synthase kinase-3β inhibitor, mitigates lipopolysaccharide-induced inflammation in rat dental pulp stem cells via NLR family pyrin domain containing 3 inflammasome impairment. [PDF]
J Dent Sci, 2023 Xie H, Lin Y, Fang F.
europepmc +1 more source
Structure and evolutionary history of a large family of NLR proteins in the zebrafish
Multicellular eukaryotes have evolved a range of mechanisms for immune recognition. A widespread family involved in innate immunity are the NACHT-domain and leucine-rich-repeat-containing (NLR) proteins.
Laird, Gavin K. +8 more
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PlantRG: A Comprehensive and User‐Friendly Database for Plant Resistance Gene Analogs (RGAs)
Plant Biotechnology Journal, EarlyView.ABSTRACT Resistance genes are critical for plant defence against biotic stresses, and building a comprehensive, integrated data resource platform for these genes holds great significance for plant research and agriculture. Here, we developed PlantRG (http://plantrg.bio2db.com), a user‐friendly plant resistance gene database, which is built on 2 163 397
Jinghua He +9 more
wiley +1 more source
Herpes Simplex Virus 1 Induces Microglia Gasdermin D-Dependent Pyroptosis Through Activating the NLR Family Pyrin Domain Containing 3 Inflammasome. [PDF]
Front Microbiol, 2022 Hu X +11 more
europepmc +1 more source
No Cost of Resistance in Wheat Gene Stack Lines Containing 10 Stem Rust Resistance Transgenes
Plant Biotechnology Journal, EarlyView.ABSTRACT Genetic resistance is the most economical and sustainable approach for crop protection, however, it is regularly overcome by pathogen virulence evolution. Polygenic resistance has greater durability, but unlinked genes are laborious to maintain in breeding programs.
Ming Luo +16 more
wiley +1 more source