Results 1 to 10 of about 98,851 (337)

A plant NLR receptor employs ABA central regulator PP2C-SnRK2 to activate antiviral immunity [PDF]

Nature Communications
Defence against pathogens relies on intracellular nucleotide-binding, leucine-rich repeat immune receptors (NLRs) in plants. Hormone signaling including abscisic acid (ABA) pathways are activated by NLRs and play pivotal roles in defence against ...
Shen Huang, Chunli Wang, Zixuan Ding, Yaqian Zhao, Jing Dai, Jia Li, Haining Huang, Tongkai Wang, Min Zhu, Mingfeng Feng, Yinghua Ji, Zhongkai Zhang, Xiaorong Tao   +12 more
doaj   +4 more sources

Evaluation of Nod-like receptor (NLR) effector domain interactions. [PDF]

PLoS ONE, 2009
Members of the Nod-like receptor (NLR) family recognize intracellular pathogens and recruit a variety of effector molecules, including pro-caspases and kinases, which in turn are implicated in cytokine processing and NF-kappaB activation.In order to ...
Roland N Wagner, Martina Proell, Thomas A Kufer, Robert Schwarzenbacher   +3 more
doaj   +4 more sources

Baseline neutrophil-lymphocyte ratio (NLR) predicts toxicity and survival in HR+/HER-2 breast cancer patients treated with CDK4/6 inhibitors [PDF]

Breast
The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that has been associated with prognosis in various malignancies. Its role in predicting toxicity and survival in patients with hormone receptor-positive, human epidermal growth
Omar Badran, Ali Darawshe, Sireen Sharif, Samih Yosef, Gil Bar-Sela   +4 more
doaj   +2 more sources

A plant NLR receptor activates auxin signaling through Aux/IAAs-ARF19 and YUC8-TIR1/AFBs to promote callose-mediated antiviral defense. [PDF]

Sci Adv
Yang T, Zhao R, Mei R, Cui H, Ding Z, Wen Y, Wu Q, Chen Z, Huang S, Wang C, Hong L, Zuo W, Zhang Z, Zhu M, Yang L, Zhang Z, Dong S, Xu Y, Tao X.   +18 more
europepmc   +2 more sources

Genome-wide identification and functional characterization of NOD-like receptors (NLRs) in snakehead (Channa argus)

Comparative Immunology Reports
NLR (NOD-like receptor) is a pattern recognition receptors (PRRs) and is crucial in the innate immune response. It identifies pathogen-associated molecular patterns (PAMPs) and modulates associated immune pathways.
Xiaochen Zhu, Beibei Wang, Lu Zhang, Xiaoyan Zhang, Chao Li   +4 more
doaj   +2 more sources

Genome-wide identification and analysis of the NLR gene family in Medicago ruthenica

Frontiers in Genetics, 2023
Medicago ruthenica, important forage in the legume family, possesses high nutritional value and carries abundant tolerance genes. This study used whole-genome data of M.
Chunyan Tong, Chunyan Tong, Yutong Zhang, Yutong Zhang, Fengling Shi, Fengling Shi   +5 more
doaj   +1 more source

Study to evaluate the relationship between receptor expression and clinical parameters in subjects with glioblastoma

Biomedical and Biotechnology Research Journal, 2023
Background: The most frequent and most aggressive primary brain tumor, glioblastoma (GBM) has an extremely poor prognosis. Several studies have shown the involvement of sex hormonal receptors and growth factor receptors in the onset of GBM.
K Ashwini, Jayaprakash Shetty, Kishan Prasad, Shilpa S Shetty, Ananthan Raghotham, Vijith Shetty, Praveen Kumar Shetty, N Suchetha Kumari   +7 more
doaj   +1 more source

A Meta-Analysis Reveals Opposite Effects of Biotic and Abiotic Stresses on Transcript Levels of Arabidopsis Intracellular Immune Receptor Genes

Frontiers in Plant Science, 2021
Plant intracellular immune receptor NLR (nucleotide-binding leucine-rich repeat) proteins sense the presence of pathogens and trigger strong and robust immune responses.
Leiyun Yang, Zhixue Wang, Jian Hua
doaj   +1 more source

Persistent neutrophil to lymphocyte ratio >3 during treatment with enzalutamide and clinical outcome in patients with castration-resistant prostate cancer [PDF]

, 2016
The baseline value of neutrophil to lymphocyte ratio (NLR) has been found to be prognostic in patients with metastatic castration resistant prostate cancer (CRPC). We evaluated the impact of baseline NLR and its change in patients receiving enzalutamide.
Caffo, Orazio, Conteduca, Vincenza, Crabb, Simon J., De Giorgi, Ugo, Derosa, Lisa, Elliott, Tony, Fabbri, Paolo, Hanna, Catherine, Jones, Robert J., Joyce, Helen, Lolli, Cristian, Maines, Francesca, Massari, Francesco, Numico, Gianmauro, Scarpi, Emanuela, Zarif, Sunnya   +15 more
core   +6 more sources

Wheat Disease Resistance Genes and Their Diversification Through Integrated Domain Fusions

Frontiers in Genetics, 2020
Plants are in a constant evolutionary arms race with their pathogens. At the molecular level, the plant nucleotide-binding leucine-rich repeat receptors (NLRs) family has coevolved with rapidly evolving pathogen effectors.
Ethan J. Andersen, Madhav P. Nepal, Jordan M. Purintun, Dillon Nelson, Glykeria Mermigka, Panagiotis F. Sarris, Panagiotis F. Sarris, Panagiotis F. Sarris   +7 more
doaj   +1 more source