Results 41 to 50 of about 82,639 (162)

Protein-protein interactions in the RPS4/RRS1 immune receptor complex.

PLoS Pathogens, 2017
Plant NLR (Nucleotide-binding domain and Leucine-rich Repeat) immune receptor proteins are encoded by Resistance (R) genes and confer specific resistance to pathogen races that carry the corresponding recognized effectors.
Sung Un Huh, Volkan Cevik, Pingtao Ding, Zane Duxbury, Yan Ma, Laurence Tomlinson, Panagiotis F Sarris, Jonathan D G Jones   +7 more
doaj   +1 more source

An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis

Nature Communications, 2019
CC and TIR-domain type NLR receptors trigger plant immunity in response to pathogen effectors. Here, Bhandari et al. show that the EP-domain surface of EDS1 heterodimers signals downstream of both receptor types and ensures a rapid transcriptional ...
Deepak D. Bhandari, Dmitry Lapin, Barbara Kracher, Patrick von Born, Jaqueline Bautor, Karsten Niefind, Jane E. Parker   +6 more
doaj   +1 more source

The correlation of the neutrophil–lymphocyte ratio to clinical and imaging parameters in patients with thyroid eye disease

Endocrine Connections, 2022
Thyroid eye disease (TED) is the major extrathyroidal manifesta tion of Graves’ disease (GD). Treatment choice is based on clinical activity and severi ty of TED, as evaluated with clinical activity score (CAS) and magnetic resonance (MR) imagi ng.
Xiaowen Zhang, Chen Han, Hongwei Wang, Xinghong Sun, Xin Dou, Xueying He, Di Wu, Shanmei Shen, Dalong Zhu, Xinlin Zhang, Yan Bi   +10 more
doaj   +1 more source

Two unequally redundant "helper" immune receptor families mediate Arabidopsis thaliana intracellular "sensor" immune receptor functions.

PLoS Biology, 2020
Plant nucleotide-binding (NB) leucine-rich repeat (LRR) receptor (NLR) proteins function as intracellular immune receptors that perceive the presence of pathogen-derived virulence proteins (effectors) to induce immune responses.
Svenja C Saile, Pierre Jacob, Baptiste Castel, Lance M Jubic, Isai Salas-Gonzáles, Marcel Bäcker, Jonathan D G Jones, Jeffery L Dangl, Farid El Kasmi   +8 more
doaj   +1 more source

Low neutrophil-to-lymphocyte ratio and pan-immune-inflammation-value predict nodal pathologic complete response in 1274 breast cancer patients treated with neoadjuvant chemotherapy: a multicenter analysis

Therapeutic Advances in Medical Oncology, 2023
Background: Systemic inflammatory markers draw great interest as potential blood-based prognostic factors in several oncological settings. Objectives: The aim of this study is to evaluate whether neutrophil-to-lymphocyte ratio (NLR) and pan-immune ...
Maria Luisa Gasparri, Sara Albasini, Marta Truffi, Karin Favilla, Barbara Tagliaferri, Francesca Piccotti, Daniela Bossi, Giulia Armatura, Arianna Calcinotto, Corrado Chiappa, Francesca Combi, Annalisa Curcio, Angelica Della Valle, Guglielmo Ferrari, Secondo Folli, Matteo Ghilli, Chiara Listorti, Stefano Mancini, Peter Marinello, Simone Mele, Anna Pertusati, Manuela Roncella, Lorenzo Rossi, Francesca Rovera, Silvia Segattini, Adele Sgarella, Daniela Tognali, Fabio Corsi   +27 more
doaj   +1 more source

Baseline neutrophil-lymphocyte ratio (NLR) predicts toxicity and survival in HR+/HER-2 breast cancer patients treated with CDK4/6 inhibitors

Breast
The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that has been associated with prognosis in various malignancies. Its role in predicting toxicity and survival in patients with hormone receptor-positive, human epidermal growth
Omar Badran, Ali Darawshe, Sireen Sharif, Samih Yosef, Gil Bar-Sela   +4 more
doaj   +1 more source

A genomic view of the NOD-like receptor family in teleost fish: identification of a novel NLR subfamily in zebrafish

BMC Evolutionary Biology, 2008
Background A large multigene family of NOD-like receptor (NLR) molecules have been described in mammals and implicated in immunity and apoptosis. Little information, however, exists concerning this gene family in non-mammalian taxa.
Winton James R, Purcell Maureen K, Laing Kerry J, Hansen John D   +3 more
doaj   +1 more source

The NLR-Annotator Tool Enables Annotation of the Intracellular Immune Receptor Repertoire [PDF]

Plant Physiology, 2020
Disease resistance genes encoding nucleotide-binding and leucine-rich repeat (NLR) intracellular immune receptor proteins detect pathogens by the presence of pathogen effectors. Plant genomes typically contain hundreds of NLR-encoding genes. The availability of the hexaploid wheat (Triticum aestivum) cultivar Chinese Spring reference genome allows a ...
Steuernagel, Burkhard, Witek, Kamil, Krattinger, Simon G, Ramirez-Gonzalez, Ricardo H, Schoonbeek, Henk-jan, Yu, Guotai, Baggs, Erin, Witek, Agnieszka I, Yadav, Inderjit, Krasileva, Ksenia V, Jones, Jonathan D G, Uauy, Cristobal, Keller, Beat, Ridout, Christopher J, Wulff, Brande B H   +14 more
openaire   +4 more sources

An atypical NLR protein modulates the NRC immune receptor network in Nicotiana benthamiana

PLoS Genetics, 2023
The NRC immune receptor network has evolved in asterid plants from a pair of linked genes into a genetically dispersed and phylogenetically structured network of sensor and helper NLR (nucleotide-binding domain and leucine-rich repeat-containing ...
Hiroaki Adachi, Toshiyuki Sakai, Adeline Harant, Hsuan Pai, Kodai Honda, AmirAli Toghani, Jules Claeys, Cian Duggan, Tolga O. Bozkurt, Chih-hang Wu, Sophien Kamoun   +10 more
doaj  

Structure of fish Toll-like receptors (TLR) and NOD-like receptors (NLR)

International Journal of Biological Macromolecules, 2020
Innate immunity driven by pattern recognition receptor (PRR) protects the host from invading pathogens. Aquatic animals like fish where the adaptive immunity is poorly developed majorly rely on their innate immunity modulated by PRRs like toll-like receptors (TLR) and NOD-like receptors (NLR).
openaire   +3 more sources