Results 61 to 70 of about 82,639 (162)

Recent advances in plant NLR structure, function, localization and signaling

Frontiers in Immunology, 2013
Nucleotide-binding domain leucine-rich repeat (NLR) proteins play a central role in the innate immune systems of plants and vertebrates. In plants, NLR proteins function as intracellular receptors that detect pathogen effector proteins directly, or ...
Dong eQi, Roger W Innes
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The helper NLR immune protein NRC3 mediates the hypersensitive cell death caused by the cell-surface receptor Cf-4.

PLoS Genetics, 2022
Cell surface pattern recognition receptors (PRRs) activate immune responses that can include the hypersensitive cell death. However, the pathways that link PRRs to the cell death response are poorly understood.
Jiorgos Kourelis, Mauricio P Contreras, Adeline Harant, Hsuan Pai, Daniel Lüdke, Hiroaki Adachi, Lida Derevnina, Chih-Hang Wu, Sophien Kamoun   +8 more
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Development of a predictive model utilizing the neutrophil to lymphocyte ratio to predict neoadjuvant chemotherapy efficacy in early breast cancer patients

Scientific Reports, 2021
Neutrophils and lymphocytes are key regulators of breast cancer (BC) development and progression. Neutrophil to lymphocyte ratio (NLR) values have been found to offer clear prognostic utility when evaluating BC patients.
Jiujun Zhu, Dechuang Jiao, Yajie Zhao, Xuhui Guo, Yue Yang, Hui Xiao, Zhenzhen Liu   +6 more
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Inhibitory effect of nintedanib on VEGF secretion in retinal pigment epithelial cells induced by exposure to a necrotic cell lysate.

PLoS ONE, 2019
Necrosis is a form of cell death that results in rupture of the plasma membrane and the release of cellular contents, and it can give rise to sterile inflammation in the retina and other tissues. The secretion of vascular endothelial growth factor (VEGF)
Makoto Hatano, Kazuhiro Tokuda, Yuka Kobayashi, Chiemi Yamashiro, Sho-Hei Uchi, Masaaki Kobayashi, Kazuhiro Kimura   +6 more
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Predictive efficacy of the preoperative neutrophil–lymphocyte ratio in lymph node metastasis of cN0 hormone receptor-positive breast cancer

Scientific Reports
Breast cancer, as the most common cancer, has surpassed lung cancer worldwide. The neutrophil-to-lymphocyte ratio (NLR) has been linked to the onset of cancer and its prognosis in recent studies.
Miao-Feng Wang, Jia-Rui Cai, Heng Xia, Xiu-feng Chu   +3 more
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Dissection of Two Complex Clusters of Resistance Genes in Lettuce (Lactuca sativa)

Molecular Plant-Microbe Interactions, 2015
Of the over 50 phenotypic resistance genes mapped in lettuce, 25 colocalize to three major resistance clusters (MRC) on chromosomes 1, 2, and 4. Similarly, the majority of candidate resistance genes encoding nucleotide binding-leucine rich repeat (NLR ...
Marilena Christopoulou, Leah K. McHale, Alex Kozik, Sebastian Reyes-Chin Wo, Tadeusz Wroblewski, Richard W. Michelmore   +5 more
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Innate immune receptors for cross-presentation: The expanding role of NLRs

Molecular Immunology, 2019
A critical role of pattern recognition receptors (PRRs) is to influence adaptive immune responses by regulating antigen presentation. Engagement of PRRs in dendritic cells (DCs) increases MHC class I antigen presentation and CD8+ T-cell activation by cross-presented peptides but the molecular mechanisms underlying these effects are not completely ...
Corridoni, D, Simmons, A
openaire   +3 more sources

Genome-wide identification and functional characterization of NOD-like receptors (NLRs) in snakehead (Channa argus)

Comparative Immunology Reports
NLR (NOD-like receptor) is a pattern recognition receptors (PRRs) and is crucial in the innate immune response. It identifies pathogen-associated molecular patterns (PAMPs) and modulates associated immune pathways.
Xiaochen Zhu, Beibei Wang, Lu Zhang, Xiaoyan Zhang, Chao Li   +4 more
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The soybean plasma membrane GmDR1 protein conferring broad-spectrum disease and pest resistance regulates several receptor kinases and NLR proteins

Scientific Reports
Overexpression of Glycine max disease resistant 1 (GmDR1) exhibits broad-spectrum resistance against Fusarium virguliforme, Heterodera glycines (soybean cyst nematode), Tetranychus urticae (Koch) (spider mites), and Aphis glycines Matsumura (soybean ...
Micheline N. Ngaki, Subodh K. Srivastava, Wang Feifei, Madan K. Bhattacharyya   +3 more
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The dynamic TaRACK1B-TaSGT1-TaHSP90 complex modulates NLR-protein-mediated antiviral immunity in wheat

Cell Reports
Summary: Nucleotide-binding leucine-rich repeat (NLR) proteins contribute widely to plant immunity by regulating defense mechanisms through the elicitation of a hypersensitive response (HR).
Haichao Hu, Tianye Zhang, Jinnan Wang, Jun Guo, Yaoyao Jiang, Qiansheng Liao, Lu Chen, Qisen Lu, Peng Liu, Kaili Zhong, Jiaqian Liu, Jianping Chen, Jian Yang   +12 more
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