Results 171 to 180 of about 131,202 (338)

Inflammation and Fibrosis duringChlamydia pneumoniaeInfection Is Regulated by IL-1 and the NLRP3/ASC Inflammasome [PDF]

, 2010
Xianbao He, Samrawit Mekasha, Nikolaos Mavrogiorgos, Katherine A. Fitzgerald, Egil Lien, Robin R. Ingalls   +5 more
openalex   +1 more source

Association of clonal haematopoiesis with heart failure incidence and outcomes: A systematic review and meta‐analysis

European Journal of Heart Failure, EarlyView.
Association of clonal haematopoiesis with heart failure incidence and outcomes: A systematic review and meta‐analysis. Clonal haematopoiesis and heart failure: a meta‐analysis. CH, clonal haematopoiesis; CI, confidence interval; HF, heart failure. [Correction added on 15 March 2025, after first online publication: The graphical image was corrected in ...
Paschalis Karakasis, Eleftheria Lefkou, Konstantinos Pamporis, Dimitrios Farmakis, Dimitrios Patoulias, Antonios P. Antoniadis, Stephane Heymans, Gerasimos Filippatos, Nikolaos Fragakis   +8 more
wiley   +1 more source

Initial description of the human NLRP3 promoter

, 2008
Justin P. Anderson, James L. Mueller, Amir Misaghi, S. Anderson, Mamata Sivagnanam, Richard D. Kolodner, Hal M. Hoffman   +6 more
openalex   +1 more source

Activation of the NLRP3 inflammasome by intracellular poly I:C [PDF]

, 2010
Jayant V. Rajan, Sarah Warren, Edward A. Miao, Alan Aderem   +3 more
openalex   +1 more source

Engineered Exosome‐Based Senolytic Therapy Alleviates Stroke by Targeting p21+CD86+ Microglia

Exploration, EarlyView.
We identified a harmful immune cell type, p21+CD86+ microglia, driving post‐stroke inflammation and developed a targeted exosome‐based therapy (Que@micro‐Exo) to eliminate these cells. This innovative treatment reduced inflammation, alleviated brain damage, and improved recovery in stroke models, offering a promising strategy for stroke and other ...
Jialei Yang, Shipo Wu, Miao He
wiley   +1 more source

Osteoblasts Express NLRP3, a Nucleotide-Binding Domain and Leucine-Rich Repeat Region Containing Receptor Implicated in Bacterially Induced Cell Death

, 2008
Samuel H McCall, Mahnaz Sahraei, Amy B Young, Charles S Worley, Joseph A. Duncan, Jenny Pan-Yun Ting, Ian Marriott   +6 more
openalex   +2 more sources

Immunomodulatory Nanozymes Eradicate Intracellular Infections and Rescue Immunoparalysis for Treating Multidrug‐Resistant Bacterial Sepsis

Exploration, EarlyView.
Immunomodulatory nanozymes enable in situ macrophages engineering and orchestrate systemic innate‐adaptive immune response to eradicate intracellular bacteria and rescue immunoparalysis for treating multidrug‐resistant bacterial sepsis. ABSTRACT Sepsis and their sequelae are the leading causes of death in intensive care units, with limited therapeutic ...
Xuancheng Du, Zhenzhen Dong, Yan Yan, Yuan Gong, Meili Yuan, Chengtai Ma, Lingqi Xu, Yuanyuan Qu, Minhan Qu, Peng Pan, Weifeng Li, Wenyan Hao, Yingyi Yang, Xiangdong Liu, Mingwen Zhao, Zhenjiang Bai, Jiang Huai Wang, Jian Wang, Yong‐Qiang Li, Huiting Zhou   +19 more
wiley   +1 more source

Alfalfa Flavonoids Mitigate Salmonella‐Induced Colitis via the Keap1‐Nrf2 and TLR4/NF‐κB/COX‐2 Pathways

Food Frontiers, EarlyView.
Alfalfa flavonoids (AF) protected against Salmonella‐induced colitis by reducing inflammation and oxidative stress. AF inhibited the TLR4/IκB/NF‐κB/COX‐2 pathway and NLRP3 inflammasome, lowering pro‐inflammatory cytokines, while activating Keap1‐Nrf2 to boost antioxidants (e.g., HO‐1, NQO1, SOD, GPx), decreasing ROS‐driven oxidative stress.
Xiaoli Qin, Yan Lu, Yawen Luo, Yafang Cui, Kai Zhao, Yang He, Muhammad Aziz ur Rahman, Shengnan Min, Wenfang Wang, Fuyu Yang, Binghai Cao, Huawei Su   +11 more
wiley   +1 more source

Role of Pyroptosis in Endometrial Cancer and Its Therapeutic Regulation

Journal of Inflammation Research
Abdullah Al Mamun,1,2 Peiwu Geng,1 Shuanghu Wang,1 Chuxiao Shao1 1Key Laboratory of Joint Diagnosis and Treatment of Chronic Liver Disease and Liver Cancer of Lishui, The Lishui Hospital of Wenzhou Medical University, The First Affiliated Hospital of ...
Al Mamun A, Geng P, Wang S, Shao C
doaj  

FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

Neural Regeneration Research
Alzheimer’s disease is characterized by deposition of amyloid-β, which forms extracellular neuritic plaques, and accumulation of hyperphosphorylated tau, which aggregates to form intraneuronal neurofibrillary tangles, in the brain. The NLRP3 inflammasome
Jing Yao, Yuan Li, Xi Liu, Wenping Liang, Yu Li, Liyong Wu, Zhe Wang, Weihong Song   +7 more
doaj   +1 more source