Results 181 to 190 of about 104,328 (314)

The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome

Disease Models & Mechanisms
Tara A. Gleeson, Christina Kaiser, Catherine B. Lawrence, David Brough, Stuart M. Allan, Jack P. Green   +5 more
doaj   +1 more source

AMPK-NLRP3 Inflammasome Crosstalk: Structural Insights, Molecular Mechanisms, and Therapeutic Implications for Inflammation and Neuroinflammation. [PDF]

Mol Neurobiol
Kodi T, Nandakumar K, Kishore A.
europepmc   +1 more source

NLRP3 Inflammasome Upregulates PD-L1 in Ovarian Cancer and Contributes to an Immunosuppressive Microenvironment

Wenjing Pan,1,* Zhaoyang Jia,1,* Jingtong Du,1,* Kexin Chang,2 Yiming Liu,2 Wei Liu,1 Xibo Zhao,3 Wenhua Tan1 1Department of Gynecology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, 150081, People’s ...
Pan W, Liu Y, Chang K, Tan W, Du J, Jia Z, Liu W, Zhao X   +7 more
core  

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

NLRP3 Inflammasome Inhibition After Pilocarpine-Induced Status Epilepticus Attenuates Chronic Inflammation in Epileptic Mice

Lei Wang,1,* Kai Wang,2,* Yuwen Chen,1 Xiaoyu Zhang,1,3 Wenhao Xu,1,3 Zhong Dong,1,3 Yu Wang1,3,4 1Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, 230000, People’s Republic of China ...
Zhang X, Dong Z, Chen Y, Wang Y, Xu W, Wang K, Wang L   +6 more
core  

Sustained‐Release Ulcer‐Protective Microarray Patch With Dihydrocapsaicin for Diabetic Wound Regeneration

Exploration, EarlyView.
Schematic illustration of the effect of microneedles incorporating cerium‐based MOF loading dihydrocapsaicin (MN‐MOF@DHC) to scavenge reactive oxygen species (ROS) generation, beanti‐inflammatory, inhibit the apoptosis of endothelial cells (ECs), promote angiogenesis, and accelerate diabetic wound healing. ABSTRACT Diabetic foot ulcers (DFUs) present a
Yuxu Wu, Kan Jiang, Xiao Wen, Chihao Jin, Kai Zhang, Jiakai Zhang, Jiale Jin, Jiaqian Wang, Huiyu Hu, Zonghan Xu, Xianzhu Zhang, Yihe Hu   +11 more
wiley   +1 more source

Progress in the Treatment of Ulcerative Colitis by Targeting NLRP3 Inflammasome. [PDF]

Drug Des Devel Ther
Chen J, Zhang E, Qian X, Shang X, Yu J, Luo J, Hao W.   +6 more
europepmc   +1 more source

NLRP3 Gene [PDF]

, 2020
openaire   +1 more source

Smart Nanodelivery Systems for Immunometabolic Modulation in Osteoarthritis

Exploration, EarlyView.
Smart nanodelivery systems deliver therapeutic payloads across the cartilage matrix to ensure their sustained accumulation within chondrocytes at sites of injury. By targeting specific molecular targets and signaling pathways, these platforms modulate the pathological synovium‐cartilage axis to restore immunometabolic homeostasis and drive tissue ...
Qirui Zhao, Zhewen Mi, Shuya Liu, Shijun Liang, Linjia Peng, Zixuan Gao, Jiaming Li, Xiaoqing Lu, Zhiguang Ren, Yongjie Wan, Shengsheng Cui, Longlong Lu, Xiaoyang Gao, Tao Wang, Hui Liang, Furong Tian, de la Fuente Jesus M, Chong Xiang, Luyi Sun, Lichen Xiang, Daxiang Cui   +20 more
wiley   +1 more source

Aging reprograms microglia toward an inflammasome-linked response to traumatic brain injury. [PDF]

J Clin Invest
Morganti JM, Bachstetter AD.
europepmc   +1 more source