Results 171 to 180 of about 104,328 (314)

Electroacupuncture Inhibits NLRP3-Mediated Microglial Pyroptosis to Ameliorate Chronic Neuropathic Pain in Rats

Wenyun Kui, Yanan Li, Zhen Gu, Lei Xie, Aiping Huang, Shuyi Kong, Lilong Song, Lingxing Li, Jun Yu, Chun-Chun Xue, Kaiqiang Wang Department of Pain, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese ...
Song L, Kui W, Xue CC, Li Y, Xie L, Gu Z, Kong S, Huang A, Yu J, Li L, Wang K   +10 more
core  

From Inflammatory Bowel Disease to Cancer: Gut Microbiota–Immune Microenvironment Crosstalk and Natural Product‐Based Therapeutic Opportunities

Cancer Nexus, EarlyView.
ABSTRACT Inflammatory bowel disease (IBD), primarily Crohn's disease and ulcerative colitis, is a chronic relapsing inflammatory disorder of the gastrointestinal tract and an important risk factor for IBD‐associated cancer. Increasing evidence suggests that gut microbiota dysbiosis, epithelial barrier dysfunction, and immune microenvironment remodeling
Xue Zhang, Chongchong Gao, Rui Jiang, Zijian Wu, Jian Bai   +4 more
wiley   +1 more source

[[alternative]]To investigate the role of NLRP3 inflammasome on contusive muscle injury in animal model

, 2020
[[abstract]]發炎體 (Inflammasome) 是一組複雜的炎症相關蛋白質家族，其參與調控免疫活化與炎症反應。挫傷為主要的運動傷害之一，由於發炎體在肌肉挫傷中扮演的角色仍未明且NLRP3 (NLR family pyrin domain containing 3) 發炎體在發炎體家族中極為重要，因此，本研究使用NLRP3 (Knockout, KO) 基因剔除鼠來探討發炎體在肌肉挫傷中之角色。試驗使用重物自由落體造成腓腸肌的肌肉挫傷 (Mass-drop injury, MDI ...
Chiu, Liang-Ju, 邱亮儒
core  

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

Spatial control of NLRP3 inflammasome assembly by membrane lipid composition. [PDF]

Commun Biol
Anand PK, Aljadeed NM.
europepmc   +1 more source

Effects of Nintedanib on the Lungs via NLRP3 in a Model of Lipopolysaccharide-induced Acute Lung Injury in Rats

Aim: To demonstrate the possible protective efficacy of nintedanib, a tyrosine kinase inhibitor with demonstrated antifibrotic and antitumor activity, in a model of acute lung injury (ALI), a severe lung disease, through NLR family pyrin domain ...
ÇADIRCI, Elif, Zekai HALICI, HALICI, Zekai, Elif ÇADIRCI, Erdem TOKTAY, Pelin AYDIN, Tanriverdiyeva, Gulchin, Gulchin TANRİVERDİYEVA, Aydin, Pelin, TOKTAY, Erdem   +9 more
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Stage-dependent role of NEK7 in the inactive-to-active conformational transition of NLRP3 monomer. [PDF]

PLoS Comput Biol
Peng J, Li W, Wang H, Chen X, Zhang M, Sun B.   +5 more
europepmc   +1 more source

Fingolimod Suppresses NLRP3 Inflammasome Activation and Alleviates Oxidative Stress in Traumatic Brain Injury-Induced Acute Lung Injury

Qi Shi,1,* Tingting Hu,2,* Lixia Xu,2,* Jiayuanyuan Fu,1 Yehong Fang,1 Yu Lan,1 Weijia Fan,2 Qiaoli Wu,2 Xiaoguang Tong,1– 3 Hua Yan1– 3 1Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin,
Xu L, Fang Y, Fan W, Hu T, Wu Q, Shi Q, Fu J, Tong X, Yan H, Lan Y   +9 more
core  

The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle

ESC Heart Failure, Volume 12, Issue 2, Page 1045-1058, April 2025.
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley   +1 more source