Results 311 to 320 of about 150,409 (337)

Table 1_MicroRNAs as regulators of NLRP3 inflammasome activation in herpes simplex virus type 2 infection.docx

Debashree Dass (21390476), Anwesha Banerjee (3564272), Ashwini More (10208658), Anupam Mukherjee (379902)   +3 more
openalex   +1 more source

Targeting the NLRP3 inflammasome in kidney disease: molecular mechanisms, pathogenic roles, and emerging small-molecule therapeutics. [PDF]

Front Immunol
Luo Y, Long M, Wu X, Zeng L.
europepmc   +1 more source

LARP7 protects against ischemic brain injury by modulating NLRP3 deacetylation to suppress neuronal pyroptosis. [PDF]

J Neuroinflammation
Tang H, Wen J, Yang Q, Wang L, Qin T, Ren Y, Zhao Y, Wu Y, Li C, Li J, He Y, Huang J, Zi W, Yang Q.   +13 more
europepmc   +1 more source

NLRP3-induced systemic inflammation controls the development of JAK2V617F mutant myeloproliferative neoplasms. [PDF]

Nat Commun
Koerber RM, Krollmann C, Cieslak K, Tregel E, Saenz ML, Brümmendorf TH, Koschmieder S, Griesshammer M, Gütgemann I, Baldauf CK, Fischer T, Brossart P, Kolbe CC, Latz E, Wolf D, Teichmann LL.   +15 more
europepmc   +1 more source

Radiation meets inflammation: NLRP3 inflammasome at the core of radiation-induced cardiac injury. [PDF]

J Transl Med
Boncompagni C, Giacovazzi S, Perrone M, Missiroli S, Righes G, Pinton P, Giorgi C.   +6 more
europepmc   +1 more source

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NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages

International Immunopharmacology, 2021
INF39 is a nontoxic, irreversible, acrylate-based NLRP3 inhibitor and a further optimization of ethyl 2-((2-chlorophenyl) hydroxyl) methyl) acrylate (INF4E). However, the detail mechanism and the direct target of its anti-inflammatory activity is not clear. Here, we show that INF39 is a specific inhibitor for NLRP3 inflammasome activation.
Yuhua Shi, Qian Lv, Mengjie Zheng, Hongxiang Sun, Fushan Shi   +4 more
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Ergolide covalently binds NLRP3 and inhibits NLRP3 inflammasome-mediated pyroptosis

International Immunopharmacology, 2023
NLR family pyrin domain-containing 3 (NLRP3)-mediated pyroptosis plays a key role in various acute and chronic inflammatory diseases. Targeted inhibition of NLRP3-mediated pyroptosis may be a potential therapeutic strategy for various inflammatory diseases.
Miao Ren, Jiahao Chen, Haowen Xu, Weifeng Li, Tingting Wang, Zhanghuan Chi, Yi Lin, Anqi Zhang, Gaozhi Chen, Xu Wang, Xiaoyu Sun, Guang Liang, Junlu Wang, Wu Luo   +13 more
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Ubiquitination of NLRP3 by gp78/Insig-1 restrains NLRP3 inflammasome activation

Cell Death & Differentiation, 2022
The NLRP3 (NOD-, LRR- and pyrin domain-containing protein 3) inflammasome plays a pivotal role in defending the host against infection as well as sterile inflammation. Activation of the NLRP3 inflammasome is critically regulated by a de-ubiquitination mechanism, but little is known about how ubiquitination restrains NLRP3 activity. Here, we showed that
Ting Xu, Weiwei Yu, Hui Fang, Zhen Wang, Zhexu Chi, Xingchen Guo, Danlu Jiang, Kailian Zhang, Sheng Chen, Mobai Li, Yuxian Guo, Jian Zhang, Dehang Yang, Qianzhou Yu, Di Wang, Xue Zhang   +15 more
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