Results 311 to 320 of about 135,752 (336)

β3‐Adrenoceptor Agonist Effects on the Urinary Bladder Beyond Detrusor Relaxation

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims β3‐Adrenoceptor agonists such as mirabegron or vibegron reach pharmacokinetic steady‐state within a few days. However, maximum improvements in symptoms of the overactive bladder syndrome are reached at time points later than 4 weeks, that is, detrusor smooth muscle relaxation cannot fully explain clinical effects.
Martin C. Michel, Ebru Arioglu‐Inan, Martin Hennenberg   +2 more
wiley   +1 more source

Impact of excessive hypercholesterolemia in pregnancy on the placentas of the male and female offspring. [PDF]

Sci Rep
de Oliveira AA, Stokes A, Quon A, Graton ME, Spaans F, Cooke CM, Davidge ST.   +6 more
europepmc   +1 more source

Mitochondrial transfer as a novel therapeutic approach in ischemic stroke treatment: Current challenges and future perspectives

Neuroprotection, EarlyView.
Cerebral ischemia is a serious neurological disease that mainly leads to pathological changes such as mitochondrial dysfunction, oxidative stress and iron death. Mitochondria play a key role in the regulation of cellular energy metabolism and oxidative stress, and their damage can lead to mitochondrial damage, reduced adenosine triphosphate production,
Shuchen Meng, Min Bai, Changsheng Ma, Bo Han, Mengyuan Duan, Liying Zhang, Jinfen Guo, Changku Shi, Ke Li, Maotao He   +9 more
wiley   +1 more source

Inflammasome Signaling in Cardiac Arrhythmias: Linking Inflammation, Fibrosis, and Electrical Remodeling. [PDF]

Int J Mol Sci
Karakasis P, Pamporis K, Theofilis P, Milaras N, Vlachakis PK, Grigoriou K, Patoulias D, Karamitsos T, Antoniadis AP, Fragakis N.   +9 more
europepmc   +1 more source

Role of astrocyte in neuroinflammation‐induced loss in neuroplasticity and subsequent onset of depression: A systematic review

Neuroprotection, EarlyView.
Mechanistic crosstalk between microglia and astrocytes in major depressive disorder. Abstract Major depressive disorder (MDD) is a complex psychiatric condition increasingly linked to chronic neuroinflammation, particularly in the context of aging, stress, and systemic comorbidities.
Gaurav Singhal, Saurabh Singhal, Bernhard T. Baune   +2 more
wiley   +1 more source

UCP2 inhibition exaggerates diabetic cardiomyopathy by facilitating the activation of NLRP3 and pyroptosis. [PDF]

Diabetol Metab Syndr
Zhang L, Ai C, Guo C, Li S, Niu J, Meng X, Zhang Z.   +6 more
europepmc   +1 more source

Altered Bacteria Abundance Is Associated With Outcomes in Head and Neck Squamous Cell Carcinoma

Otolaryngology–Head and Neck Surgery, Volume 173, Issue 2, Page 420-432, August 2025.
Abstract Objective To determine if microbiome differences exist in head and neck squamous cell carcinoma (HNSCC) based on high‐risk pathologic features, smoking, and outcomes using The Cancer Microbiome Atlas (TCMA). Study Design Database study. Setting Database review.
Delaney H. Sheehan, Kesava Asam, Nicolaus D. Knight, Juhi J. Patel, James A. Stewart, Patrick A. Molina, Nengjun Yi, Chi T. Viet, Brad Aouizerat, Natalie Silver, Bharat Panuganti, Carissa M. Thomas   +11 more
wiley   +1 more source

Time- and dose-dependent activation of the NLRP3 and MyD88/NF-κB pathways by Trueperella pyogenes membrane vesicles in bovine endometrial epithelial cells. [PDF]

Vet Res
Li D, Li H, Wang Z, Huang Y, Zhao C, Zhang H, Zhao Y, Zhu N, Tang X, Jin Y, Zhou D.   +10 more
europepmc   +1 more source

Arbutin improves lung injury in chicks induced by Mycoplasma gallisepticum infection. [PDF]

Poult Sci
Wan Z, Liu T, Cheng A, Li H, Lin R, Zhu E, Huang Y, Liu S, Tang Y, Shan C, Cheng Z.   +10 more
europepmc   +1 more source

NOX2/NLRP3-Inflammasome-Dependent Microglia Activation Promotes As(III)-Induced Learning and Memory Impairments in Developmental Rats. [PDF]

Toxics
Zhang L, Xiao Y, Wang D, Han X, Zhou R, Zhang H, Zhu K, Wu J, Sun X, Li S.   +9 more
europepmc   +1 more source