Results 311 to 320 of about 131,202 (338)

Hirudin inhibits ferroptosis to improve renal fibrosis by targeting the STAT3/NLRP3 signaling pathway. [PDF]

Acta Cir Bras
Lan F, Long C, Huang H, Xie Y, Shi W.
europepmc   +1 more source

KYNA Ameliorates Hepatic Ischemia–Reperfusion Injury by Activating the Hippo Signalling Pathway via FTO‐Dependent m6A Demethylation of LATS1

Cell Proliferation, EarlyView.
Our study elucidates the cellular and molecular mechanisms underlying KYNA's protective effects against HIRI. It emphasises that KYNA modulates the methylation status of the Hippo signalling pathway through the activation of AHR, thereby mitigating damage by promoting LATS1 degradation and facilitating the nuclear translocation of YAP. ABSTRACT Hepatic
Wenjie Zheng, Xiaowen Wang, Haoqi Chen, Kaiming He, Xijing Yan, Yuan Zhang, Yang Yang, Peng Zhang, Wenfeng Zhu, Shuguang Zhu, Hua Li   +10 more
wiley   +1 more source

Deciphering the Immunomodulatory Function of GSN+ Inflammatory Cancer‐Associated Fibroblasts in Renal Cell Carcinoma Immunotherapy: Insights From Pan‐Cancer Single‐Cell Landscape and Spatial Transcriptomics Analysis

Cell Proliferation, EarlyView.
Pan‐cancer scRNA‐seq and ST‐seq analyses identify GSN+ inflammatory cancer‐associated fibroblasts (CAFs) and their spatial distribution in immune checkpoint inhibitor (ICI) therapy. The Caf.Sig model accurately predicts ICI response across cancers using CAF gene signatures and machine learning.
Shan Li, Xinwei Zhou, Haoqian Feng, Kangbo Huang, Minyu Chen, Mingjie Lin, Hansen Lin, Zebing Deng, Yuhang Chen, Wuyuan Liao, Zhengkun Zhang, Jinwei Chen, Bohong Guan, Tian Su, Zihao Feng, Guannan Shu, Anze Yu, Yihui Pan, Liangmin Fu   +18 more
wiley   +1 more source

Post-symptomatic NLRP3 inhibition rescues cognitive impairment and mitigates amyloid and tau driven neurodegeneration. [PDF]

NPJ Dement
Auger A, Faidi R, Rickman AD, Martinez CP, Fajfer A, Carling J, Hilyard A, Ali M, Ono R, Cleveland C, Seliniotakis R, Truong N, Chefson A, Raymond M, Germain MA, Crackower MA, Heckmann BL.   +16 more
europepmc   +1 more source

Herbal Medicine for Colorectal Cancer Treatment: Molecular Mechanisms and Clinical Applications

Cell Proliferation, EarlyView.
Colorectal cancer is a prevalent gastrointestinal tumour and the second deadliest cancer worldwide, affecting approximately 10% of all cancers and cancer‐related deaths. Current clinical methods for treating CRC cause gastrointestinal abnormalities and myelosuppression.
Zuqing Su, Yanlin Li, Zihao Zhou, Bing Feng, Haiming Chen, Guangjuan Zheng   +5 more
wiley   +1 more source

Rutin ameliorates LPS-induced acute lung injury in mice by inhibiting the cGAS-STING-NLRP3 signaling pathway. [PDF]

Front Pharmacol
Zhou X, Wang Z, Wang Y, Xu G, Luo M, Zhang M, Li Y.   +6 more
europepmc   +1 more source

Inflammation in atherosclerotic cardiovascular disease: From diagnosis to treatment

European Journal of Clinical Investigation, EarlyView.
Inflammation in atherosclerotic cardiovascular disease. Residual inflammatory risk (RIR), defined by high‐sensitive C‐reactive protein (hsCRP) concentration of ≥2 mg/L, represents a strong predictor of future atherosclerotic cardiovascular disease (ASCVD) events. Although increased hsCRP values ≥2 mg/L might be detected in every three out of five ASCVD
Natalie Arnold, Wolfgang Koenig
wiley   +1 more source

The NLRP3 inflammasome is essential for IL-18 production in a murine model of macrophage activation syndrome

Disease Models & Mechanisms
Tara A. Gleeson, Christina Kaiser, Catherine B. Lawrence, David Brough, Stuart M. Allan, Jack P. Green   +5 more
doaj   +1 more source

Semaglutide and adenosine alleviate obesity-induced kidney injury, with observed modulation of the Txnip/NLRP3 pathway. [PDF]

Diabetol Metab Syndr
Wang S, Pan X, Liang R, Chen S.
europepmc   +1 more source

The Effect of GB1 on DSS-Induced Colitis in WT and Nlrp3^-/- Mice. [PDF]

Int J Mol Sci
Zhou Z, Wang L, Liao R, Chen Q, Liu C, Song J, Deng C, Huang X.   +7 more
europepmc   +1 more source