Aerobic glycolysis promotes NLRP3 inflammasome activation via NLRP3 lactylation
Cell Chemical BiologyBacteria-infected macrophages undergo pyroptosis to release inflammatory cytokines, which contributes to host defense. It has been known that activated macrophages involve metabolic reprogramming. However, the metabolic changes and the role of metabolites in pyroptotic macrophages are not fully understood.
Wei Liu +3 more
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The NLRP3 Inflammasome as a Pharmacological Target
Journal of Cardiovascular Pharmacology, 2019Abstract: NLRP3 is a cytosolic receptor member of the nucleotide-binding oligomerization domain NOD-like receptor family that surveys the intracellular environment for the presence of infection, pathogens, and metabolic alarms. Although the surveillance activity of NLRP3 is required to protect the host from several pathogens, uncontrolled ...
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