Results 271 to 280 of about 104,328 (314)

The Gut Microbiota-Polyphenol-NLRP3 Inflammasome Axis: A Key Regulatory Network Linking Diet to Chronic Inflammation. [PDF]

Nutrients
Mosca L, Pagano C, Tafuri MG, Di Maio G, Rejano-Gordillo CM, Della Marca R, D'Angelo S, Monda M, Messina G, Polito R, Perrone P.   +10 more
europepmc   +1 more source

Hydroxysafflor yellow a attenuates oxygen-glucose deprivation/ reoxygenation induced endothelial pyroptosis via PARP-1/NLRP3 pathway. [PDF]

Front Pharmacol
Huang Q, Shi S, Qian L, Wu Y, Mao B, Chen N, Qian C, Guo Y, Jin B.   +8 more
europepmc   +1 more source

Botulinum toxin type E alleviates trigeminal neuropathic pain via modulation of the HIF-1α-NLRP3 pathway. [PDF]

Front Toxicol
Son J, Kim Y, Ju J, Kim J, Nam J, Cha Y, Ahn D.   +6 more
europepmc   +1 more source

Galangin alleviates cold stress-induced splenic injury in Danzhou chickens by inhibiting NLRP3 inflammasome-mediated pyroptosis. [PDF]

Poult Sci
Tian X, Dai C, Fan W, Cheng C, Lu W, Peng H, Yang D.   +6 more
europepmc   +1 more source

NLR Inflammasomes in Viral Infections: From Molecular Mechanisms to Therapeutic Interventions. [PDF]

Viruses
Hou S, Shen X, Sun D, An Y, Zhou Y, Sun X, Wang S, Liu X, Zhu M, Zhao S, Liu Z, Wu X, Liu R.   +12 more
europepmc   +1 more source

Bone Marrow-Derived Macrophage NLRP3 Mediates Renal Fibrosis by triggering TGF-β/Smad3-mediated Macrophage-Myofibroblast Transition. [PDF]

Int J Biol Sci
Wang W, Li J, Zhong Y, Chen J, Wu L, Wan L, Huang XR, Ye Z, Yu X, Lan HY.   +9 more
europepmc   +1 more source

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Vasculitis and the NLRP3 inflammasome

Current Opinion in Rheumatology, 2023
Purpose of review Vasculitis are a group of heterogeneous conditions characterized by chronic inflammation of blood vessels, leading to tissue destruction and organ failure. Vasculitis is an inflammatory process in which immune effector cells infiltrate blood vessels and surrounding tissues.
Kamel, Hamzaoui, Agnès, Hamzaoui
openaire   +2 more sources

NLRP3 inflammasome inhibitor INF39 attenuated NLRP3 assembly in macrophages

International Immunopharmacology, 2021
INF39 is a nontoxic, irreversible, acrylate-based NLRP3 inhibitor and a further optimization of ethyl 2-((2-chlorophenyl) hydroxyl) methyl) acrylate (INF4E). However, the detail mechanism and the direct target of its anti-inflammatory activity is not clear. Here, we show that INF39 is a specific inhibitor for NLRP3 inflammasome activation.
Yuhua Shi, Qian Lv, Mengjie Zheng, Hongxiang Sun, Fushan Shi   +4 more
openaire   +2 more sources

LMP7 inhibits the activation of NLRP3 inflammasome through interaction with NLRP3

Biochemical and Biophysical Research Communications, 2020
The innate immune system recognizes pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) by coding pattern recognition receptors (PRRs). As a well-known inflammasome, NLRP3 plays an essential role in helping the host immune response and driving antiviral processes.
Jing Jin, Wenbiao Wang, Aixin Li, Jianguo Wu   +3 more
openaire   +2 more sources