Results 241 to 250 of about 119,018 (305)

Human NLRP3 inflammasome activation leads to formation of condensate at the microtubule organizing center. [PDF]

Sci Adv
Wang J, Wu M, Xiao L, Du G, Chen M, Magupalli VG, Dahlberg PD, Wu H, Jensen GJ.   +8 more
europepmc   +1 more source

Toxicity Differences Between Microplastics and Nanoplastics in Organs: From Molecular Mechanisms to Potential Therapeutic Strategies

Med Research, EarlyView.
This review systematically compares the size‐dependent toxicity of microplastics and nanoplastics in the intestine, liver, kidney, lung, and brain. Particle size determines bioavailability, barrier penetration, and injury mechanisms. Because of their small size and high surface reactivity, NPs readily cross the intestinal epithelium and blood–brain ...
Yixian Cheng, Junjie Chen, Rui Fu, Jiawei Zhang, Jianguang Jia, Wei Wang, Zheng Zhang, Peng Zhang, Haosong Chen, Huake Cao, Gang Li, Weiwei Sheng, Ting Li, Bo Chen, Guodong Cao   +14 more
wiley   +1 more source

Deciphering the NEK7-NLRP3 inflammasome assembly: from conformational activation to allosteric drug discovery. [PDF]

Front Immunol
Gu CL, Liu DD, Chen H, Wei XH, Shang HC.
europepmc   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Igalan attenuates sepsis-induced inflammation through covalent targeting of the NLRP3 inflammasome pathway. [PDF]

RSC Chem Biol
Hou C, Chen Y, Bi W, Gao L, Yu S, Zhang X, Chen Z, Wei T, Dusmatova DE, Mukhamatkhanova RF, Sham'yanov ID, Han L, Lu Z, Wang H, Mamadalieva NZ, Zeng K.   +15 more
europepmc   +1 more source

Circadian rhythms and chronotherapy in Alzheimer's disease: Mechanisms and therapeutic implications

Neuroprotection, EarlyView.
Circadian dysregulation contributes to Alzheimer's disease through sleep disruption, clock‐gene dysfunction, neuroinflammation, impaired proteostasis, and metabolic imbalance. These alterations promote cognitive decline and disease progression, while circadian biomarkers and chronotherapeutic interventions offer opportunities for precision diagnosis ...
Bivek Singh, Filippo Pigazzani, Roberto Manfredini   +2 more
wiley   +1 more source

Investigating the impact and mechanism of Licochalcone B derivative CTG12 on NLRP3 inflammasome. [PDF]

Cell Commun Signal
Bian S, Fang ZE, Wang L, Wang J, Dong M, Yang N, Wang J, Li L, Xu G.   +8 more
europepmc   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

From cytokine storm to renal scarring in diabetic kidney disease: Biomarkers, risk stratification, and precision therapeutics

Precision Medical Sciences, EarlyView.
Hyperglycemia‐driven cytokine activation initiates a sustained inflammatory cascade in diabetic kidney disease, promoting cellular injury and fibrogenic signaling. Integrating cytokine‐based biomarkers with risk stratification enables precision therapeutics that target inflammation and fibrosis, ultimately aiming to halt progression from early renal ...
Emmanuel Ifeanyi Obeagu
wiley   +1 more source

Inhibition of the NLRP3 Inflammasome With MCC950 Improves Gut Health in Huntington's Disease Mice. [PDF]

J Neurochem
Sarkar SK, Ekwudo MN, Lu D, Masson B, Kiridena P, van de Garde N, Renoir T, Vince JE, Deepagan VG, Hannan AJ, Gubert C.   +10 more
europepmc   +1 more source