Results 221 to 230 of about 102,344 (304)

Targeting the NLRP3 Inflammasome with Colchicine in COVID-19: Therapeutic Evidence and Future Implications for Influenza. [PDF]

Int J Mol Sci
Mitev V.
europepmc   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

The role of NLRP3 inflammasome in the development of postoperative ileus and its molecular mechanism in male mice. [PDF]

Physiol Rep
Zhang F, Sun B, Guo H.
europepmc   +1 more source

Biomimetic mineralization‐inspired formulation‐adjuvant integrated circRNA nanovaccine against COVID‐19

Interdisciplinary Medicine, EarlyView.
Inspired by the role of Mg2+ in stabilizing RNA secondary structures, we developed a one‐pot biomimetic mineralization method for synthesizing a circular RNA‐based nanovaccine (circRNA@FAiNVac) that integrates formulation and adjuvant functions. This nanovaccine exhibits potent immunostimulatory activation enabling multimodal immune responses and ...
Liangru Lin, Yingying Ren, Jing Li, Panxing Ren, Xinran Wang, Yixin Ding, Linsu Liu, Cong Liu, Zhou Li, Yan Liu, Dan Luo   +10 more
wiley   +1 more source

SIRT6 activation relieves neuropathic pain by restoring Nrf2 signaling and inhibiting NLRP3 inflammasome. [PDF]

Front Physiol
Hao X, Leng J, Tan J.
europepmc   +1 more source

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

NLRP3 Inflammasome Activation and Atherogenic Lipid Profile in Hemodialysis Patients. [PDF]

Ther Apher Dial
Abdelaziz MN, Elshabrawy N, Almenshawy A, Elsodany KA, Elkasabi HG, Hammad AA, Attia HH, Mokhtar K, ElSayed R, Samaan E.   +9 more
europepmc   +1 more source

Mitochondria‐targeted nanomedicine for cancer therapy: Targeting strategies, therapeutic mechanisms, and translational challenges

Interdisciplinary Medicine, EarlyView.
This review highlights recent advances in mitochondria‐targeted nanomedicine for cancer therapy. It summarizes key targeting strategies and delineates four principal therapeutic mechanisms: oxidative stress–induced mitochondrial dysfunction, disruption of energy metabolism, direct mitochondrial damage, and induction of immunogenic cell death.
Linfeng Xiao, Xiaowei Chang, Jun Zhang, Yinshan Hong, Wenhui Cao, Zhewu Zhao, Yu‐E. Wang, Yanling Yang   +7 more
wiley   +1 more source

Muscle Dysfunction in Critical Illness: Established Mechanisms and the Potential Contribution of the NLRP3 Inflammasome. [PDF]

Int J Mol Sci
Arellano-Pérez Ó, Arias-Díaz J, Jiménez-Oliva E, Valladares-Ide D, Jara L, Llanos P.   +5 more
europepmc   +1 more source

Experiencing 50 Years of Synergistic Development in Structural Biology and Enzymology

Journal of the Chinese Chemical Society, EarlyView.
Picture of Sunney Chan with Academia Sinica (AS) President James C. Liao and three Vice Presidents: Shin‐Kun Peng (left one), Tang K. Tang (right one), and Mei‐Yin Chou (right 2), taken at the annual Chinese New Year's Banquet of AS, February 7, 2025. This was likely Sunney's last appearance in formal activities of AS.
Ming‐Daw Tsai
wiley   +1 more source