Results 221 to 230 of about 119,018 (305)

The NLRP3 Inflammasome in Neuropsychiatric Disorders: Molecular Mechanisms and Emerging Therapeutic Strategies. [PDF]

Int J Mol Sci
Neamțu M, Petreuș T, Olinici DT, Stoica L, Arcan OD, Stoica BA, Moșoiu C.   +6 more
europepmc   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

A derivative of PD156707 selectively inhibits NLRP3 inflammasome activation by directly binding to NLRP3. [PDF]

Sci Rep
Jung YR, Fei X, Lee HM, Hasan A, Kim EJ, Byun KT, Seo SY, Kang TB, Lee KH.   +8 more
europepmc   +1 more source

Heavy Metal Mixture Exposure and Insulin Resistance in U.S. Adults: The Mediating Role of Systemic Inflammation

Journal of Clinical Laboratory Analysis, EarlyView.
In a nationally representative sample of 3042 U.S. adults from NHANES 2021–2023, blood lead, cadmium, and mercury, both individually and as a weighted quantile sum (WQS) mixture, were inversely associated with insulin resistance assessed by HOMA‐IR. Systemic inflammation, measured by high‐sensitivity C‐reactive protein (hs‐CRP), significantly mediated ...
Cai Zhang, Shidi Lin, Yu Lin
wiley   +1 more source

The Landscape of Biomarkers in ICU‐Associated AKI: From Protein Markers to Cell‐Free Nucleic Acids

Journal of Clinical Laboratory Analysis, EarlyView.
Acute kidney injury (AKI) in critically ill patients—particularly in sepsis—often develops early and is missed by creatinine/urine output–based criteria, delaying risk stratification and timely intervention. This review synthesizes current evidence on established and emerging AKI biomarkers (e.g., NGAL, KIM‐1, [TIMP‐2]·[IGFBP7]) alongside circulating ...
Qi Zhu, Feng Yang, Hua Zheng, Xinxin Guo, Zhijin Chen, Limin Chen, Daoli Wang, Jiaqi Wang, Xinmeng Wang, Zhiyuan Huang, Zhenhua Ji   +10 more
wiley   +1 more source

The Gut Microbiota-Polyphenol-NLRP3 Inflammasome Axis: A Key Regulatory Network Linking Diet to Chronic Inflammation. [PDF]

Nutrients
Mosca L, Pagano C, Tafuri MG, Di Maio G, Rejano-Gordillo CM, Della Marca R, D'Angelo S, Monda M, Messina G, Polito R, Perrone P.   +10 more
europepmc   +1 more source

Intelligent design of artificial biocatalyst for biomedical diseases

Journal of Intelligent Medicine, EarlyView.
This review summarizes recent advances in the intelligent design of artificial biocatalysts for biomedical diseases. By leveraging tailored design strategies, including environment‐responsive engineering and rational/artificial intelligence‐aided optimization, these biocatalysts enable precise modulation of pathological microenvironments and targeted ...
Lijie Zhang, Nan Song, Huanhuan Qiao, Si Sun   +3 more
wiley   +1 more source

Icariin attenuates diabetic cardiomyopathy by inhibiting NLRP3 inflammasome through SIRT3-mediated TFAM deacetylation. [PDF]

Front Pharmacol
Sun M, Huang H, Wei C, Xing Y, Wu B.
europepmc   +1 more source

Biological activities and bioactive constituents of Flammulina velutipes: An updated systematic review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti‐inflammatory, antitumor, immunomodulatory, and gut microbiota‐regulating effects.
Rıdvan Özgen, Didem Şöhretoğlu, Ayşe Kuruüzüm‐Uz   +2 more
wiley   +1 more source

MG53 protects against intestinal inflammation by inhibiting NLRP3 inflammasome activation. [PDF]

Front Pharmacol
Li Z, Dawson ZD, Li X, Zhao S, Bu M, Jiang F, Chen Y, Zhang M, Zeng X, Park KH, Lu J, He J, Lee K, Boyaka PN, Li H, Ma J.   +15 more
europepmc   +1 more source