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NLRP3 inflammasome in sepsis (Review)
Molecular Medicine Reports, 2021Sepsis is an imbalanced response to infection that leads to life-threatening organ dysfunction. Although an increasing number of anti-inflammatory drugs are available, the options for treating sepsis remain limited. Therefore, it is imperative to understand the pathogenesis and pathophysiology of sepsis and develop novel therapeutic targets to treat ...
Xueyan, Shi, Sichuang, Tan, Sipin, Tan
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The NLRP3 inflammasome: activation and regulation
Trends in Biochemical Sciences, 2023The NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome is a cytoplasmic supramolecular complex that is activated in response to cellular perturbations triggered by infection and sterile injury. Assembly of the NLRP3 inflammasome leads to activation of caspase-1, which induces the maturation and release of interleukin-1β (IL-1β) and ...
Jie, Xu, Gabriel, Núñez
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NLRP3 inflammasome in neurodegenerative disease
Translational Research, 2023Neurodegenerative diseases are characterized by a dysregulated neuro-glial microenvironment, culminating in functional deficits resulting from neuronal cell death. Inflammation is a hallmark of the neurodegenerative microenvironment and despite a critical role in tissue homeostasis, increasing evidence suggests that chronic inflammatory insult can ...
Faith L. Anderson +3 more
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NLRP3 inflammasome pathways in atherosclerosis [PDF]
Atherosclerosis, 2017 Atherosclerosis is the major cause of death and disability. Atherosclerotic plaques are characterized by a chronic sterile inflammation in the large blood vessels, where lipid-derived and damage-associated molecular patterns play important roles in inciting immune responses. Following the initial demonstration that NLR family Pyrin domain containing 3 (
Xuan Li, Marta Baldrighi, Ziad Mallat
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NLRP3 inflammasome in depression: A review
International Immunopharmacology, 2023The present article provides a detailed concept of the role of NLRP3 inflammasome in the pathophysiology of depression-like chronic diseases where inflammation and release of various cytokines plays a pivotal role in exaggerating the condition. The various pathways involved in NLRP3 activation are the main target of NLRP3 inhibitors for the therapeutic
Salona Roy +3 more
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Sensing damage by the NLRP3 inflammasome [PDF]
Immunological Reviews, 2011 Summary: The NLRP3 inflammasome is activated in response to a variety of signals that are indicative of damage to the host including tissue damage, metabolic stress, and infection. Upon activation, the NLRP3 inflammasome serves as a platform for activation of the cysteine protease caspase‐1, which leads to the processing and secretion of the ...
Jaklien C, Leemans +2 more
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Methods to Activate the NLRP3 Inflammasome
2023The inflammasome-nucleating cytoplasmic sensor protein NLRP3 (NACHT-, LRR, and PYD domains-containing protein 3, also known as NOD-like receptor pyrin domain-containing 3, NALP3, or cryopyrin) is triggered by a broad spectrum of sterile endogenous danger signals and environmental irritants. Upon activation, NLRP3 engages the adapter protein ASC that in
Benedikt S, Saller +2 more
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The NLRP3 Inflammasome as a Pharmacological Target
Journal of Cardiovascular Pharmacology, 2019Abstract: NLRP3 is a cytosolic receptor member of the nucleotide-binding oligomerization domain NOD-like receptor family that surveys the intracellular environment for the presence of infection, pathogens, and metabolic alarms. Although the surveillance activity of NLRP3 is required to protect the host from several pathogens, uncontrolled ...
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The NLRP3 Inflammasome in Alzheimer’s Disease
Molecular Neurobiology, 2013Innate immunity and inflammatory response plays an important role in the pathogenesis of Alzheimer's disease (AD). As the major resident immune cells in the brain, microglial cells constantly survey the microenvironment and are activated by and recruited to senile plaques.
Meng-Shan, Tan +4 more
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The Nlrp3 inflammasome admits defeat
Trends in Immunology, 2015The Nlrp3 inflammasome triggers interleukin-1 secretion by myeloid cells in response to endogenous and exogenous danger signals. Two recent studies identified the sulfonylurea MCC950 and the ketone metabolite β-hydroxybutyrate as specific inhibitors of the Nlrp3 inflammasome, with promising therapeutic potential for the treatment of auto-inflammatory ...
Christina J. Groß, Olaf Groß
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