Results 271 to 280 of about 119,018 (305)
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Targeting the NLRP3 inflammasome in inflammatory diseases
Nature Reviews Drug Discovery, 2018Eicke Latz, Latz Eicke
exaly +2 more sources
NLRP3 inflammasome activation: the convergence of multiple signalling pathways on ROS production?
Nature Reviews Immunology, 2010Kate Schröder +2 more
exaly +2 more sources
Vasculitis and the NLRP3 inflammasome
Current Opinion in Rheumatology, 2023Purpose of review Vasculitis are a group of heterogeneous conditions characterized by chronic inflammation of blood vessels, leading to tissue destruction and organ failure. Vasculitis is an inflammatory process in which immune effector cells infiltrate blood vessels and surrounding tissues.
Kamel, Hamzaoui, Agnès, Hamzaoui
openaire +2 more sources
NLRP3 inflammasome in neurodegenerative disease
Translational Research, 2023Neurodegenerative diseases are characterized by a dysregulated neuro-glial microenvironment, culminating in functional deficits resulting from neuronal cell death. Inflammation is a hallmark of the neurodegenerative microenvironment and despite a critical role in tissue homeostasis, increasing evidence suggests that chronic inflammatory insult can ...
Faith L. Anderson +3 more
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The role of mitochondria in NLRP3 inflammasome activation.
Molecular Immunology, 2018The NLRP3 inflammasome is a multiprotein platform which is activated upon cellular infection or stress. Its activation leads to caspase-1-dependent secretion of proinflammatory cytokines like interleukin-1β (IL-1β) and IL-18, and an inflammatory form of ...
Qiuyu Liu +4 more
semanticscholar +1 more source
NLRP3 inflammasome in sepsis (Review)
Molecular Medicine Reports, 2021Sepsis is an imbalanced response to infection that leads to life-threatening organ dysfunction. Although an increasing number of anti-inflammatory drugs are available, the options for treating sepsis remain limited. Therefore, it is imperative to understand the pathogenesis and pathophysiology of sepsis and develop novel therapeutic targets to treat ...
Xueyan, Shi, Sichuang, Tan, Sipin, Tan
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NLRP3 inflammasome in depression: A review
International Immunopharmacology, 2023The present article provides a detailed concept of the role of NLRP3 inflammasome in the pathophysiology of depression-like chronic diseases where inflammation and release of various cytokines plays a pivotal role in exaggerating the condition. The various pathways involved in NLRP3 activation are the main target of NLRP3 inhibitors for the therapeutic
Salona Roy +3 more
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The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases
Nature Reviews Cardiology, 2023An intense, stereotyped inflammatory response occurs in response to ischaemic and non-ischaemic injury to the myocardium. The NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome is a finely regulated macromolecular protein complex that ...
S. Toldo, Antonio Abbate
semanticscholar +1 more source
Updated insights into the molecular networks for NLRP3 inflammasome activation
Cellular & Molecular ImmunologyOver the past decade, significant advances have been made in our understanding of how NACHT-, leucine-rich-repeat-, and pyrin domain-containing protein 3 (NLRP3) inflammasomes are activated.
Seungwha Paik +5 more
semanticscholar +1 more source
Cryo-EM structures of the active NLRP3 inflammasome disc
Nature, 2022We report cryogenic electron microscopy structures of disc-shaped active NLRP3 oligomers in complex with NEK7 and ASC, and propose that the role of NEK7 is to transform NLRP3 into the active NLRP3 inflammasome disc.
Le Xiao, V. Magupalli, Hao Wu
semanticscholar +1 more source