Results 271 to 280 of about 108,275 (303)
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Vasculitis and the NLRP3 inflammasome
Current Opinion in Rheumatology, 2023Purpose of review Vasculitis are a group of heterogeneous conditions characterized by chronic inflammation of blood vessels, leading to tissue destruction and organ failure. Vasculitis is an inflammatory process in which immune effector cells infiltrate blood vessels and surrounding tissues.
Kamel, Hamzaoui, Agnès, Hamzaoui
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The NLRP3 inflammasome: activation and regulation
Trends in Biochemical Sciences, 2023The NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome is a cytoplasmic supramolecular complex that is activated in response to cellular perturbations triggered by infection and sterile injury. Assembly of the NLRP3 inflammasome leads to activation of caspase-1, which induces the maturation and release of interleukin-1β (IL-1β) and ...
Jie, Xu, Gabriel, Núñez
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NLRP3 inflammasome in neurodegenerative disease
Translational Research, 2023Neurodegenerative diseases are characterized by a dysregulated neuro-glial microenvironment, culminating in functional deficits resulting from neuronal cell death. Inflammation is a hallmark of the neurodegenerative microenvironment and despite a critical role in tissue homeostasis, increasing evidence suggests that chronic inflammatory insult can ...
Faith L. Anderson +3 more
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NLRP3 inflammasome in sepsis (Review)
Molecular Medicine Reports, 2021Sepsis is an imbalanced response to infection that leads to life-threatening organ dysfunction. Although an increasing number of anti-inflammatory drugs are available, the options for treating sepsis remain limited. Therefore, it is imperative to understand the pathogenesis and pathophysiology of sepsis and develop novel therapeutic targets to treat ...
Xueyan, Shi, Sichuang, Tan, Sipin, Tan
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NLRP3 inflammasome in depression: A review
International Immunopharmacology, 2023The present article provides a detailed concept of the role of NLRP3 inflammasome in the pathophysiology of depression-like chronic diseases where inflammation and release of various cytokines plays a pivotal role in exaggerating the condition. The various pathways involved in NLRP3 activation are the main target of NLRP3 inhibitors for the therapeutic
Salona Roy +3 more
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The NLRP3 Inflammasome as a Pharmacological Target
Journal of Cardiovascular Pharmacology, 2019Abstract: NLRP3 is a cytosolic receptor member of the nucleotide-binding oligomerization domain NOD-like receptor family that surveys the intracellular environment for the presence of infection, pathogens, and metabolic alarms. Although the surveillance activity of NLRP3 is required to protect the host from several pathogens, uncontrolled ...
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Methods to Activate the NLRP3 Inflammasome
2023The inflammasome-nucleating cytoplasmic sensor protein NLRP3 (NACHT-, LRR, and PYD domains-containing protein 3, also known as NOD-like receptor pyrin domain-containing 3, NALP3, or cryopyrin) is triggered by a broad spectrum of sterile endogenous danger signals and environmental irritants. Upon activation, NLRP3 engages the adapter protein ASC that in
Benedikt S, Saller +2 more
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NLRP3 inflammasome activation in inflammaging
Seminars in Immunology, 2018The process of aging is associated with the appearance of low-grade subclinical inflammation, termed inflammaging, that can accelerate age-related diseases. In Western societies the age-related inflammatory response can additionally be aggravated by an inflammatory response related to modern lifestyles and excess calorie consumption, a pathophysiologic
Latz, Eicke, Duewell, Peter
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Targeting the NLRP3 inflammasome in psoriasis
International Journal of DermatologyAbstractThe NLRP3 inflammasome, a complex consisting of the nucleotide‐binding oligomerization domain, leucine‐rich repeat, and pyrin domain‐containing protein 3, has emerged as a critical mediator of pathological inflammation and a significant therapeutic target for various inflammatory diseases.
Xiuhui Chen +5 more
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The NLRP3 Inflammasome in Alzheimer’s Disease
Molecular Neurobiology, 2013Innate immunity and inflammatory response plays an important role in the pathogenesis of Alzheimer's disease (AD). As the major resident immune cells in the brain, microglial cells constantly survey the microenvironment and are activated by and recruited to senile plaques.
Meng-Shan, Tan +4 more
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