Results 281 to 290 of about 108,275 (303)

The Nlrp3 inflammasome admits defeat

Trends in Immunology, 2015
The Nlrp3 inflammasome triggers interleukin-1 secretion by myeloid cells in response to endogenous and exogenous danger signals. Two recent studies identified the sulfonylurea MCC950 and the ketone metabolite β-hydroxybutyrate as specific inhibitors of the Nlrp3 inflammasome, with promising therapeutic potential for the treatment of auto-inflammatory ...
Christina J. Groß, Olaf Groß
openaire   +2 more sources

Cardiovascular Pharmacology of the NLRP3 Inflammasome

Journal of Cardiovascular Pharmacology, 2019
Antonio, Abbate, George W, Booz
openaire   +2 more sources

Drugging the NLRP3 inflammasome: from signalling mechanisms to therapeutic targets

Nature Reviews Drug Discovery, 2023
Mohamed Lamkanfi
exaly  

NLRP3 inflammasome activation and cell death

Cellular and Molecular Immunology, 2021
Yi Huang, Rongbin Zhou
exaly  

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

Cell Metabolism, 2020
Alexander Hooftman, Stefano Angiari, Marah C Runtsch   +2 more
exaly  

An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance

Cell Metabolism, 2020
Ming, Hanzhi Luo, Qi Qiao
exaly  

The orphan receptor Nur77 binds cytoplasmic LPS to activate the non-canonical NLRP3 inflammasome

Immunity, 2023
Pengyan Xia
exaly  

Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling

Immunity, 2022
Hongxu Xian, Kosuke Watari, Elsa - Sanchez-Lopez   +2 more
exaly  

The NLRP3 inflammasome: molecular activation and regulation to therapeutics

Nature Reviews Immunology, 2019
Karen V Swanson, Meng Deng, Jenny Ting
exaly  

Targeting the NLRP3 inflammasome in inflammatory diseases

Nature Reviews Drug Discovery, 2018
Eicke Latz
exaly