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Targeting the NLRP3 inflammasome for inflammatory disease therapy
TIPS - Trends in Pharmacological SciencesThe NOD-like receptor pyrin domain-containing 3 (NLRP3) inflammasome is a megadalton complex implicated in numerous inflammation-driven diseases including COVID-19, Alzheimer’s disease, and gout.
J. Cabral +5 more
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Methods to Activate the NLRP3 Inflammasome
2023The inflammasome-nucleating cytoplasmic sensor protein NLRP3 (NACHT-, LRR, and PYD domains-containing protein 3, also known as NOD-like receptor pyrin domain-containing 3, NALP3, or cryopyrin) is triggered by a broad spectrum of sterile endogenous danger signals and environmental irritants. Upon activation, NLRP3 engages the adapter protein ASC that in
Benedikt S, Saller +2 more
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The NLRP3 Inflammasome as a Pharmacological Target
Journal of Cardiovascular Pharmacology, 2019Abstract: NLRP3 is a cytosolic receptor member of the nucleotide-binding oligomerization domain NOD-like receptor family that surveys the intracellular environment for the presence of infection, pathogens, and metabolic alarms. Although the surveillance activity of NLRP3 is required to protect the host from several pathogens, uncontrolled ...
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NLRP3 inflammasome activation in inflammaging
Seminars in Immunology, 2018The process of aging is associated with the appearance of low-grade subclinical inflammation, termed inflammaging, that can accelerate age-related diseases. In Western societies the age-related inflammatory response can additionally be aggravated by an inflammatory response related to modern lifestyles and excess calorie consumption, a pathophysiologic
Latz, Eicke, Duewell, Peter
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Targeting the NLRP3 inflammasome in psoriasis
International Journal of DermatologyAbstractThe NLRP3 inflammasome, a complex consisting of the nucleotide‐binding oligomerization domain, leucine‐rich repeat, and pyrin domain‐containing protein 3, has emerged as a critical mediator of pathological inflammation and a significant therapeutic target for various inflammatory diseases.
Xiuhui Chen +5 more
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The NLRP3 Inflammasome in Alzheimer’s Disease
Molecular Neurobiology, 2013Innate immunity and inflammatory response plays an important role in the pathogenesis of Alzheimer's disease (AD). As the major resident immune cells in the brain, microglial cells constantly survey the microenvironment and are activated by and recruited to senile plaques.
Meng-Shan, Tan +4 more
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Regulation of the NLRP3 inflammasome by autophagy and mitophagy
Immunological ReviewsThe NLRP3 inflammasome is a multiprotein complex that upon activation by the innate immune system drives a broad inflammatory response. The primary initial mediators of this response are pro‐IL‐1β and pro‐IL‐18, both of which are in an inactive form ...
Suman Gupta +3 more
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The Nlrp3 inflammasome admits defeat
Trends in Immunology, 2015The Nlrp3 inflammasome triggers interleukin-1 secretion by myeloid cells in response to endogenous and exogenous danger signals. Two recent studies identified the sulfonylurea MCC950 and the ketone metabolite β-hydroxybutyrate as specific inhibitors of the Nlrp3 inflammasome, with promising therapeutic potential for the treatment of auto-inflammatory ...
Christina J. Groß, Olaf Groß
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A role for mitochondria in NLRP3 inflammasome activation
Nature, 2011Rongbin Zhou +3 more
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Cardiovascular Pharmacology of the NLRP3 Inflammasome
Journal of Cardiovascular Pharmacology, 2019Antonio, Abbate, George W, Booz
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