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Targeting the NLRP3 inflammasome in psoriasis
International Journal of DermatologyAbstractThe NLRP3 inflammasome, a complex consisting of the nucleotide‐binding oligomerization domain, leucine‐rich repeat, and pyrin domain‐containing protein 3, has emerged as a critical mediator of pathological inflammation and a significant therapeutic target for various inflammatory diseases.
Xiuhui Chen +5 more
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NLRP3 inflammasome activation in inflammaging
Seminars in Immunology, 2018The process of aging is associated with the appearance of low-grade subclinical inflammation, termed inflammaging, that can accelerate age-related diseases. In Western societies the age-related inflammatory response can additionally be aggravated by an inflammatory response related to modern lifestyles and excess calorie consumption, a pathophysiologic
Latz, Eicke, Duewell, Peter
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NLRP3 inflammasome activation and cell death
Cellular and Molecular Immunology, 2021Rongbin Zhou, Yi Huang
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Mitochondrial DNA in NLRP3 inflammasome activation
International Immunopharmacology, 2022Wenling Zhang
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An update on the regulatory mechanisms of NLRP3 inflammasome activation
Cellular and Molecular Immunology, 2021Jo Eun-Kyeong +2 more
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The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation
Cell Metabolism, 2020Anne McGettrick +2 more
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Mechanism and Regulation of NLRP3 Inflammasome Activation
Trends in Biochemical Sciences, 2016Hideki Hara, Gabriel Nunez, Yuan He
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Molecular mechanisms regulating NLRP3 inflammasome activation
Cellular and Molecular Immunology, 2015Jo Eun-Kyeong +2 more
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