Results 91 to 100 of about 61,577 (309)

Alkyl Protocatechuate-Loaded Nanostructured Lipid Systems as a Treatment Strategy for Paracoccidioides brasiliensis and Paracoccidioides lutzii In Vitro

Frontiers in Microbiology, 2017
Dodecyl protocatechuate (dodecyl) is a derivative of protocatechuic acid (3,4-dihydroxybenzoic acid) that possesses anti-oxidant and antifungal properties.
Kaila P. Medina-Alarcón, Junya L. Singulani, Aline R. Voltan, Janaina C. O. Sardi, Maicon S. Petrônio, Mariana B. Santos, Carlos R. Polaquini, Luis O. Regasini, Vanderlan S. Bolzani, Dulce H. S. da Silva, Marlus Chorilli, Maria J. S. Mendes-Giannini, Ana M. Fusco-Almeida   +12 more
doaj   +1 more source

Cancer‐Associated Fibroblasts Promote Tumor Immunosuppression in Hepatocellular Carcinoma via the NNMT‐ANGPTL4 Axis

Advanced Science, EarlyView.
ABSTRACT Background & Aims: Cancer‐associated fibroblasts (CAFs) drive immunosuppression in hepatocellular carcinoma (HCC). However, their metabolic regulation remains poorly defined. We investigated the role of nicotinamide N‐methyltransferase (NNMT) in CAFs. Approach & Results: High NNMT expression in CAF tissues was confirmed by western blotting and
Shounan Lu, Shanjia Ke, Hongjun Yu, Zhanzhi Meng, Miaoyu Bai, Yanan Xu, Hui Zhu, Jinwen Yang, Baolin Qian, Bing Yin, Chaoqun Wang, Zhigang Feng, Zhongyu Li, Yongzhi Zhou, Zihao Li, Xinglong Li, Yongliang Hua, Yao Fu, Wei Tang, Yaohua Wu, Yong Ma   +20 more
wiley   +1 more source

The structure of the FUS-NLS/Trn1 complex.

, 2012
(A) The overall structure. (B) The 2Fo − Fc composite omit electron density map around the FUS-NLS fragment (residues 508–526) contoured at 1.0 σ (gray mesh). The Trn1 and the FUS-NLS are shown in cyan and yellow, respectively. (C) The superimposition of
Liuqing Yang (128705), Chunyan Niu (128700), Jiayu Zhang (128702), Feng Gao (3548), Weimin Gong (120989), Minze Jia (128708), Haining Zhu (128711)   +6 more
core   +1 more source

Nongauge bright soliton of the nonlinear Schrödinger (NLS) equation and a family of generalized NLS equations [PDF]

, 2016
"We present an approach to the bright soliton solution of the nonlinear Schrödinger (NLS) equation from the standpoint of introducing a constant potential term in the equation.
Marco A. Reyes, Gutierrez-Ruiz, D., D. Gutierrez-Ruiz, Rosu Barbus, Haret-Codratian, Reyes, M. A., Stefan C. Mancas, Rosu, H. C., Mancas, S. C.   +7 more
core   +1 more source

Fine‐Tuned Regulation of mRNA Translation and Transport by STAU2 Condensate Facilitates Neuronal Development and Plasticity

Advanced Science, EarlyView.
STAU2 undergoes phase separation to form dynamic condensates that package target mRNAs and deliver them to the distal ends of growing neuronal dendrites. STAU2 condensates stabilize embedded mRNAs and repress their translation. Synaptic activity bidirectionally remodels STAU2 condensates, coordinating local translation of STAU2‐associated mRNAs ...
Shijing Huang, Yuanyuan Chu, Ruiqian Zhao, Siyu Li, Yu Feng, Hongdan Zheng, Yunli Xie, Tong Wang, Wenyu Wen   +8 more
wiley   +1 more source

NLS and NES signals.

, 2014
Superimposed models of FABP4 and MvFABPs;FABP4 (red); MVFABPa (green); MvFABPb (blue). A) FABP4-MvFABPa-MvFABPb; B–C) NLS region; D–E) NES region.
Gabriela Alvite (85281), Margot Paulino (649425), Adriana Esteves (85284), Natalia Garrido (649424), Alejandra Kun (587891)   +4 more
core   +1 more source

Localizable Fluorescent Metal Ion Indicators With Tunable Colors

Advanced Science, EarlyView.
A modular platform enables the generation of fluorescent metal ion indicators with tunable emission colors and precise subcellular localization. Conjugation to self‐labeling proteins yields bright, color‐tunable potassium probes that permit wash‐free live‐cell imaging, revealing dynamic potassium efflux in stimulated neurons.
Ming‐Ming Wang, De‐en Sun, Klara Gries, Kai Johnsson   +3 more
wiley   +1 more source

Codelivery of Raloxifene and Rutin as PEGylated Nanoliposomes: Formulation, Characterization, and Prophylactic Activity Against Breast Cancer [PDF]

Advanced Pharmaceutical Bulletin
Purpose: Breast cancer is the leading cause of cancer-related deaths among women. Chemotherapy faces challenges such as systemic toxicity and multidrug resistance. Advances in nanotechnology have led researchers to develop safer and more efficient cancer
Maryam Abdulmaged Oleiwi, Ali Al-Samydai, Aya Y. Al-Kabariti, Khaldun M. Al Azzam, Simone Carradori, Walhan Alshaer   +5 more
doaj   +1 more source

Calpain nls::mrfp expression in non-neuronal tissues.

, 2012
Co-localization of the myo-3p::gfp::nls body wall muscle reporter with (A) clp-1p::nls::mrfp (crEx65) and (B) clp-4p::mrfp (crEx74). Co-localization of the pes-6::gfp excretory cell reporter with (C) clp-4p::nls::mrfp (crEx74), (D) tra-3p::nls::mrfp ...
Peter I. Joyce (174897), Rahul Satija (174900), Maozi Chen (174903), Patricia E. Kuwabara (174907)   +3 more
core   +1 more source

A High‐Throughput Live Imaging Platform to Investigate Circuit‐Dependent Regulation of Circadian Rhythms in Brain Tissue

Advanced Science, EarlyView.
Biological rhythms coordinate physiology, from genes to behavior. Study of circadian rhythms in brain tissue is constrained by limited throughput and spatial and temporal information quality. A new platform for high‐throughput, long‐term multiplexed fluorescent live imaging of circadian rhythms in brain slices is introduced.
Marco Ferrari, Natalie Ness, Julieta Acosta, Marco Brancaccio   +3 more
wiley   +1 more source