Results 81 to 90 of about 61,577 (309)

Anti‐PD‐1 Nanobody‐Armored MSLN CAR‐T Therapy for Malignant Mesothelioma: Preclinical and Clinical Studies

Advanced Science, EarlyView.
A novel therapy using engineered immune cells (NAC‐T cells) showed promise for refractory malignant mesothelioma. Based on the encouraging preclinical data, the first‐in‐human trial is initiated, demonstrating tolerable safety and promising anti‐tumor activity (ORR 63.6%, DCR 100%, including one CR).
Yan Sun, Haochen Yang, Qing Xu, Xingya Li, Jinxing Lou, Jianchun Duan, Jiachen Xu, Zhuqing Liu, Yong Xia, Zhicai Lin, Linlin Li, Dan Sun, Jiaguo Li, Tao Liu, Jun Guo, Wenfeng Xu, Weimin Zhu, Yi Liu, Boyang Sun, Jia Zhong, Lijie Rong, Qijun Qian, Chenqi Xu, Jie Wang   +23 more
wiley   +1 more source

7 Tesla magnetic resonance imaging to detect cortical pathology in multiple sclerosis. [PDF]

PLoS ONE, 2014
Neocortical lesions (NLs) are an important pathological component of multiple sclerosis (MS), but their visualization by magnetic resonance imaging (MRI) remains challenging.We aimed at assessing the sensitivity of multi echo gradient echo (ME-GRE) T2 ...
Bing Yao, Simon Hametner, Peter van Gelderen, Hellmuth Merkle, Christina Chen, Hans Lassmann, Jeff H Duyn, Francesca Bagnato   +7 more
doaj   +1 more source

The predicted NLS of PABP2 is not an NLS. A)

, 2013
Fluorescent microscopy images of cells expressing PABP1-eYFP/PABP2-mChFP either untreated or treated with sinefungin (2 µg/ml), heat shock (41°C) or both sinefungin and heat shock for two hours.
Steve Kelly (277827), Mark C. Field (129657), Bridget Bannerman-Chukualim (277825), Susanne Kramer (37790), Mark Carrington (1398), Louise Ellis (8369), Elizabeth A. Boulden (277826)   +6 more
core   +1 more source

LC3B Mediated SETDB1‐Accounted Alcoholic Steatohepatitis via Lipidation‐Dependent LAP and Lipidation‐Independent Nuclear Stabilization

Advanced Science, EarlyView.
SETDB1 is progressively downregulated in ALD, correlating with disease severity. SETDB1 deficiency impairs LAP by disrupting Rubicon membrane localization, leading to defective lipid droplet clearance. Concurrently, loss of SETDB1 reduces nuclear LC3B, causing R‐loop accumulation and cGAS‐STING‐driven inflammation. Lipidated LC3B mediates LAP‐dependent
Yi Zhang, Tan Wei, Jiahang Wu, Chuixu Lin, Dongbo Zhu, Yanhui Li, Shuting Shi, Shishun Huang, Leiming Jiang, Hongzhi Wang, Meiqi Song, Pengfei Gao, Xu Wu, Mingjian Fan, Chaofeng Wei, Qian Wang, Lihui Qu, Zhigang Wang   +17 more
wiley   +1 more source

Lauflumide (NLS-4) Is a New Potent Wake-Promoting Compound [PDF]

, 2018
International audiencePsychostimulants are used for the treatment of excessive daytime sleepiness in a wide range of sleep disorders as well as in attention deficit hyperactivity disorder or cognitive impairment in neuropsychiatric disorders.
Bandarabadi, Mojtaba, Ferrié, L., Ferrié, Laurent, Michel Lecendreux, Bruno Figadère, Konofal, E., Eric Konofal, Luca, Gianina, Laurent Ferrié, Figadère, Bruno, Lecendreux, M., Luca, G., Konofal, Eric, Bandarabadi, M., Tafti, M., Figadère, B., Mojtaba Bandarabadi, Gianina Luca, Lecendreux, Michel, Mehdi Tafti, Tafti, Mehdi   +20 more
core   +2 more sources

Hijacking the Host Clock: A Nematode Effector Antagonizes Soybean Circadian Defense and Translation Control

Advanced Science, EarlyView.
Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang, Yufeng Xu, Yanfei Hu, Lijun Cao, Ru Jiang, Changtian Chen, Rick Masonbrink, Thomas Maier, Yuchen Tu, Yabo Shi, Enhui Liu, Lingan Kong, Chan Guo, Wei Zhao, Peng Shi, Wenzhen Du, Andrew Severin, Thomas Baum, Deliang Peng, Huan Peng, Mian Zhou, Wei Wang   +21 more
wiley   +1 more source

Interplay between kinase domain autophosphorylation and F-actin binding domain in regulating imatinib sensitivity and nuclear import of BCR-ABL. [PDF]

PLoS ONE, 2011
The constitutively activated BCR-ABL tyrosine kinase of chronic myeloid leukemia (CML) is localized exclusively to the cytoplasm despite the three nuclear localization signals (NLS) in the ABL portion of this fusion protein.
Martin Preyer, Paolo Vigneri, Jean Y J Wang   +2 more
doaj   +1 more source

Desenvolvimento de nanopartícula lipídica sólida contendo um análogo de pirimidina e avaliação in vitro da atividade antitumoral [PDF]

, 2014
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Farmácia, Florianópolis, 2014Esta tese está sendo apresentada em quatro etapas.
Dal Pizzol, Carine
core  

Comparative analysis of nuclear localization signal (NLS) prediction methods

, 2017
Aim. Comparative analysis of six state-of-the-art nuclear localization signal (NLS) prediction methods (PSORT II, NucPred, cNLSMapper, NLStradamus, NucImport and seqNLS). Methods.
Seplyarskiy, V.B., Sheval, E.V., O. M. Lisitsyna, Lisitsyna, O.M., E. V. Sheval, V. B. Seplyarskiy   +5 more
core   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source