Results 101 to 110 of about 142,714 (313)

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

Advanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong, Guangyu Liang, Huimin Yu, Jiaqi Li, Ruohong Wang, Xiaohong Ma, Ziqing Zhou, Yin Zhao, Fei Sun, Xufang Sun   +9 more
wiley   +1 more source

Rational soliton solutions of nonlocal multicomponent nonlinear Schrödinger equations

Partial Differential Equations in Applied Mathematics, 2022
In this paper, we present a generalized Darboux transformation for nonlocal multicomponent nonlinear Schrödinger (NLS) equations. Also, we provide a unified formula for Nth-order rational soliton solution of discussed nonlocal multicomponent NLS ...
Li-Na Zheng, Yu-Shan Bai
doaj  

A Dual‐Targeting T6SS DNase Drives Bacterial Antagonism and Eukaryotic Apoptosis via the cGAS‐STING‐TNF Axis

Advanced Science, Volume 12, Issue 28, July 24, 2025.
The bacterial Type VI secretion system (T6SS) emerges as a sophisticated virulence mechanism, leveraging the dual‐function effector TkeA from Yersinia pseudotuberculosis. TkeA concurrently damages rival bacteria and host cell DNA, triggering the host's cGAS‐STING‐TNF pathway and inducing apoptosis.
Li Song, Lei Xu, Pengfei Zhang, Shuying Li, Yichen Qu, Yixin Zhao, Zhenkun Shi, Ruiqi Ma, Yongdong Li, Yi Chen, Yao Wang, Zhengfan Jiang, Gehong Wei, Xihui Shen   +13 more
wiley   +1 more source

Transparent and Transient Flexible Electronics

Advanced Science, EarlyView.
Transparent electronics has gained tremendous attention in recent years because of the growing demand for see‐through devices in applications such as displays, windscreens, and wearables. This review discusses the recent developments related to transparent electronics as well as the challenges associated with the development of flexible and transient ...
Nitheesh M. Nair, Ayoub Zumeit, Ravinder Dahiya   +2 more
wiley   +1 more source

ALKBH5‐Mediated M6A Demethylation of G3BP1 Attenuates Ferroptosis Via Cytoplasmic Retention of YBX1/p53 in Diabetic Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
ALKBH5 promoted G3BP1 expression via m⁶A methylation at sites 142/173. G3BP1 interacts with YBX1 and p53, reducing their nuclear translocation and decreasing p53‐mediated SLC7A11 repression. This inhibites cardiomyocyte ferroptosis and mitigates myocardial damage during diabetic ischemia‐reperfusion injury.
Wenyuan Li, Wei Li, Yan Leng, Heng Xu, Zhongyuan Xia, Yao Wang   +5 more
wiley   +1 more source

3D Topological Inorganic Electrides: Screening, Properties, and Applications

Advanced Science, EarlyView.
In inorganic electrides, zero‐, one‐, and two‐dimensional (0D, 1D, and 2D) interstitial anionic electrons interconnect within lattice cavities, collectively forming a three‐dimensional (3D) network, further coupling magnetism and topological features, leading to the emergence of 3D topological inorganic electrides.
Zhenzhou Guo, Weizhen Meng, Qianwen Zhang, Xia Cheng, Shiyao Wang, Yalong Jiao, Xiaoming Zhang, Ying Liu, Tie Yang   +8 more
wiley   +1 more source

Symmetry broken and unbroken solutions of nonlocal NLS equation in 2+1 dimensions

Results in Physics, 2020
In this paper, we study a general nonlinear Schrödinger (NLS) equation in 2+1 dimensions which under appropriate nonlocal symmetry reduction leads to reverse space nonlocal NLS equation. We apply Darboux transformation and construct multiple solutions of
H. Sarfraz, U. Saleem
doaj  

Intrazellulärer Transport nativer Proteine durch Bioreversible Arginin‐Modifikation (BioRAM) primärer Aminogruppen

Angewandte Chemie, EarlyView.
Die Bioreversible Arginin‐Modifikation aminhaltiger Proteinreste (BioRAM) ermöglicht eine serumkompatible, leicht zugängliche und effiziente Einschleusung nativer Proteine in lebende Zellen. In Kombination mit zellpenetrierenden Peptid‐Additiven führt BioRAM zu nanomolarer intrazellulären RNase‐A‐Aktivität und erlaubt so den zellulären Transport ...
Jonathan Franke, Jan Vincent V. Arafiles, Christian Leis, Christian P. R. Hackenberger   +3 more
wiley   +1 more source

Integrable inhomogeneous NLS equations are equivalent to the standard NLS

, 2008
A class of inhomogeneous nonlinear Schr dinger equations (NLS), claiming to be novel integrable systems with rich properties continues appearing in PhysRev and PRL. All such equations are shown to be not new but equivalent to the standard NLS, which trivially explains their integrability features.
openaire   +2 more sources

Intracellular Delivery of Native Proteins by BioReversible Arginine Modification (BioRAM) on Amino Groups

Angewandte Chemie International Edition, EarlyView.
Bioreversible Arginine Modification of amine‐containing protein residues (termed BioRAM) allows the serum‐compatible, readily accessible, and efficient delivery of native proteins into live cells. Combined with cell‐penetrating peptide (CPP) additives, BioRAM results in intracellular RNase A activity at nanomolar concentrations, thus enabling the ...
Jonathan Franke, Jan Vincent V. Arafiles, Christian Leis, Christian P. R. Hackenberger   +3 more
wiley   +1 more source