Results 111 to 120 of about 157,319 (379)
Advanced Science, EarlyView.Under DNA damage, tumor cells rely on efficient DNA repair for survival and therapy resistance. This study has demonstrated that BCKDK localizes to breast cancer cell nuclei, where it binds to and phosphorylates RNF8, thereby blocking ubiquitin‐mediated degradation of RAD51 and enhancing HRR. A selective BCKDK inhibitor synergizes with clinical agents,
Haiying Liu +12 more
wiley +1 more source
On nonlinear Schr\"odinger equations with almost periodic initial data [PDF]
, 2015 We consider the Cauchy problem of nonlinear Schr\"odinger equations (NLS) with almost periodic functions as initial data. We first prove that, given a frequency set $\pmb{\omega} =\{\omega_j\}_{j = 1}^\infty$, NLS is local well-posed in the algebra ...
Oh, Tadahiro
core
Nonlinear Photonic Crystals: IV. Nonlinear Schrodinger Equation Regime
, 2005 We study here the nonlinear Schrodinger Equation (NLS) as the first term in a sequence of approximations for an electromagnetic (EM) wave propagating according to the nonlinear Maxwell equations (NLM).
Babin, Anatoli, Figotin, Alexander
core +1 more source
Small RNA Toxin‐Assisted Evolution of GC‐Preferred ErCas12a for Enhanced Genome Targeting Range
Advanced Science, EarlyView.ErCas12a is engineered to target GC‐rich PAMs using a small RNA toxin‐aided positive screening system. The resulting variant, enErCas12a, exhibits an expanded PAM profile and facilitates efficient gene editing in both bacterial and mammalian cells, while preserving high targeting specificity for both canonical and non‐canonical PAM targets.
Zehua Chen +8 more
wiley +1 more source
Data in Brief, 2023 53BP1 (TP53-binding protein 1), a key player in DNA double-strand break repair, has a classical bipartite nuclear localization signal (NLS) of sequence 1666-GKRKLITSEEERSPAKRGRKS-1686 that binds to importin-α, a nuclear import adaptor protein ...
Yoshiyuki Matsuura
doaj
Frontiers in Microbiology, 2017 Dodecyl protocatechuate (dodecyl) is a derivative of protocatechuic acid (3,4-dihydroxybenzoic acid) that possesses anti-oxidant and antifungal properties.
Kaila P. Medina-Alarcón +12 more
doaj +1 more source
Advanced Science, EarlyView.SCORT–Cas13d–pre‐gHoxB13 lipid nanoparticles precisely deliver Cas13d mRNA and guide RNAs to metastatic prostate tumors in the liver, knocking down the “undruggable” transcription factor HoxB13. This approach suppresses metastatic tumor growth, extends mouse survival, and does not induce major organ toxicity or immune activation, offering a safe and ...
Zhifen Cui +15 more
wiley +1 more source
Scattering-like phenomena of the periodic defocusing NLS equation [PDF]
, 2015 In this paper we prove approximation properties of the solutions of the defoucsing NLS equation on the circle by nearly linear flows. In addition we show that spatially periodic solutions of the defocusing NLS equation evolving in fractional Sobolev ...
T. Kappeler, B. Schaad, P. Topalov
semanticscholar +1 more source
$M$ -NL: Robust NL-Means Approach for PolSAR Images Denoising [PDF]
IEEE Geoscience and Remote Sensing Letters, 2019 This letter proposes a new method for polarimetric synthetic aperture radar (PolSAR) denoising. More precisely, it seeks to address a new statistical approach for weights computation in nonlocal (NL) approaches. The aim is to present a simple criterion using $M$ -estimators and to detect similar pixels in an image. A binary hypothesis test is used
Gordana Draskovic +2 more
openaire +3 more sources
Advanced Science, EarlyView.CRABP2 plays a dual role in colorectal cancer: it promotes proliferation and suppresses apoptosis through the nuclear CRABP2/RB1 axis and the cytoplasmic AFG3L2/SLC25A39 axis. Meanwhile, it inhibits colorectal liver metastasis via AFG3L2/PINK1/Parkin‐mediated mitophagy.
Chuanxin Tian +14 more
wiley +1 more source