Hydrocarbon molar water solubility predicts NMDA vs. GABAA receptor modulation. [PDF]
, 2014 BackgroundMany anesthetics modulate 3-transmembrane (such as NMDA) and 4-transmembrane (such as GABAA) receptors. Clinical and experimental anesthetics exhibiting receptor family specificity often have low water solubility. We hypothesized that the molar
Brosnan, Robert J, Pham, Trung L
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Berberis vulgaris extract-based Fe3O4 nanocomposites affect NMDA1 function and physical activity: Analysis of Grin1 expression in Syrian mice model of Experimental autoimmune encephalomyelitis [PDF]
Advanced Herbal Medicine, 2021 Background: Ionotropic glutamate NMDA receptors are multi-subunit proteins with few selective pharmacological ligands and are tentatively implicated in MS and other neurodegenerative disorders.
Fatemeh Noruzifard +2 more
doaj
Establishment of an adult zebrafish model of retinal neurodegeneration induced by NMDA [PDF]
International Journal of Ophthalmology, 2019 AIM: To establish a model of retinal neurodegeneration induced by N-Methyl-D-aspartic acid (NMDA) in adult zebrafish. METHODS: We compared the effects of three different NMDA delivery methods on retinal neurodegeneration in adult zebrafish: immersion (I.
Zhi-Wen Luo +10 more
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Nanoscale-targeted patch-clamp recordings of functional presynaptic ion channels [PDF]
, 2013 Important modulatory roles have been attributed to presynaptic NMDA receptors (NMDARs) located on cerebellar interneuron terminals. Evidence supporting a presynaptic location includes an increase in the frequency of mini events following the application ...
Benton, DCH +4 more
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Cells, 2020 Purpose: To investigate whether and how leukemia inhibitory factor (Lif) is involved in mediating the neuroprotective effects of Norrin on retinal ganglion cells (RGC) following excitotoxic damage.
Stefan Kassumeh +6 more
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The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans [PDF]
, 2009 Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)- type glutamate receptors.
Amaral +77 more
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Interaction of hypothalamic GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors controlling heart rate in rats [PDF]
, 1991 We have previously shown that microinjection of drugs that impair gamma-aminobutyric acid (GABA)-mediated synaptic inhibition into the dorsomedial hypothalamus (DMH) of rats generates cardiovascular and behavioral changes that mimic the response to ...
DiMicco, Joseph A., Soltis, Robert P.
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The effects of memantine on prepulse inhibition. [PDF]
, 2009 Reduced prepulse inhibition (PPI) of startle provides evidence of deficient sensorimotor gating in several disorders, including schizophrenia. The role of NMDA neurotransmission in the regulation of PPI is unclear, due to cross-species differences in the
Bergsma, F +4 more
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Treatment of Cerebral Ischemia Through NMDA Receptors: Metabotropic Signaling and Future Directions
Frontiers in Pharmacology, 2022 Excessive activation of N-methyl-d-aspartic acid (NMDA) receptors after cerebral ischemia is a key cause of ischemic injury. For a long time, it was generally accepted that calcium influx is a necessary condition for ischemic injury mediated by NMDA ...
Yuanyuan Li +20 more
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GABA\u3csub\u3eA\u3c/sub\u3e and excitatory amino acid receptors in dorsomedial hypothalamus and heart rate in rats [PDF]
, 1991 We have previously shown that microinjection of drugs that interfere with the function of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) into the hypothalamus produces cardiorespiratory and behavioral changes resembling those seen in ...
DiMicco, Joseph A., Soltis, Robert P.
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