Results 11 to 20 of about 110,343 (264)

Establishment of an adult zebrafish model of retinal neurodegeneration induced by NMDA [PDF]

International Journal of Ophthalmology, 2019
AIM: To establish a model of retinal neurodegeneration induced by N-Methyl-D-aspartic acid (NMDA) in adult zebrafish. METHODS: We compared the effects of three different NMDA delivery methods on retinal neurodegeneration in adult zebrafish: immersion (I.
Zhi-Wen Luo, Han-Tsing Wang, Ning Wang, Wei-Wei Sheng, Ming Jin, Ye Lu, Yi-Jiang Bai, Su-Qi Zou, Yu-Lian Pang, Hong Xu, Xu Zhang   +10 more
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Norrin Protects Retinal Ganglion Cells from Excitotoxic Damage via the Induction of Leukemia Inhibitory Factor

Cells, 2020
Purpose: To investigate whether and how leukemia inhibitory factor (Lif) is involved in mediating the neuroprotective effects of Norrin on retinal ganglion cells (RGC) following excitotoxic damage.
Stefan Kassumeh, Stephanie Leopold, Rudolf Fuchshofer, Carina N. Thomas, Siegfried G. Priglinger, Ernst R. Tamm, Andreas Ohlmann   +6 more
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NMDA Receptors in Astrocytes [PDF]

Neurochemical Research, 2019
Astrocytes support glutamatergic neurotransmission in the central nervous system through multiple mechanisms which include: (i) glutamate clearance and control over glutamate spillover due to operation of glutamate transporters; (ii) supply of obligatory glutamate precursor glutamine via operation of glutamate-glutamine shuttle; (iii) supply of L ...
Alexei Verkhratsky, Alexandr Chvátal
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Visual Attention Decits in Schizophrenia Can Arise From Inhibitory Dysfunction in Thalamus or Cortex

Computational Psychiatry, 2018
Schizophrenia is associated with diverse cognitive deficits, including disorders of attention-related oculomotor behavior. At the structural level, schizophrenia is associated with abnormal inhibitory control in the circuit linking cortex and thalamus ...
Yohan J. John, Basilis Zikopoulos, Daniel Bullock, Helen Barbas   +3 more
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Treatment of Cerebral Ischemia Through NMDA Receptors: Metabotropic Signaling and Future Directions

Frontiers in Pharmacology, 2022
Excessive activation of N-methyl-d-aspartic acid (NMDA) receptors after cerebral ischemia is a key cause of ischemic injury. For a long time, it was generally accepted that calcium influx is a necessary condition for ischemic injury mediated by NMDA ...
Yuanyuan Li, Xiaokun Cheng, Xiaokun Cheng, Xiaokun Cheng, Xiaokun Cheng, Xinying Liu, Le Wang, Le Wang, Jing Ha, Jing Ha, Jing Ha, Zibin Gao, Zibin Gao, Zibin Gao, Xiaoliang He, Zhuo Wu, Aibing Chen, Linda L. Jewell, Yongjun Sun, Yongjun Sun, Yongjun Sun   +20 more
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Memory and the NMDA Receptors [PDF]

New England Journal of Medicine, 2009
Ablating mice of Neto1, a component that stabilizes a postsynaptic glutamate receptor, results in a deficit in memory and learning — a deficit ameliorated by administration of a glutamate-receptor stimulant.
Fei, Li, Joe Z, Tsien
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Upregulation of PPAR-gamma activity inhibits cyclooxygenase 2 expression in cortical neurons with N-methyl-d-aspartic acid induced excitatory neurotoxicity

Biotechnology & Biotechnological Equipment, 2019
This study aimed to investigate the effect of upregulated peroxisome proliferator-activated receptor-gamma (PPAR-γ) activity on cyclooxygenase 2 (COX-2) expression and N-methyl-d-aspartic acid (NMDA)-induced excitatory neurotoxicity in primary cultured ...
Qi-Fang Weng, Guo-Bin Chen, Min-Guang Xu, Ru-Tao Long, Han Wang, Xiao-Ying Wang, Chao-Na Jiang, Xi-Nan Yi   +7 more
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Acute Effects of Intravenous Sub-Anesthetic Doses of Ketamine and Intranasal Inhaled Esketamine on Suicidal Ideation: A Systematic Review and Meta-Analysis

Neuropsychiatric Disease and Treatment, 2023
Cheng-Chuan Chen,1,* Na Zhou,2,* Na Hu,1 Jian-Guo Feng,1 Xiao-Bin Wang1 1Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, People’s Republic of China; 2School of Nursing, Southwest ...
Chen CC, Zhou N, Hu N, Feng JG, Wang XB
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Pulsed Radiofrequency Decreases pERK and Affects Intracellular Ca2+ Influx, Cytosolic ATP Level, and Mitochondrial Membrane Potential in the Sensitized Dorsal Root Ganglion Neuron Induced by N-Methyl D-Aspartate [Corrigendum]

Journal of Pain Research, 2023
Laksono RM, Kalim H, Rohman MS, Widodo N, Ahmad MR, Halim W. J Pain Res. 2023;16:1697–1711. The authors have advised affiliation 1 on page 1697 is incorrect.
Laksono RM, Kalim H, Rohman MS, Widodo N, Ahmad MR, Halim W   +5 more
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N-Methyl-D-aspartate (NMDA) and cannabinoid CB2 receptors form functional complexes in cells of the central nervous system: insights into the therapeutic potential of neuronal and microglial NMDA receptors

Alzheimer’s Research & Therapy, 2021
Background The cannabinoid CB2 receptor (CB2R), which is a target to afford neuroprotection, and N-methyl-D-aspartate (NMDA) ionotropic glutamate receptors, which are key in mediating excitatory neurotransmission, are expressed in both neurons and glia ...
Rafael Rivas-Santisteban, Alejandro Lillo, Jaume Lillo, Joan-Biel Rebassa, Joan S. Contestí, Carlos A. Saura, Rafael Franco, Gemma Navarro   +7 more
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