Results 11 to 20 of about 154,177 (308)

Ofatumumab Therapy and Long-Term Seizure Outcomes of Patients With Relapsing Anti-NMDA Receptor Encephalitis. [PDF]

Ann Clin Transl Neurol
ABSTRACT Objective There is a lack of studies on seizure outcomes associated with ofatumumab therapy in patients for relapsing anti‐N‐methyl‐D‐aspartate (NMDA) receptor encephalitis. We aimed to evaluate long‐term seizure outcomes of ofatumumab therapy for relapsing anti‐NMDA receptor encephalitis.
Wang J, Li M, Kong P.
europepmc   +2 more sources

Establishment of an adult zebrafish model of retinal neurodegeneration induced by NMDA [PDF]

International Journal of Ophthalmology, 2019
AIM: To establish a model of retinal neurodegeneration induced by N-Methyl-D-aspartic acid (NMDA) in adult zebrafish. METHODS: We compared the effects of three different NMDA delivery methods on retinal neurodegeneration in adult zebrafish: immersion (I.
Zhi-Wen Luo, Han-Tsing Wang, Ning Wang, Wei-Wei Sheng, Ming Jin, Ye Lu, Yi-Jiang Bai, Su-Qi Zou, Yu-Lian Pang, Hong Xu, Xu Zhang   +10 more
doaj   +1 more source

Norrin Protects Retinal Ganglion Cells from Excitotoxic Damage via the Induction of Leukemia Inhibitory Factor

Cells, 2020
Purpose: To investigate whether and how leukemia inhibitory factor (Lif) is involved in mediating the neuroprotective effects of Norrin on retinal ganglion cells (RGC) following excitotoxic damage.
Stefan Kassumeh, Stephanie Leopold, Rudolf Fuchshofer, Carina N. Thomas, Siegfried G. Priglinger, Ernst R. Tamm, Andreas Ohlmann   +6 more
doaj   +1 more source

Studies of NMDA receptor function and stoichiometry with truncated and tandem subunits [PDF]

, 2003
The subunits that compose eukaryotic glutamate ion channel receptors have three transmembrane domains (TMs) and terminate with intracellular tails that are important for controlling channel expression and localization.
Schorge, S., David Colquhoun, Colquhoun, D., Stephanie Schorge   +3 more
core   +1 more source

Potentiation of glycine-gated NR1/NR3A NMDA receptors relieves Ca2+-dependent outward rectification [PDF]

, 2010
Glycine has diverse functions within the mammalian central nervous system. It inhibits postsynaptic neurons via strychnine-sensitive glycine receptors (GlyRs) and enhances neuronal excitation through co-activation of N-methyl-D-aspartate (NMDA) receptors.
Betz, H., Christian Madry, Geiger, Jörg R. P., Bodo Laube, Betz, Heinrich, Jörg Geiger, Laube, B., Madry, Christian, Madry, C., Geiger, J., Laube, Bodo, Heinrich Betz   +11 more
core   +1 more source

The NMDA agonist D-cycloserine facilitates fear memory consolidation in humans [PDF]

, 2009
Animal research suggests that the consolidation of fear and extinction memories depends on N-methyl D-aspartate (NMDA)- type glutamate receptors.
Dolan, RJ, Holt, Beatrice, Holt, B., Kalisch, R, Büchel, C, Martino, Benedetto de, Büchel, Christian, Dolan, R. ; https://orcid.org/, Kalisch, R., Büchel, C., Holt, B, Klöppel, Stefan, Dolan, R.J., Petrovic, P,, Petrovic, P., Petrovic, Predrag, De Martino, B., Klöppel, S., Dolan, Raymond J., De, Martino B, Kalisch, Raffael, Klöppel, S   +21 more
core   +1 more source

Visual Attention Decits in Schizophrenia Can Arise From Inhibitory Dysfunction in Thalamus or Cortex

Computational Psychiatry, 2018
Schizophrenia is associated with diverse cognitive deficits, including disorders of attention-related oculomotor behavior. At the structural level, schizophrenia is associated with abnormal inhibitory control in the circuit linking cortex and thalamus ...
Yohan J. John, Basilis Zikopoulos, Daniel Bullock, Helen Barbas   +3 more
doaj   +1 more source

Treatment of Cerebral Ischemia Through NMDA Receptors: Metabotropic Signaling and Future Directions

Frontiers in Pharmacology, 2022
Excessive activation of N-methyl-d-aspartic acid (NMDA) receptors after cerebral ischemia is a key cause of ischemic injury. For a long time, it was generally accepted that calcium influx is a necessary condition for ischemic injury mediated by NMDA ...
Yuanyuan Li, Xiaokun Cheng, Xiaokun Cheng, Xiaokun Cheng, Xiaokun Cheng, Xinying Liu, Le Wang, Le Wang, Jing Ha, Jing Ha, Jing Ha, Zibin Gao, Zibin Gao, Zibin Gao, Xiaoliang He, Zhuo Wu, Aibing Chen, Linda L. Jewell, Yongjun Sun, Yongjun Sun, Yongjun Sun   +20 more
doaj   +1 more source

Upregulation of PPAR-gamma activity inhibits cyclooxygenase 2 expression in cortical neurons with N-methyl-d-aspartic acid induced excitatory neurotoxicity

Biotechnology & Biotechnological Equipment, 2019
This study aimed to investigate the effect of upregulated peroxisome proliferator-activated receptor-gamma (PPAR-γ) activity on cyclooxygenase 2 (COX-2) expression and N-methyl-d-aspartic acid (NMDA)-induced excitatory neurotoxicity in primary cultured ...
Qi-Fang Weng, Guo-Bin Chen, Min-Guang Xu, Ru-Tao Long, Han Wang, Xiao-Ying Wang, Chao-Na Jiang, Xi-Nan Yi   +7 more
doaj   +1 more source

Acute Effects of Intravenous Sub-Anesthetic Doses of Ketamine and Intranasal Inhaled Esketamine on Suicidal Ideation: A Systematic Review and Meta-Analysis

Neuropsychiatric Disease and Treatment, 2023
Cheng-Chuan Chen,1,* Na Zhou,2,* Na Hu,1 Jian-Guo Feng,1 Xiao-Bin Wang1 1Department of Anesthesiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, People’s Republic of China; 2School of Nursing, Southwest ...
Chen CC, Zhou N, Hu N, Feng JG, Wang XB
doaj