Results 211 to 220 of about 110,343 (264)

NMDA retseptorsüsteemid NMDA retseptorsüsteemid

2009
N-metüül-D-aspartaadi (NMDA) retseptorite kaudu toimuv kaltsiumiioonide sissevool närvirakkudesse on vajalik närvisüsteemis toimuvateks füsioloogilisteks protsessideks. Selle süsteemi üleaktivatsiooni tingimustes suureneb markantselt postsünaptilistes neuronites intratsellullarse Ca2+ hulk ning see on neuronite degeneratsiooni üks võtmeprotsesse. Selle
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?????????????????? NMDA-???????????????????? ??????????????????: ?????????????????????????? ?????????????????????? ?? ???????????????????? ?? ????????????????????????

2013
?? ???????????? ?????????????????? ?????????????????????????? ?? ?????????????????????????????????? ???????????????????????????? ???????????????????????????????????????????????????????????????????? NMDA-???????????????????? ???????????????????? ?? ???????????????????? ?? ???????????????????????????????? ?????????????????????????? (???????????????????? ?
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NMDA Receptor Antagonists and Glycine Site NMDA Antagonists

Current Medical Research and Opinion, 2002
Extracellular concentrations of excitatory amino acids increase substantially within cerebral tissue beds exposed to ischaemic conditions. This leads to excessive stimulation of N-methyl-D-aspartate (NMDA) receptors, a major cerebral excitatory neurotransmitter receptor that likely plays a critical role in the propagation of ischaemic injury in neurons.
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A Fast Synaptic Potential Mediated by NMDA and Non-NMDA Receptors

Journal of Neurophysiology, 1997
Wolszon, Laura R., Alberto E. Pereda, and Donald S. Faber. A fast synaptic potential mediated by NMDA and non-NMDA receptors. J. Neurophysiol. 78: 2693–2706, 1997. Excitatory synaptic transmission in the CNS often is mediated by two kinetically distinct glutamate receptor subtypes that frequently are colocalized, the N-methyl-d-aspartate (NMDA) and ...
L R, Wolszon, A E, Pereda, D S, Faber
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STUDIES OF NMDA- AND NON-NMDA-MEDIATED NEUROTOXICITY IN CULTURED NEURONS

Neurochemistry International, 1996
The neurotoxic effects of various glutamate agonists were studied using whole fetal rat brain cultures. The results showed that L-glutamate (L-glu) and N-methyl-D-aspartate (NMDA) were the most potent agonists for inducing neurotoxicity, producing significant toxicity at 0.10 and 0.01 mM concentrations, respectively.
D L, Deupree, X W, Tang, M, Yarom, E, Dickman, R D, Kirch, J V, Schloss, J Y, Wu   +6 more
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Subtypes of NMDA receptors

General Pharmacology: The Vascular System, 1993
1. Beginning with electrophysiological evidence for two populations of receptors for N-methyl-D-aspartate (NMDA) which did or did not respond to the agonist quinolinic acid, evidence has grown for such subdivision. 2. Data from binding studies is consistent with differences between three NMDA receptors in the striatum, thalamus and cerebellum with ...
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Astrocytic NMDA Receptors

Biochemistry (Moscow)
Astrocytic NMDA receptors (NMDARs) are heterotetramers, whose expression and properties are largely determined by their subunit composition. Astrocytic NMDARs are characterized by a low sensitivity to magnesium ions and low calcium conductivity. Their activation plays an important role in the regulation of various intracellular processes, such as gene ...
Artem M, Kosenkov, Sergei A, Maiorov, Sergei G, Gaidin   +2 more
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The NMDA receptor complex

Fundamental & Clinical Pharmacology, 1993
Summary— The synaptic responses elicited by glutamate and aspartate in the CNS are mediated by distinct groups of receptors which include the ionotropic NMDA receptor. The NMDA receptor is activated by high‐strength synaptic input and produces relatively sustained depolarization which can lead to repetitive burst firing.
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Increased NMDA affinity of the H780Q mutant of the NMDA receptor

Inorganica Chimica Acta, 1996
A point mutation within the coding sequence of the primary subunit of the N-methyl-d-aspartatge (NMDA) subtypr of glutamate receptor (glutamine substitution for histidine at position 780) exhibits a higher affinity for NMDA than the wild type receptor (EC50 5 versus 27 μM).
Andrew T. Gray, Dmitri J. Leonoudakis, Philip E. Bickler, C. Spencer Yost   +3 more
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The NMDA Receptor1

NeuroRehabilitation, 1991
Traumatic brain injury can produce neurochemical alterations in the brain that are of sufficient magnitude to cause neurological and cognitive deficits. These alterations are associated with a period of excessive neurotransmitter-receptor stimulation involving the N-Methyl-D-aspartate (NMDA) glutamate receptor, as well as other receptors. This abnormal
Lyeth, Bruce G., Jenkins, Larry W., Hayes, Ronald L.   +2 more
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