Results 211 to 220 of about 110,732 (265)

?????????????????? NMDA-???????????????????? ??????????????????: ?????????????????????????? ?????????????????????? ?? ???????????????????? ?? ????????????????????????

2013
?? ???????????? ?????????????????? ?????????????????????????? ?? ?????????????????????????????????? ???????????????????????????? ???????????????????????????????????????????????????????????????????? NMDA-???????????????????? ???????????????????? ?? ???????????????????? ?? ???????????????????????????????? ?????????????????????????? (???????????????????? ?
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Ethanol and the NMDA receptor

Alcohol, 1990
The actions of glutamate, the major excitatory amino acid in the CNS, are mediated by three receptor subtypes: kainate, quisqualate and N-methyl-D-aspartate (NMDA) receptors. Ethanol, in vitro, is a potent and selective inhibitor of the actions of agonists at the NMDA receptor.
P L, Hoffman, C S, Rabe, K A, Grant, P, Valverius, M, Hudspith, B, Tabakoff   +5 more
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NMDA Receptor Antagonists and Glycine Site NMDA Antagonists

Current Medical Research and Opinion, 2002
Extracellular concentrations of excitatory amino acids increase substantially within cerebral tissue beds exposed to ischaemic conditions. This leads to excessive stimulation of N-methyl-D-aspartate (NMDA) receptors, a major cerebral excitatory neurotransmitter receptor that likely plays a critical role in the propagation of ischaemic injury in neurons.
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Trafficking of NMDA Receptors

Annual Review of Pharmacology and Toxicology, 2003
The NMDA receptor (NMDAR) plays a central role in the function of excitatory synapses. Recent studies have provided interesting insights into several aspects of the trafficking of this receptor in neurons. The NMDAR is not a static resident of the synapse. Rather, the number and composition of synaptic NMDARs can be modulated by several factors.
Robert J, Wenthold, Kate, Prybylowski, Steve, Standley, Nathalie, Sans, Ronald S, Petralia   +4 more
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NMDA receptors and schizophrenia

Current Opinion in Pharmacology, 2007
The pathophysiology of schizophrenia is poorly understood but is likely to involve alterations in excitatory glutamatergic signaling molecules in several areas of the brain. Clinical and experimental evidence has shown that expression of the N-methyl-D-aspartate (NMDA) receptor and intracellular NMDA receptor-interacting proteins of the glutaminergic ...
Lars V, Kristiansen, Ibone, Huerta, Monica, Beneyto, James H, Meador-Woodruff   +3 more
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Astrocytic NMDA Receptors

Biochemistry (Moscow)
Astrocytic NMDA receptors (NMDARs) are heterotetramers, whose expression and properties are largely determined by their subunit composition. Astrocytic NMDARs are characterized by a low sensitivity to magnesium ions and low calcium conductivity. Their activation plays an important role in the regulation of various intracellular processes, such as gene ...
Artem M, Kosenkov, Sergei A, Maiorov, Sergei G, Gaidin   +2 more
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A Fast Synaptic Potential Mediated by NMDA and Non-NMDA Receptors

Journal of Neurophysiology, 1997
Wolszon, Laura R., Alberto E. Pereda, and Donald S. Faber. A fast synaptic potential mediated by NMDA and non-NMDA receptors. J. Neurophysiol. 78: 2693–2706, 1997. Excitatory synaptic transmission in the CNS often is mediated by two kinetically distinct glutamate receptor subtypes that frequently are colocalized, the N-methyl-d-aspartate (NMDA) and ...
L R, Wolszon, A E, Pereda, D S, Faber
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STUDIES OF NMDA- AND NON-NMDA-MEDIATED NEUROTOXICITY IN CULTURED NEURONS

Neurochemistry International, 1996
The neurotoxic effects of various glutamate agonists were studied using whole fetal rat brain cultures. The results showed that L-glutamate (L-glu) and N-methyl-D-aspartate (NMDA) were the most potent agonists for inducing neurotoxicity, producing significant toxicity at 0.10 and 0.01 mM concentrations, respectively.
D L, Deupree, X W, Tang, M, Yarom, E, Dickman, R D, Kirch, J V, Schloss, J Y, Wu   +6 more
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Subtypes of NMDA receptors

General Pharmacology: The Vascular System, 1993
1. Beginning with electrophysiological evidence for two populations of receptors for N-methyl-D-aspartate (NMDA) which did or did not respond to the agonist quinolinic acid, evidence has grown for such subdivision. 2. Data from binding studies is consistent with differences between three NMDA receptors in the striatum, thalamus and cerebellum with ...
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Increased NMDA affinity of the H780Q mutant of the NMDA receptor

Inorganica Chimica Acta, 1996
A point mutation within the coding sequence of the primary subunit of the N-methyl-d-aspartatge (NMDA) subtypr of glutamate receptor (glutamine substitution for histidine at position 780) exhibits a higher affinity for NMDA than the wild type receptor (EC50 5 versus 27 μM).
Andrew T. Gray, Dmitri J. Leonoudakis, Philip E. Bickler, C. Spencer Yost   +3 more
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