Results 221 to 230 of about 154,177 (308)

Posttranslational Modifications of p62/SQSTM1 in Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Schematic illustration of p62 as a posttranslational modifications (PTMs)‐programmed integrator in homeostasis, pathogenesis, and therapeutic targeting. (Left) Homeostasis: In physiological states, p62, through various PTMs such as phosphorylation, ubiquitination, and acetylation, coordinates essential cellular functions.
Weikai Wang, Xin Jiang, Runing Qiu, Chandra Sugiarto Wijaya, Miaoqin Chen, Jin Wang, Liyuan Zhu, Hongchuan Jin, Lifeng Feng   +8 more
wiley   +1 more source

Task‐Related Neurotransmitter Dynamics in the Visual Cortex: A Proof‐of‐Concept Time‐Resolved fMRS Study Using a Sustained Vigilance Paradigm

NMR in Biomedicine, Volume 39, Issue 10, October 2026.
Using time‐resolved fMRS at 3T, we observed task‐evoked increases in Glx within the human primary visual cortex during sustained vigilance paradigm. Glx dynamics showed an exploratory association with behavioral performance. These findings suggest that time‐resolved fMRS may capture excitatory neurochemical changes related to sustained visual ...
I‐Ting Lee, Shang‐Hua N. Lin, Rong‐Rung Kuo, Ching‐Po Lin, Li‐Hung Chang   +4 more
wiley   +1 more source

Clinical Images: Tumor necrosis factor inhibitor–associated demyelination in a case of neuro‐Behçet disease

ACR Open Rheumatology, Volume 8, Issue 10, October 2026.
Eloise Norman, Gabor Major
wiley   +1 more source

Implementation of the In Vitro Seizure Liability Assay (iLAseizure) in Drug Discovery and Development: Mechanism of Action Case Studies

Pharmacology Research &Perspectives, Volume 14, Issue 5, October 2026.
ABSTRACT Central nervous system (CNS) liabilities remain a significant cause of attrition during small molecule drug development. We previously developed the in vitro seizure liability assay (iLAseizure), a new approach methodology (NAM) comprising a human induced pluripotent stem cell neuron microelectrode array (MEA) assay coupled with a panel of ...
Kimberly Rockley, Ruth Roberts, Hannah Jennings, Karen Jones, Magali‐Anne Maizières, Michael Morton   +5 more
wiley   +1 more source

Genetic Rescue of Disrupted Synaptic Protein Interaction Network Dynamics Following SYNGAP1 Reactivation. [PDF]

Mol Cell Proteomics
Stamenkovic V, Harsh F, Kniffen B, Rumbaugh G, Smith SEP.   +4 more
europepmc   +1 more source

Mitochondrial Calcium Uniporter protects hippocampal CA2 neurons from NMDA-induced excitotoxic injury. [PDF]

Mol Med
Skweres A, Beręsewicz-Haller M, Basheer O, Nalepa M, Owczarek A, Szymanowski J, Kawalec M, Gruszczyńska-Biegała J, Zabłocka B, Węgrzynowicz M.   +9 more
europepmc   +1 more source

Evaluation of the therapeutic efficacy of the dextromethorphan-bupropion combination and its mediating pathways in a mouse model of major depressive disorder. [PDF]

Front Pharmacol
Buran Kavuran İ, Önalan E, Türk Zİ, Eröksüz H.   +3 more
europepmc   +1 more source

Anti-N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis Presenting as Acute Psychosis and Seizures in a Patient With Multiple Sclerosis: A Diagnostic Challenge. [PDF]

Cureus
Izadian Bidgoli A, Buryk Y, Pina A.
europepmc   +1 more source