Results 271 to 280 of about 240,251 (364)

Enhancement of hippocampal interneuron excitability by NMDA receptor positive allosteric modulation

The Journal of Physiology, EarlyView.
Abstract figure legend EU1622‐240 is a positive allosteric modulator of NMDA receptors. Administration of EU1622‐240 increases both EPSPs and IPSPs in CA1 pyramidal cells. The increased EPSP was attributable to direct potentiation of GluN2B expressed by pyramidal cells.
Hao Xing, Tue G. Banke, Lu Zhang, Kuai Yu, Chad R. Camp, Russell G. Fritzemeier, Nicholas S. Akins, Srinu Paladugu, Paul J. Arcoria, Brian R. Brady, Olga Prikhodko, Matthew J. Kennedy, Dennis C. Liotta, Hongjie Yuan, Stephen F. Traynelis   +14 more
wiley   +1 more source

Exploring the Therapeutic Potential of Ketamine and Psilocybin in Comparison to Current Treatment Regimens for Treatment-Resistant Depression, Mood Disorders, and Post-traumatic Stress Disorder in the Pediatric Population: A Narrative Review. [PDF]

Cureus
Hughes B, Mirza S, Ponamala M, Sagaser J, Paredes R, Hematillake N, Tailor C, Khan R, Pemminati S.   +8 more
europepmc   +1 more source

Molecular and functional diversity of the NMDA receptor channel.

, 1994
Kenji Sakimura, Masayoshi Mishina
openalex   +1 more source

Field observations: Photoperiod response and yield of hemp at various latitudes throughout New Mexico

Agrosystems, Geosciences &Environment, Volume 8, Issue 4, December 2025.
Abstract There has been a rapid increase in research to understand the genetic and agroclimatic interactions of hemp (Cannabis sativa L.) relative to its economic viability. Initial field trials at New Mexico State University were conducted in 2021 and 2022 at three sites across the state for high‐cannabidiol (CBD), grain, and fiber hemp types.
Hanah T. Rheay, Rebecca Creamer, Dawn VanLeeuwen, Catherine E. Brewer   +3 more
wiley   +1 more source

Functional deletion of α7 nicotinic acetylcholine receptor impairs Ca²⁺-dependent glutamatergic synaptic transmission by affecting both presynaptic and postsynaptic protein expression and function. [PDF]

Front Physiol
Cannata B, Sposito L, Albini M, Aceto G, Puliatti G, Lazzarino G, Ripoli C, Tropea MR, Puzzo D, Piacentini R, Grassi C.   +10 more
europepmc   +1 more source

Drug‐Related Engrams and Their Role in the Persistence and Recurrence of Drug‐Related Behaviors

Hippocampus, Volume 35, Issue 6, November 2025.
ABSTRACT Memory is a cornerstone of human behavior, and addiction offers a compelling model of its persistence and plasticity. The scope of engram research has rapidly expanded to include addiction‐related phenomena. Addiction‐related memories, like strong aversive memories, are often highly resistant to extinction and can continue to drive relapse ...
M. Cutler, A. Thati, S. L. Grella
wiley   +1 more source

β‐Adrenergic Receptor Activation Modulates the Induction of Complex Spike‐Dependent LTP by Regulating Multiple Forms of Heterosynaptic Plasticity

Hippocampus, Volume 35, Issue 6, November 2025.
ABSTRACT Norepinephrine, acting through β‐adrenergic receptors (β‐ARs), has a key role in hippocampus‐dependent forms of learning. Although β‐AR activation also facilitates the induction of Hebbian LTP, recent findings indicate that a non‐Hebbian form of synaptic plasticity, known as behavioral timescale synaptic plasticity (BTSP), underlies ...
Thomas J. O'Dell
wiley   +1 more source

Targeting Histone H3K9 Methyltransferase G9a as a Potential Therapeutic Strategy for Neuropsychiatric Disorders

Medicinal Research Reviews, Volume 45, Issue 6, Page 1547-1563, November 2025.
ABSTRACT Neuropsychiatric disorders present a multifaceted challenge, characterized by cognitive, social, and motor impairments with manifold underlying mechanisms. Recent attention has turned to epigenetic mechanisms, particularly histone lysine methyltransferases (HKMTs), such as G9a, in understanding fundamental pathogenesis.
Malak Hajar, Tobias Werner, Mihajlo Gajic, Holger Stark, Bassem Sadek   +4 more
wiley   +1 more source

Molecular and cellular mechanisms underlying gyrate atrophy: Why is the retina primarily affected?

Acta Ophthalmologica, Volume 103, Issue 7, Page e436-e455, November 2025.
Abstract Gyrate atrophy of the choroid and retina (GACR; OMIM #258870) is a rare early‐onset autosomal recessive disorder, caused by bi‐allelic pathogenic variants in the gene coding for ornithine aminotransferase (OAT) resulting in hyperornithinaemia.
Mark J. N. Buijs, Berith M. Balfoort, Marion M. Brands, Anneloor L. M. A. ten Asbroek, Camiel J. F. Boon, Roselie M. H. Diederen, Corrie Timmer, Margreet A. E. M. Wagenmakers, Hans R. Waterham, Ronald J. A. Wanders, Riekelt H. Houtkooper, Clara D. van Karnebeek, Arthur A. Bergen   +12 more
wiley   +1 more source