Results 301 to 310 of about 217,671 (368)

Presence of NMDA receptor in neuroblastoma x glioma NG108-15 cell

, 1992
Seitaro Ohkuma, Masashi Katsura, Da‐Zhi Chen, Kinya Kuriyama   +3 more
openalex   +1 more source

The effect of M‐current activation on controller gain and obstructive sleep apnoea severity: a randomised controlled trial using flupirtine

The Journal of Physiology, EarlyView.
Abstract figure legend Investigating the effect of flupirtine, a KCNQ channel opener, on ventilatory control instability (i.e. loop gain) and obstructive sleep apnoea (OSA) severity. Left panel: high loop gain has been shown to contribute to airway collapse in patients with OSA.
Luke D. J. Thomson, Shane A. Landry, Andre Arellano, Jinny Collet, Stuart Huddle, Denise M. O'Driscoll, Dwayne L. Mann, Caroline Beatty, Simon A. Joosten, Garun S. Hamilton, Phillip J. Berger, Ian Cooke, Bradley A. Edwards   +12 more
wiley   +1 more source

SIRT4 Protects Retina Against Excitotoxic Injury by Promoting OPA1-Mediated Müller Glial Cell Mitochondrial Fusion and GLAST Expression. [PDF]

Invest Ophthalmol Vis Sci
Ying Q, Luo H, Xie Z, Huang Y, Hu H, Jin M, Xu K, Pang Y, Song Y, Zhang X.   +9 more
europepmc   +1 more source

Molecular and functional diversity of the NMDA receptor channel.

, 1994
Kenji Sakimura, Masayoshi Mishina
openalex   +1 more source

Memantine Exacerbates Trimethyltin‐Induced Neurodegeneration and Delays Cognitive Impairment Recovery

Neuropsychopharmacology Reports, Volume 45, Issue 2, June 2025.
Trimethyltin (TMT) induces transient neuronal loss and cognitive impairments, serving as a model for transient brain damage. This study investigated the effects of early memantine (MEM) treatment on TMT‐induced brain injury. Memantine worsened TMT‐induced cognitive impairment and neuronal degeneration in the hippocampus, suggesting that early MEM ...
Yusuke Onaka, Taro Yamaguchi, Takumu Yamasaki, Koki Morishige, Masanori Yoneyama   +4 more
wiley   +1 more source

The human intelligence evolved from proximal cis‐regulatory saltations

Quantitative Biology, Volume 13, Issue 2, June 2025.
Abstract The divergence rate between the alignable genomes of humans and chimpanzees is as little as 1.23%. Their phenotypical difference was hypothesized to be accounted for by gene regulation. We construct the cis‐regulatory element frequency (CREF) matrix to represent the proximal regulatory sequences for each species.
Xiaojie Li, Jianhui Shi, Lei M. Li
wiley   +1 more source

Correction for Patel et al., Aspirin binds to PPARα to stimulate hippocampal plasticity and protect memory. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

NMDA Receptor-Mediated Ca²⁺ Flux Attenuated by the NMDA Receptor/TRPM4 Interface Inhibitor Brophenexin. [PDF]

Pharmacol Res Perspect
Casby J, Gansemer BM, Thayer SA.
europepmc   +1 more source

Astrocytes Mediate Psychostimulant‐Induced Alterations of Spike‐Timing Dependent Synaptic Plasticity

Glia, Volume 73, Issue 5, Page 1051-1067, May 2025.
Main Points Cocaine and amphetamine stimulates astrocytes and downregulates the GLT‐1. The dysfunction in GLT‐1 modify EPSP kinetics and modulate STDP, switching LTP to LTD in psychostimulant‐treated mice. These effects were restored by upregulation of GLT‐1.
Samuel Alberquilla, Carmen Nanclares, Sara Expósito, Grace Gall, Paulo Kofuji, Alfonso Araque, Eduardo D. Martín, Rosario Moratalla   +7 more
wiley   +1 more source

The diverse effects of ketamine, jack-of-all-trades: a narrative review. [PDF]

Br J Anaesth
Richards ND, Howell SJ, Bellamy MC, Beck J.   +3 more
europepmc   +1 more source