Medicinal Research Reviews, Volume 45, Issue 3, Page 985-1015, May 2025.ABSTRACT This review provides a comprehensive overview of the role of G9a/EHMT2, focusing on its structure and exploring the impact of its pharmacological and/or gene inhibition in various neurological diseases. In addition, we delve into the advancements in the design and synthesis of G9a/EHMT2 inhibitors, which hold promise not only as a treatment ...
Aina Bellver‐Sanchis +10 more
wiley +1 more source
DYRK1A Up-Regulation Specifically Impairs a Presynaptic Form of Long-Term Potentiation. [PDF]
Life (Basel)Lepagnol-Bestel AM +6 more
europepmc +1 more source
Rare but relevant: Nitrous oxide and peripheral neurotoxicity, what do we know?
Addiction, Volume 120, Issue 5, Page 1046-1050, May 2025.Abstract Nitrous oxide (N2O), used medically as an anaesthetic, has gained popularity as a recreational drug, with rising prevalence particularly among young adults. While its reinforcing and addictive potential remains debated, N2O is proven to be neurotoxic, especially with prolonged, heavy use, which is often unexpected for users.
Tibor M. Brunt +2 more
wiley +1 more source
The prevalence of chronic traumatic encephalopathy in a historical epilepsy post‐mortem collection
Brain Pathology, Volume 35, Issue 3, May 2025.In an archival epilepsy post‐mortem collection from last century, chronic traumatic encephalopathy identified in 15.7% was associated with traumatic brain injury. Alzheimer's disease neuropathology change was increased in late‐onset epilepsy but in 8% of cases with severe epilepsy there was no tau pathology found. Abstract Previous post‐mortem epilepsy
Maritchka Ryniejska +4 more
wiley +1 more source
Hypoxia tolerance determine differential gelsenicine-induced neurotoxicity between pig and mouse. [PDF]
BMC MedHuang CY +10 more
europepmc +1 more source
Brain Pathology, Volume 35, Issue 3, May 2025.This study analyzes four public transcriptome datasets from AD patients and age‐matched controls, revealing that the transcriptomic profile in female controls closely resembles that of AD patients. We identified a co‐expressed gene module associated with AD, sex, and aging, enriched with immune‐related functions.
Huiying Wen +14 more
wiley +1 more source
Developmental Medicine &Child Neurology, Volume 67, Issue 5, Page 591-599, May 2025.Hypoxic‐ischemic encephalopathy (HIE) is a neurologic condition that is caused by insufficient oxygen and blood flow to a newborn infant’s brain. Although therapeutic hypothermia can reduce the degree of brain injury in some infants with HIE, many infants with HIE will have significant lifelong disabilities despite receiving this treatment.
Natalie H. Chan +5 more
wiley +1 more source
Potentiation of NMDA Receptors by AT1 Angiotensin Receptor Activation in Layer V Pyramidal Neurons of the Rat Prefrontal Cortex. [PDF]
Int J Mol SciHanuska A +11 more
europepmc +1 more source
Org24598, a Selective Glycine Transporter 1 (GlyT1) Inhibitor, Reverses Object Recognition and Spatial Memory Impairments Following Binge-like Ethanol Exposure in Rats. [PDF]
MoleculesFilarowska-Jurko J +9 more
europepmc +1 more source
Transcriptomic Dysregulation in Animal Models of Attention-Deficit Hyperactivity Disorder and Nicotine Dependence Suggests Shared Neural Mechanisms. [PDF]
Brain BehavVan Horn S, Driscoll H, Toufexis DJ.
europepmc +1 more source