Results 321 to 330 of about 240,251 (364)
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STUDIES OF NMDA- AND NON-NMDA-MEDIATED NEUROTOXICITY IN CULTURED NEURONS
Neurochemistry International, 1996The neurotoxic effects of various glutamate agonists were studied using whole fetal rat brain cultures. The results showed that L-glutamate (L-glu) and N-methyl-D-aspartate (NMDA) were the most potent agonists for inducing neurotoxicity, producing significant toxicity at 0.10 and 0.01 mM concentrations, respectively.
John V. Schloss +6 more
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General Pharmacology: The Vascular System, 1993
1. Beginning with electrophysiological evidence for two populations of receptors for N-methyl-D-aspartate (NMDA) which did or did not respond to the agonist quinolinic acid, evidence has grown for such subdivision. 2. Data from binding studies is consistent with differences between three NMDA receptors in the striatum, thalamus and cerebellum with ...
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1. Beginning with electrophysiological evidence for two populations of receptors for N-methyl-D-aspartate (NMDA) which did or did not respond to the agonist quinolinic acid, evidence has grown for such subdivision. 2. Data from binding studies is consistent with differences between three NMDA receptors in the striatum, thalamus and cerebellum with ...
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Fundamental & Clinical Pharmacology, 1993
Summary—The synaptic responses elicited by glutamate and aspartate in the CNS are mediated by distinct groups of receptors which include the ionotropic NMDA receptor. The NMDA receptor is activated by high‐strength synaptic input and produces relatively sustained depolarization which can lead to repetitive burst firing.
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Summary—The synaptic responses elicited by glutamate and aspartate in the CNS are mediated by distinct groups of receptors which include the ionotropic NMDA receptor. The NMDA receptor is activated by high‐strength synaptic input and produces relatively sustained depolarization which can lead to repetitive burst firing.
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Altered NMDA Sensitivity and Learning Following Chronic Developmental NMDA Antagonism
Physiology & Behavior, 1997We have previously shown that chronic developmental administration of N-methyl-D-aspartate (NMDA) antagonists reduces synaptic development; however, on withdrawal from NMDA antagonism, there is a rebound period during which synaptogenesis exceeds control levels.
Janelle C. LeBoutillier +3 more
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Single-channel evidence for glycine and NMDA requirement in NMDA receptor activation
Brain Research, 1996N-Methyl-D-aspartate (NMDA) receptor dose-response relationships that are based on macroscopic currents suggest that NMDA and a different agonist molecule, glycine, must together activate the channel. Since single-channel recordings have a much higher resolution than whole-cell currents, they provide a highly sensitive test for the absolute requirement
Barry S. Pallotta, Margarita C. Currá
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NMDA Receptors as Voltage Sensors
2017The membrane potential is an essential parameter of a living cell. However, measurements of the membrane potential using conventional techniques are associated with a number of artifacts. Cell-attached recordings of the currents through NMDA receptor channels enable noninvasive measurements of the neuronal membrane potential.
Roustem Khazipov +2 more
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Journal of Neurochemistry, 1994
Abstract: The object of this investigation was to determine whether glutamate uptake affects the apparent potency of the competitive antagonists dl‐2‐amino‐5‐phosphonovalerate and CGS‐19755 in blocking NMDA receptor‐mediated neurotoxicity. In astrocyte‐rich rat cortical cultures we observed that dl‐2‐amino‐5‐phosphonovalerate and CGS‐19755 were 24 and ...
Elias Aizenman +4 more
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Abstract: The object of this investigation was to determine whether glutamate uptake affects the apparent potency of the competitive antagonists dl‐2‐amino‐5‐phosphonovalerate and CGS‐19755 in blocking NMDA receptor‐mediated neurotoxicity. In astrocyte‐rich rat cortical cultures we observed that dl‐2‐amino‐5‐phosphonovalerate and CGS‐19755 were 24 and ...
Elias Aizenman +4 more
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Chapter 13 Modulation of NMDA receptors
1998Publisher Summary This chapter describes how phosphorylation reactions might regulate the behavior of the N-methyl-D-aspartate (NMDA) channels in central neurons. The ubiquity of protein phosphorylation and dephosphorylation necessitates a recognition that while NMDA receptors may be directly phosphorylated, there are likely a variety of other ...
Beverley A. Orser +7 more
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Adenosine and NMDA Receptors Modulate Neuroprotection-Induced NMDA Preconditioning in Mice
Journal of Molecular Neuroscience, 2019The severity score of quinolinic acid (QA)-induced seizures was investigated after N-methyl-D-aspartate (NMDA) preconditioning associated with adenosine receptors. Also, the levels of adenosine A1 and A2A receptors and subunits of NMDA receptors in the hippocampi of mice were determined to define components of the resistance mechanism.
Adriana B. Ghislandi +7 more
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Peripheral NMDA and non-NMDA receptors contribute to nociception: an electrophysiological study
Brain Research Bulletin, 2000The present study investigated the effects of peripheral administration of N-methy-D-aspartate (NMDA) and non-NMDA receptor antagonists on C-fiber evoked responses of the spinal dorsal horn neurons in the spinalized rats. When DL-2-amino-5-phosphonovaleric acid (AP5) (10 mM, 1 mM, 0.1 mM, 20 microl) or 6, 7-dinitroquinoxaline-2, 3-dione (DNQX) (1 mM, 0.
Cong-Ying Wang +2 more
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