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Down-regulation of NMDA receptor activity by NMDA
Neuroscience Letters, 1993Rat cerebellar granule cells were cultured in a medium containing 25 mM KCl. The presence of NMDA during culture caused strong down-regulation of 45Ca uptake through the NMDA receptor channel. The process affected neither the viability nor the protein content of the cells. The developmental program of NMDA receptor activity was resumed after removal of
Michael Schramm, Yael Oster
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The Neuroscientist, 2007
The amino acid L-Glutamate acts as the most ubiquitous mediator of excitatory synaptic transmission in the central nervous system. Glutamatergic transmission is central for diverse brain functions, being particularly important for learning, memory, and cognition. In brain pathology, excessive release of glutamate triggers excitotoxic neural cell death
Verkhratsky, Alexei, Kirchhoff, Frank
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The amino acid L-Glutamate acts as the most ubiquitous mediator of excitatory synaptic transmission in the central nervous system. Glutamatergic transmission is central for diverse brain functions, being particularly important for learning, memory, and cognition. In brain pathology, excessive release of glutamate triggers excitotoxic neural cell death
Verkhratsky, Alexei, Kirchhoff, Frank
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Implication of non-NMDA and NMDA receptors in cochlear ischemia
NeuroReport, 1992We have investigated the hypothesis that the acute ischemic swelling of the radial dendrites connected to the inner hair cells (IHCs) is mediated by glutamatergic receptors. In control cochleas, after 20 min ischemia all the dendrites were dramatically swollen.
Rémy Pujol +2 more
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Retinogeniculate transmission by NMDA and non-NMDA receptors in the cat
Brain Research, 1991The contributions of N-methyl-D-aspartate (NMDA) and non-NMDA excitatory amino acid (EAA) receptors to retinogeniculate transmission were investigated in the cat. The EAA antagonists 2-amino-5-phosphonovaleric acid (APV) and kynurenic acid (KYN) were used to block the NMDA receptors and all EAA receptors, respectively.
Klaus Funke, Ulf T. Eysel, T. Fitzgibbon
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Journal of Neurochemistry, 1994
Abstract:Transient forebrain or global ischemia in rats induces selective and delayed damage of hippocampal CA1 neurons. In a previous sludy, we have shown that expression of GIuR2, the kainate/a‐amino‐3‐hydroxy‐5‐ methyl‐4‐isoxazolepropionic acid (AMPA) receptor subunit that governs Ca′ permeability, is preferentially reduced in CA1 at a time point ...
PELLEGRINI-GIAMPIETRO, DOMENICO EDOARDO +2 more
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Abstract:Transient forebrain or global ischemia in rats induces selective and delayed damage of hippocampal CA1 neurons. In a previous sludy, we have shown that expression of GIuR2, the kainate/a‐amino‐3‐hydroxy‐5‐ methyl‐4‐isoxazolepropionic acid (AMPA) receptor subunit that governs Ca′ permeability, is preferentially reduced in CA1 at a time point ...
PELLEGRINI-GIAMPIETRO, DOMENICO EDOARDO +2 more
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Alcohol, 1990
The actions of glutamate, the major excitatory amino acid in the CNS, are mediated by three receptor subtypes: kainate, quisqualate and N-methyl-D-aspartate (NMDA) receptors. Ethanol, in vitro, is a potent and selective inhibitor of the actions of agonists at the NMDA receptor.
Kathleen A. Grant +5 more
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The actions of glutamate, the major excitatory amino acid in the CNS, are mediated by three receptor subtypes: kainate, quisqualate and N-methyl-D-aspartate (NMDA) receptors. Ethanol, in vitro, is a potent and selective inhibitor of the actions of agonists at the NMDA receptor.
Kathleen A. Grant +5 more
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Current Opinion in Neurobiology, 2004
Dynamic modulation of the number of postsynaptic glutamate receptors is considered one of the main mechanisms for altering the strength of excitatory synapses in the central nervous system (CNS). However, until recently N-methyl-d-aspartate (NMDA) receptors were considered relatively stable once in the plasma membrane, especially in comparison with ...
Yue-Qiao Huang +2 more
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Dynamic modulation of the number of postsynaptic glutamate receptors is considered one of the main mechanisms for altering the strength of excitatory synapses in the central nervous system (CNS). However, until recently N-methyl-d-aspartate (NMDA) receptors were considered relatively stable once in the plasma membrane, especially in comparison with ...
Yue-Qiao Huang +2 more
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Synapse, 1991
AbstractIdentified crayfish visual interneurons respond to illumination with a compound EPSP of up to 40 mV. L‐gultamate, quisqualate, and kainate mimic the depolarizing action of the natural transmitter. In reduced Mg2+, N‐methyl‐D‐aspartate (NMDA) elicits a depolarization with a reversal potential (Erev) = −60 mV. Erev is independent of extracellular
Cindy Pfeiffer-Linn, Raymon M. Glantz
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AbstractIdentified crayfish visual interneurons respond to illumination with a compound EPSP of up to 40 mV. L‐gultamate, quisqualate, and kainate mimic the depolarizing action of the natural transmitter. In reduced Mg2+, N‐methyl‐D‐aspartate (NMDA) elicits a depolarization with a reversal potential (Erev) = −60 mV. Erev is independent of extracellular
Cindy Pfeiffer-Linn, Raymon M. Glantz
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Mechanisms of NMDA receptor regulation
Current Opinion in Neurobiology, 2023N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated ion channels widely expressed in the central nervous system that play key role in brain development and plasticity. On the downside, NMDAR dysfunction, be it hyperactivity or hypofunction, is harmful to neuronal function and has emerged as a common theme in various neuropsychiatric disorders ...
Mony, Laetitia, Paoletti, Pierre
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NMDA receptors and schizophrenia
Current Opinion in Pharmacology, 2007The pathophysiology of schizophrenia is poorly understood but is likely to involve alterations in excitatory glutamatergic signaling molecules in several areas of the brain. Clinical and experimental evidence has shown that expression of the N-methyl-D-aspartate (NMDA) receptor and intracellular NMDA receptor-interacting proteins of the glutaminergic ...
James H. Meador-Woodruff +3 more
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