Results 351 to 360 of about 217,671 (368)

Altered NMDA Sensitivity and Learning Following Chronic Developmental NMDA Antagonism

Physiology & Behavior, 1997
We have previously shown that chronic developmental administration of N-methyl-D-aspartate (NMDA) antagonists reduces synaptic development; however, on withdrawal from NMDA antagonism, there is a rebound period during which synaptogenesis exceeds control levels.
Janelle C. LeBoutillier, William J. Brooks, Andrew C.W. Weeks, Ted L. Petit   +3 more
openaire   +3 more sources

NMDA Receptors as Voltage Sensors

2017
The membrane potential is an essential parameter of a living cell. However, measurements of the membrane potential using conventional techniques are associated with a number of artifacts. Cell-attached recordings of the currents through NMDA receptor channels enable noninvasive measurements of the neuronal membrane potential.
Roustem Khazipov, Roustem Khazipov, Roustem Khazipov   +2 more
openaire   +5 more sources

Single-channel evidence for glycine and NMDA requirement in NMDA receptor activation

Brain Research, 1996
N-Methyl-D-aspartate (NMDA) receptor dose-response relationships that are based on macroscopic currents suggest that NMDA and a different agonist molecule, glycine, must together activate the channel. Since single-channel recordings have a much higher resolution than whole-cell currents, they provide a highly sensitive test for the absolute requirement
Barry S. Pallotta, Margarita C. Currá
openaire   +3 more sources

Peripheral NMDA and non-NMDA receptors contribute to nociception: an electrophysiological study

Brain Research Bulletin, 2000
The present study investigated the effects of peripheral administration of N-methy-D-aspartate (NMDA) and non-NMDA receptor antagonists on C-fiber evoked responses of the spinal dorsal horn neurons in the spinalized rats. When DL-2-amino-5-phosphonovaleric acid (AP5) (10 mM, 1 mM, 0.1 mM, 20 microl) or 6, 7-dinitroquinoxaline-2, 3-dione (DNQX) (1 mM, 0.
Cong-Ying Wang, Ying-Wei Wang, Zhi-Qi Zhao   +2 more
openaire   +3 more sources

Chapter 13 Modulation of NMDA receptors

1998
Publisher Summary This chapter describes how phosphorylation reactions might regulate the behavior of the N-methyl-D-aspartate (NMDA) channels in central neurons. The ubiquity of protein phosphorylation and dephosphorylation necessitates a recognition that while NMDA receptors may be directly phosphorylated, there are likely a variety of other ...
Beverley A. Orser, Beverley A. Orser, Janet MacDonald, XG Xiong, XG Xiong, Wei-Yang Lu, Wei-Yang Lu, Ramin Raouf   +7 more
openaire   +3 more sources

Adenosine and NMDA Receptors Modulate Neuroprotection-Induced NMDA Preconditioning in Mice

Journal of Molecular Neuroscience, 2019
The severity score of quinolinic acid (QA)-induced seizures was investigated after N-methyl-D-aspartate (NMDA) preconditioning associated with adenosine receptors. Also, the levels of adenosine A1 and A2A receptors and subunits of NMDA receptors in the hippocampi of mice were determined to define components of the resistance mechanism.
Adriana B. Ghislandi, Michelle L. Garcez, Gabriela M. Zambon, Leandra C. Constantino, Douglas N. Matos, Bruna B. Pescador, Carla I. Tasca, Carina R. Boeck   +7 more
openaire   +3 more sources

NMDA RECEPTORS IN ALCOHOLISM

2003
Abstract Alcohol dependence (“alcoholism”) is diagnosed based in part on the development of physiological adaptations to alcohol (ethanol) including tolerance and dependence, and loss of control over alcohol intake. It is believed that alcohol is initially ingested for its reinforcing effects (positive or negative), and that adaptive changes in the ...
openaire   +3 more sources

Comparison of the Potency of Competitive NMDA Antagonists Against the Neurotoxicity of Glutamate and NMDA

Journal of Neurochemistry, 1994
Abstract: The object of this investigation was to determine whether glutamate uptake affects the apparent potency of the competitive antagonists dl‐2‐amino‐5‐phosphonovalerate and CGS‐19755 in blocking NMDA receptor‐mediated neurotoxicity. In astrocyte‐rich rat cortical cultures we observed that dl‐2‐amino‐5‐phosphonovalerate and CGS‐19755 were 24 and ...
Elias Aizenman, Karen A. Hartnett, Rachel C. Blitzblau, Paul A. Rosenberg, Elizabeth K. Speliotes   +4 more
openaire   +2 more sources

Astrocytic NMDA Receptors

Biochemistry (Moscow)
Astrocytic NMDA receptors (NMDARs) are heterotetramers, whose expression and properties are largely determined by their subunit composition. Astrocytic NMDARs are characterized by a low sensitivity to magnesium ions and low calcium conductivity. Their activation plays an important role in the regulation of various intracellular processes, such as gene ...
Artem M, Kosenkov, Sergei A, Maiorov, Sergei G, Gaidin   +2 more
openaire   +2 more sources

NMDA AND NON-NMDA RECEPTOR MEDIATED SYNAPSES IN CORTEX

Clinical Neuropharmacology, 1992
David C. West, Alex M. Thomson
openaire   +3 more sources