Results 111 to 120 of about 107,984 (270)

Tau is required for the function of extrasynaptic NMDA receptors

open access: yesScientific Reports, 2019
Tau is a microtubule-associated neuronal protein found mainly in axons. However, increasing evidence indicates that it is also present in dendrites, where it serves as an essential mediator of synaptic NMDA (N-methyl-D-aspartate) receptor-dependent ...
Noemí Pallas-Bazarra   +4 more
doaj   +1 more source

Oral morphine used to control intensive pain in a dog (canis familiaris) with tonsil carcinoma, and metastasis in medial retropharyngeal lymph node

open access: yesVeterinary Record Case Reports, EarlyView.
Abstract An 11‐year‐old, female West Highland white terrier presenting cough, emesis, diarrhoea and hyporexia refractory to symptomatic treatment was subjected to endoscopy showing increased palatine tonsil region. Biopsy findings revealed a carcinoma. Computed tomography also showed an increased right medial retropharyngeal lymph node dorsally related
Jiuli R. S. de Salles   +2 more
wiley   +1 more source

Chronic pain management in a dairy cow with deep digital sepsis

open access: yesVeterinary Record Case Reports, EarlyView.
Abstract This case report describes a cow with a penetrating foreign body in the sole horn of its medial claw of the right forelimb, leading to sequestration and necrosis of the pedal bone and subsequent chronic pain. The surgical interventions, multimodal pain management and development of the gait pattern over more than 6 weeks are described. The cow
Jasmin Laschinger, Johann Kofler
wiley   +1 more source

The Influence of Childhood Trauma on the Real‐World Effectiveness of Ketamine in Adults With Treatment‐Resistant Depression

open access: yesActa Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Childhood trauma is a well‐established risk factor for major depressive disorder (MDD) and is often associated with attenuated response to conventional antidepressant therapies. Ketamine has emerged as an effective treatment for treatment‐resistant depression (TRD), but the impact of childhood trauma on its effectiveness remains ...
Danica E. Johnson   +4 more
wiley   +1 more source

Treatment of Early‐Onset Specified and Unspecified Bipolar Disorders: A Systematic Review and Strategies for Identifying and Managing a Thermally Dysregulated Subtype in Children

open access: yesActa Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Bipolar disorder (BD), characterized by extreme mood shifts between mania and depression, can manifest in childhood, and pose treatment challenges. Treatment for full‐criteria BD I or II in children has been partially described in the literature, but major uncertainties exist regarding non‐classic presentations, which were ...
Demitri F. Papolos   +2 more
wiley   +1 more source

Cortical ribbon sign: Initial sign of Creutzfeldt–Jakob disease

open access: yes
Journal of General and Family Medicine, EarlyView.
Shiori Nakamichi   +4 more
wiley   +1 more source

Systematic Multi‐Trait Study of Genetic Correlation and Causality Relationships Between General Medical Conditions and Mental Disorders

open access: yesActa Psychiatrica Scandinavica, EarlyView.
ABSTRACT Introduction Increasing evidence has highlighted bidirectional associations between mental disorders and general medical conditions, with underlying causes ranging from lifestyle habits and side effects from medications to genetic contributions. Novel methods now provide a way to estimate the shared genetic underpinnings and the possibility of
Ron Nudel   +2 more
wiley   +1 more source

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