Results 91 to 100 of about 93,956 (144)

Microglia shape presynaptic properties at developing glutamatergic synapses [PDF]

, 2019
Deficient neuron-microglia signaling during brain development is associated with abnormal synaptic maturation. However, the precise impact of deficient microglia function on synaptic maturation and the mechanisms involved remain poorly defined.
Arnoux, Bollinger, Cantaut-Belarif, Constantine-Paton, Conti, De Biase, Dobrunz, Doorn, Dumas, Durand, Durand, Gasparini, Gosselin, Grabert, Hellwig, Hessler, Hoshiko, Hsia, Isaac, Khazipov, Korber, Kullmann, Lam, Lavin, Limatola, Lowery, Maggi, Milior, Miyamoto, Mosser, Nimmerjahn, Pagani, Paolicelli, Paolicelli, Parkhurst, Pascual, Pfeiffer, Piccinin, Ragozzino, Renger, Reshef, Reshef, Ricci-Tersenghi, Sallert, Santello, Schafer, Schecter, Sellner, Semple, Singh, Stevens, Tian, Tremblay, Tremblay, Voronin, Wake, Wasling, Weinhard, Winkler, Wolf, Yoon, Zhan   +61 more
core   +1 more source

In vivo evidence for NMDA receptor mediated excitotoxicity in a murine genetic model of Huntington Disease [PDF]

, 2008
N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant NR2
Joe Tsien, Mary Heng, Peter Detloff, Phillip Wang, Roger Albin   +4 more
core   +1 more source

NMDA Receptor Antagonists: Emerging Insights into Molecular Mechanisms and Clinical Applications in Neurological Disorders

Pharmaceuticals
Neurodegenerative disorders (NDs) include a range of chronic conditions characterized by progressive neuronal loss, leading to cognitive, motor, and behavioral impairments.
Ayodeji Olatunde Egunlusi, Jacques Joubert   +1 more
doaj   +1 more source

Tau is required for the function of extrasynaptic NMDA receptors

Scientific Reports, 2019
Tau is a microtubule-associated neuronal protein found mainly in axons. However, increasing evidence indicates that it is also present in dendrites, where it serves as an essential mediator of synaptic NMDA (N-methyl-D-aspartate) receptor-dependent ...
Noemí Pallas-Bazarra, Jonathan Draffin, Raquel Cuadros, José Antonio Esteban, Jesús Avila   +4 more
doaj   +1 more source

The Clinical Significance of Abnormal Electroencephalography (EEG) Patterns in Patients with Neuropsychiatric Disorders Due to Anti-NMDA Receptor Encephalitis: A Comparative Study

Diagnostics
Background: Anti-NMDA receptor encephalitis is an autoimmune disease characterized by severe neuropsychiatric disturbances, often misdiagnosed as a primary psychiatric disorder.
Alvaro Moreno-Avellán, Arely Juarez-Jaramillo, Maria del Carmen Fernandez Gonzalez-Aragon, Gerardo Quiñones-Pesqueira, Luz Maria Pineda-Centeno, Mariana Espinola-Nadurille, Victoria Martinez-Angeles, Francisco Martinez-Carrillo, Veronica Rivas-Alonso, Daniel San-Juan, Jose Flores-Rivera, Jesus Ramirez-Bermudez   +11 more
doaj   +1 more source

Synaptic NMDA receptors mediate hypoxic excitotoxic death [PDF]

, 2012
Excessive NMDA receptor activation and excitotoxicity underlies pathology in many neuropsychiatric and neurological disorders, including hypoxia/ischemia.
Wroge, Christine M, Hogins, Joshua, Eisenman, Larry, Mennerick, Steven   +3 more
core   +1 more source

NMDA receptor blockade attenuates Japanese encephalitis virus infection-induced microglia activation

Journal of Neuroinflammation
Neurodegeneration and neuroinflammation are key components in the pathogenesis of Japanese Encephalitis caused by Japanese Encephalitis Virus (JEV) infection.
Cheng-Yi Chang, Chih-Cheng Wu, Chung-Yuh Tzeng, Jian-Ri Li, Yu-Fang Chen, Wen-Ying Chen, Yu-Hsiang Kuan, Su-Lan Liao, Chun-Jung Chen   +8 more
doaj   +1 more source

Slow in Motion but Smart in Learning and Memory: Behavioral Changes in Adult NR3A Knockout Mice [PDF]

, 2011
The expression of NMDA receptor subunit NR3A is high in the neonatal brain but low in adults. However, its functional role in the adult brain is obscure.
Ling Wei, Mingke Song, Osama Mohamad, Shan Ping Yu   +3 more
core   +1 more source

NMDA Receptors’ Structural Asymmetry [PDF]

Microscopy and Microanalysis, 2019
Farzad, Jalali-Yazdi, Eric, Gouaux
openaire   +2 more sources

Potassium channel activators protect the N-methyl-D-aspartate-induced cerebral vascular dilation after combined hypoxia and ischemia in piglets [PDF]

, 1998
Background and Purpose-Cerebral arteriolar dilation to N-methyl-D-aspartate (NMDA) is a neuronally mediated multistep process that is sensitive to cerebral hypoxia and ischemia (H/I).
Bari, Ferenc, Domoki, Ferenc, Veltkamp, R.   +2 more
core