Results 71 to 80 of about 114,424 (204)
, 2008 N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant NR2
Joe Tsien +4 more
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NMDA receptor pharmacology: Perspectives from molecular biology
, 2001 The NMDA receptor is an important target for drug development, with agents from many different classes acting on this receptor. While the severe side effects associated with complete NMDA receptor blockade have limited clinical usefulness of most ...
Guttmann, Rodney P. (author) +1 more
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PLoS ONE, 2015 Partial agonists at the NMDA receptor co-agonist binding site may have potential therapeutic efficacy in a number of cognitive and neurological conditions. The entorhinal cortex is a key brain area in spatial memory and cognitive processing.
Alex M Lench +2 more
doaj +1 more source
NMDA receptor feedback mechanism.
, 2019 Summary of CSD dynamics of our model. Initiation due to NMDA receptor with propagation caused by the combination of interstitial glutamate and potassium diffusion. Neuronal swelling causes prolonged activation of NMDA receptors.
Yoichiro Mori (8067518) +2 more
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Modulation of NMDA Receptor Subunits Expression by Concanavalin A
, 2018 The processes of N-methyl-D-aspartate (NMDA) receptor subunits expression were examined in cortical neurons and rat brain in order to investigate how the concanavalin A (Con A) modulates neuronal cells.
오세관, 유지연, 안정혁
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Frontiers in Neurology, 2019 Anti-NMDA receptor encephalitis is a rare and often therapy-responsive autoimmune disease that usually affects young adults and causes neuropsychiatric symptoms.
Franz Felix Konen +7 more
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NMDA Receptor Antagonists for Treatment of Depression
, 2013 Depression is a psychiatric disorder that affects millions of people worldwide. Individuals battling this disorder commonly experience high rates of relapse, persistent residual symptoms, functional impairment, and diminished well-being. Medications have
Zeynep Ates-Alagoz, Adeboye Adejare
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Novel NMDA receptor splice variants
, 2010 Injury to white matter oligodendrocytes is central to several important disorders including cerebral palsy, stroke and multiple sclerosis. Dr. Fern’s group and others have recently shown that NMDA receptors are present on oligodendrocyte processes and ...
António Miguel De Jesus Domingues (7591409)
core
Heliyon, 2018 Neuronal excitotoxicity induced by spreading depolarization occurs during multiple brain diseases. The subsequent extensive releasing of neuronal transmitter glutamate results in over activation of the ionic glutamate receptors and then triggers neuronal
Jia Zhu +5 more
doaj +1 more source
Development of clinically-tolerated NMDA receptor antagonists
, 2020 The clinical potential of most N-methyl-D-Aspartate (NMDA) receptor antagonists as neuroprotectants is hampered by the fact that they block physiological NMDA receptor mediated activity at neuroprotective concentrations.
Lipton, S. A. +2 more
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