Results 131 to 140 of about 197,779 (358)

NMDA Receptor Antagonists: Emerging Insights into Molecular Mechanisms and Clinical Applications in Neurological Disorders

Pharmaceuticals
Neurodegenerative disorders (NDs) include a range of chronic conditions characterized by progressive neuronal loss, leading to cognitive, motor, and behavioral impairments.
Ayodeji Olatunde Egunlusi, Jacques Joubert   +1 more
doaj   +1 more source

NMDA receptor-mediated synaptic excitation selectively inhibited by ethanol in hippocampal slice from adult rat [PDF]

, 1990
Lovinger Dm, Gentry White, FF Weight
openalex   +1 more source

Modulation of the NMDA receptor by polyamines

Life Sciences, 1991
Results of recent biochemical and electrophysiological studies have suggested that a recognition site for polyamines exists as part of the NMDA receptor complex. This site appears to be distinct from previously described binding sites for glutamate, glycine, Mg++,Zn++, and open-channel blockers such as MK-801.
Marc A. Dichter, Carmelo Romano, Keith Williams, Perry B. Molinoff   +3 more
openaire   +3 more sources

The mechanisms in glucose metabolism of aging hippocampus

Ibrain, EarlyView.
Cognitive decline in elders stems from the irreversible loss and functional decline of neurons, with the hippocampus being particularly susceptible to age‐related neuronal deterioration. Glucose acts as the primary fuel for the brain, and a constant provision of glucose to the hippocampus is essential for memory and cognitive functions.
Rui He, Fuxing Zhao, Zhiyu Yang, Tingting Wang, Yaohui Zhang, Jinglan Quan, Gaohong Zhu   +6 more
wiley   +1 more source

Tau is required for the function of extrasynaptic NMDA receptors

Scientific Reports, 2019
Tau is a microtubule-associated neuronal protein found mainly in axons. However, increasing evidence indicates that it is also present in dendrites, where it serves as an essential mediator of synaptic NMDA (N-methyl-D-aspartate) receptor-dependent ...
Noemí Pallas-Bazarra, Jonathan Draffin, Raquel Cuadros, José Antonio Esteban, Jesús Avila   +4 more
doaj   +1 more source

Kindling induces the long-lasting expression of a novel population of NMDA receptors in hippocampal region CA3 [PDF]

, 1994
J.E. Kraus, GC Yeh, DW Bonhaus, J. Victor Nadler, JO McNamara   +4 more
openalex   +1 more source

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

iMetaOmics, EarlyView.
This narrative review uniquely addresses how gut microbiota‐derived metabolites mediate overlapping pathologies of insulin resistance, neuroinflammation, and amyloidogenesis in type 2 diabetes mellitus (T2DM) and Alzheimer's disease (AD), proposing a framework for dual therapeutic targeting.
Guangyi Xu, Yu An, Yage Du, Zhaoming Cao, Jie Zheng, Jingya Wang, Tingyi Li, Xingen Lei, Yanhui Lu   +8 more
wiley   +1 more source

Perinatal Exposure to the Neonicotinoid Thiacloprid Impacts Transcription of Neuroplasticity and Neuroendocrine Markers in Mice but Not in the Zebrafish Model

Journal of Applied Toxicology, EarlyView.
ABSTRACT Neonicotinoids are widely used insecticides in agriculture, aquaculture, pet care, and urban pest control. Initially developed to selectively target the insect cholinergic system, their extensive use has raised concerns about adverse effects on nontarget vertebrates.
Kirthana Kunikullaya U, Zuzanna M. Baran, Pascal Coumailleau, Laetitia Guillot, Harry W. M. Steinbusch, Fatima Smagulova, Thierry D. Charlier   +6 more
wiley   +1 more source

Immunolocalization of NMDA receptors in the central nervous system of weakly electric fish: functional implications for the modulation of a neuronal oscillator [PDF]

, 1994
John E. Spiro, Nils Brose, SF Heinemann, Walter Heiligenberg   +3 more
openalex   +1 more source

Oligodendrocyte Precursor Cells in Demyelination Repair: Mechanisms, Crosstalk, and Therapeutic Frontiers

Medicine Bulletin, EarlyView.
ABSTRACT In multiple sclerosis (MS), demyelination is often accompanied by severe motor and cognitive disability. Remyelination is the process of regenerating new myelin sheath on impaired axons, which is typically carried out by oligodendrocyte precursor cells (OPCs).
Zixin Gao, Mengdi Guo, Kehan Chen, Mei‐Ling Jiang, Lin‐ming Zhang, Lorenzo Di Cesare Mannelli, Cun‐jin Zhang   +6 more
wiley   +1 more source