Results 141 to 150 of about 107,984 (270)

(2R,6R)‐hydroxynorketamine prevents opioid abstinence‐related negative affect and stress‐induced reinstatement in mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Opioid use disorder (OUD) is a pressing public health concern marked by frequent relapse during periods of abstinence, perpetuated by negative affective states. Classical antidepressants or the currently prescribed opioid pharmacotherapies have limited efficacy to reverse the negative affect or prevent relapse ...
Andria Michael, Anna Onisiforou, Polymnia Georgiou, Morfeas Koumas, Chris Powels, Elmar Mammadov, Andrea N. Georgiou, Panos Zanos   +7 more
wiley   +1 more source

Characterization of the Cerebroprotective Efficacy of the Competitive NMDA Receptor Antagonist CGP40116 in a Rat Model of Focal Cerebral Ischemia: An in vivo Magnetic Resonance Imaging Study

, 1993
Dirk Sauer, Peter R. Allegrini, Alexandra Cosenti, A. Pataki, Hugo Amacker, Graham E. Fagg   +5 more
openalex   +1 more source

The Sharpey‐Schafer Prize Lecture. The mechanism of induction of NMDA receptor‐dependent long‐term potentiation in the hippocampus [PDF]

, 1992
Graham L. Collingridge
openalex   +1 more source

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing

British Journal of Pharmacology, EarlyView.
Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti, Valentin Varga, Erda Qorri, Rita Frank, Diana Kata, Krisztián Vinga, Péter Archibald Szarvas, Ákos Menyhárt, Károly Gulya, Ferenc Bari, Eszter Farkas   +10 more
wiley   +1 more source

Phosphodiesterase 3 inhibitors boost bone outgrowth

British Journal of Pharmacology, EarlyView.
Background and Purpose C‐type natriuretic peptide (CNP) stimulates skeletal growth by acting on the growth plates of long bones, and a CNP variant is clinically used for achondroplasia treatment. We previously reported that CNP stimulates the autonomic Ca2+ influx mediated by TRPM7 channels in growth plate chondrocytes to facilitate extracellular ...
Takaaki Kawabe, Atsuhiko Ichimura, Tomoki Yasue, Jianhong Li, Haruki Ishikawa, Ga Eun Kim, Hiroki Nagatomo, Naoto Minamino, Yohei Ueda, Hiromu Ito, Miyuki Nishi, Hiroshi Takeshima   +11 more
wiley   +1 more source

Treatment resistant but not irremediable

Bipolar Disorders, Volume 27, Issue 2, Page 157-160, March 2025.
Gin S. Malhi, Erica Bell, Uyen Le, Philip Boyce, Michael Berk   +4 more
wiley   +1 more source

Neuroprotection for neonatal hypoxic–ischemic encephalopathy: A review of novel therapies evaluated in clinical studies

Developmental Medicine &Child Neurology, Volume 67, Issue 5, Page 591-599, May 2025.
Hypoxic‐ischemic encephalopathy (HIE) is a neurologic condition that is caused by insufficient oxygen and blood flow to a newborn infant’s brain. Although therapeutic hypothermia can reduce the degree of brain injury in some infants with HIE, many infants with HIE will have significant lifelong disabilities despite receiving this treatment.
Natalie H. Chan, Cheryl C. Hawkins, Benjamin V. Rodrigues, Marie‐Coralie Cornet, Fernando F. Gonzalez, Yvonne W. Wu   +5 more
wiley   +1 more source

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, EarlyView.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source

MK-801 blocked the functional NMDA receptors in identified cerebellar neurons

, 1990
Michisuke Yuzaki, Yoshihisa Kudo, Kyoko Akita, Atsushi Miyawaki, Katsuhiko Mikoshiba   +4 more
openalex   +1 more source

Genetic testing in cerebral palsy with clinical and neuroimaging variables

Developmental Medicine &Child Neurology, EarlyView.
Abstract Aim To optimize genetic testing in children with cerebral palsy (CP) by using clinical and magnetic resonance imaging (MRI) variables. Method In this mixed methods study, we surveyed current approaches to genetic testing by Australian clinicians involved in the diagnosis of CP.
Esther M. Tantsis, Shekeeb S. Mohammad, Simon P. Paget, Yisselle I. Virella‐Perez, Velda X. Han, Dianah Hadi, Chaya Goldman, Michelle A. Farrar, Michael Fahey, Russell C. Dale, the GENE‐CP study group, Kristine Alba‐Concepcion, David J Amor, Tajul Arifin Tajudin, Nadia Badawi, Elizabeth Barnes, Bruce Bennetts, Hilla Ben Pazi, Darius Ebrahimi‐Fakhari, Darcy Fehlings, Donna M Ferriero, Jennifer Friedman, Jozef Gecz, Gladys Ho, Sachin Gupta, Rod W Hunt, Kavitha Kothur, Michael Kruer, Manju A Kurian, Maria Kyriagis, Wang Tso Lee, Sarah McIntyre, Aurélie Méneret, Jonathan W Mink, Catherine Morgan, Angela Morrow, Nardo Nardocci, Emanuela Pagliano, Elizabeth E. Palmer, Toni S Pearson, Belén Pérez‐Dueñas, Emmanuel Roze, Michael Shevell, Anna te Velde, Mary‐Clare Waugh, Michèl A Willemsen, Yana A Wilson   +46 more
wiley   +1 more source