Results 141 to 150 of about 22,217 (292)
Movement Disorders, EarlyView.Abstract Background Levodopa‐induced dyskinesia (LID) in Parkinson's disease (PD) is associated with ‘false neurotransmitter’ release of dopamine from serotonin (5‐HT) neurons. NLX‐112 is a first‐in‐class, highly selective 5‐HT1A receptor agonist which counteracts LIDs in experimental PD models.
Per Svenningsson +13 more
wiley +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT This review provides a comprehensive overview of the role of G9a/EHMT2, focusing on its structure and exploring the impact of its pharmacological and/or gene inhibition in various neurological diseases. In addition, we delve into the advancements in the design and synthesis of G9a/EHMT2 inhibitors, which hold promise not only as a treatment ...
Aina Bellver‐Sanchis +10 more
wiley +1 more source
Molecular Ecology, EarlyView., 2023 Abstract Natural variation can provide important insights into the genetic and environmental factors that shape social behaviour and its evolution. The sweat bee, Lasioglossum baleicum, is a socially flexible bee capable of producing both solitary and eusocial nests.
Kennedy S. Omufwoko +5 more
wiley +1 more source
Increased AMPA-sensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus [PDF]
, 1991 D. A. Hosford +7 more
openalex +1 more source
An overview of the non‐procedural treatment options for peripheral neuropathic pain
Muscle &Nerve, EarlyView.Abstract Peripheral neuropathic pain is common in patients with peripheral nerve injury and can significantly impact both their function and quality of life. There is a wide variety of non‐interventional treatment approaches, including pharmacologic therapy, physical/occupational therapy, modalities (therapeutic, mechanical, thermal, etc.), psychology,
Evan R. Zeldin +6 more
wiley +1 more source
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Objectives Acute cerebral ischemia is characterized by several pathological processes evolving during time, which contribute to the final tissue damage. Secondary processes, such as prolonged inflammatory response, impaired mitochondrial function and oxidative stress, are responsible for the progression of brain injury to the peri‐infarct area,
Fioravante Capone +8 more
wiley +1 more source
Interactions between the glycine and glutamate binding sites of the NMDA receptor [PDF]
, 1993 R.A.J. Lester, Gang Tong, CE Jahr
openalex +1 more source
Oral microbiota and central nervous system diseases: A review
Neuroprotection, EarlyView.Potential mechanisms between the oral microbiome and brain. Created with BioGDP.com85. a. Oral microbiota and pathogens invasion through the oral mucosal barrier; b. Immune‐inflammation response within the host caused by bacterial invasion; c. Cytokines traversed through the brain‐blood barrier activate neuroinflammation; d.
Xiaoxuan Zhang +7 more
wiley +1 more source
Basic fibroblast growth factor protects cerebellar neurons in primary culture from NMDA and non‐NMDA receptor mediated neurotoxicity [PDF]
, 1993 M. Teresa Fernández‐Sánchez +1 more
openalex +1 more source